<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Background. Non-coding RNAs (ncRNAs) are key regulatory molecules in cellular processes, and are potential biomarkers in many diseases. Currently, microRNAs and long non-coding RNAs are being pursued as diagnostic and prognostic biomarkers, and as therapeutic tools in cancer, since their expression profiling is able to distinguish different cancer types and classify their sub-types. </p><p>Conclusions. There are numerous studies confirming involvement of ncRNAs in cancer initiation, development and progression, but have only been recently identified as new diagnostic and prognostic tools. This can be beneficial in future medical cancer treatment options, since ncRNAs are natural antisense interactors included in regulation of many genes connected to survival and proliferation. Research is directed in development of useful markers for diagnosis and prognosis in cancer and in developing new RNA-based cancer therapies, of which some are already in clinical trials.</p></abstract>

Background. Non-coding RNAs (ncRNAs) are key regulatory molecules in cellular processes, and are potential biomarkers in many diseases. Currently, microRNAs and long non-coding RNAs are being pursued as diagnostic and prognostic biomarkers, and as therapeutic tools in cancer, since their expression profiling is able to distinguish different cancer types and classify their sub-types. Conclusions. There are numerous studies confirming involvement of ncRNAs in cancer initiation, development and progression, but have only been recently identified as new diagnostic and prognostic tools. This can be beneficial in future medical cancer treatment options, since ncRNAs are natural antisense interactors included in regulation of many genes connected to survival and proliferation. Research is directed in development of useful markers for diagnosis and prognosis in cancer and in developing new RNA-based cancer therapies, of which some are already in clinical trials.

MicroRNAs and long non-coding RNAs: prospects in diagnostics and therapy of cancer

Department of Molecular Genetics, Institute of Pathology, Medical Faculty, University of Ljubljana, Slovenia

Radiology and Oncology

Background. Non-coding RNAs (ncRNAs) are key regulatory molecules in cellular processes, and are potential biomarkers in many diseases. Currently, microRNAs...

MicroRNAs and long non-coding RNAs: prospects in diagnostics and therapy of cancer

Pubblicato online: 08 ott 2013

Pagine: 311 - 318

DOI: https://doi.org/10.2478/raon-2013-0062

Parole chiave
> microRNAs, long non-coding RNAs, diagnosis, therapy, biomarker

This content is open access.

MicroRNAs and long non-coding RNAs: prospects in diagnostics and therapy of cancer

Pubblicato online: 08 ott 2013

Pagine: 311 - 318

DOI: https://doi.org/10.2478/raon-2013-0062

Parole chiave> microRNAs, long non-coding RNAs, diagnosis, therapy, biomarker

This content is open access.

Parole chiave
> microRNAs, long non-coding RNAs, diagnosis, therapy, biomarker