[
1. O’Neill, G.T., Donnelly, K., Marshall, E., Cairns, D., Goldmann, W., Hunter, N. (2003). Characterization of ovine PrP gene promoter activity in N2a neuroblastoma and ovine foetal brain cell lines. J Anim Breed Genet. 120, 114-123. https://doi.org/10.1046/j.1439-0388.2003.00381.x10.1046/j.1439-0388.2003.00381.x
]Search in Google Scholar
[
2. Goldmann, W., Baylis, M., Chihota, C., Stevenson, E., Hunter, N. (2005). Frequencies of PrP gene haplotypes in British sheep f locks and the implications for breeding programmes. J Appl Microbiol. 98, 1294-1302. https://doi.org/10.1111/j.1365-2672.2005.02568.x PMid:1591664310.1111/j.1365-2672.2005.02568.x15916643
]Search in Google Scholar
[
3. Baylis, M., Goldmann, W. (2004). The genetics of scrapie in sheep and goats. Curr Mol Med. 4, 385-396. https://doi.org/10.2174/1566524043360672 PMid:1535486910.2174/156652404336067215354869
]Search in Google Scholar
[
4. Meydan, Özkan, M.M., Yildiz, M.A. (2013). Genetic risk assessment for atypical scrapie in Turkish native sheep breeds. Small Rumin Res. 111, 16-22. https://doi.org/10.1016/j.smallrumres.2012.08.01310.1016/j.smallrumres.2012.08.013
]Search in Google Scholar
[
5. Paludi, D., Thellung, S., Chiovitti, K., Corsaro, A., Villa, V., Russo, C., et al. (2007). Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants. J Neurochem. 103, 2291-2300. https://doi.org/10.1111/j.1471-4159.2007.04934.x PMid:1791929210.1111/j.1471-4159.2007.04934.x17919292
]Search in Google Scholar
[
6. Saunders, G.C., Lantier, I., Cawthraw, S., Berthon, P., Moore, S.J., Arnold, M.E., et al. (2009). Protective effect of the T112 PrP variant in sheep challenged with bovine spongiform encephalopathy. J Gen Virol. 90, 2569-2574. https://doi.org/10.1099/vir.0.012724-0 PMid:1958713310.1099/vir.0.012724-019587133
]Search in Google Scholar
[
7. McIntyre, K.M., Trewby, H., Gubbins, S., Baylis, M. (2010). The impact of sheep breed on the risk of classical scrapie. Epidemiol Infect. 138, 384-392. https://doi.org/10.1017/S0950268809990537 PMid:1967897010.1017/S095026880999053719678970
]Search in Google Scholar
[
8. Drogemuller, C., Leeb, T., Distl, O. (2001). PrP genotype frequencies in German breeding sheep and the potential to breed for resistance to scrapie. Vet Rec. 149, 349-352. https://doi.org/10.1136/vr.149.12.349 PMid:1159438010.1136/vr.149.12.34911594380
]Search in Google Scholar
[
9. Guan, F., Pan, L., Li J., Tang, H., Zhu, C., Shi, G. (2011). Polymorphisms of the prion protein gene and their effects on litter size and risk evaluation for scrapie in Chinese Hu sheep. Virus Genes. 43, 147-152. https://doi.org/10.1007/s11262-011-0609-5 PMid:21556743 PMCid:PMC312464810.1007/s11262-011-0609-5312464821556743
]Search in Google Scholar
[
10. Sartore, S., Rasero, R., Colussi, S., Acutis, P.L., Peletto, S., Soglia, D., et al. (2013). Effect of selection for scrapie resistance on genetic diversity in a rare and locally adapted sheep breed: The case of Sambucana. Livest Sci. 157, 75-80. https://doi.org/10.1016/j.livsci.2013.08.00610.1016/j.livsci.2013.08.006
]Search in Google Scholar
[
11. Brandsma, J.H., Janss, L.L.G., Visscher, A.H. (2005). Association between PrP genotypes and performance traits in an experimental Dutch Texel herd. Livest Prod Sci. 95, 89-94. https://doi.org/10.1016/j.livprodsci.2004.12.01110.1016/j.livprodsci.2004.12.011
]Search in Google Scholar
[
12. Casellas, J., Caja, G., Bach, R., Francino, O., Piedrafita, J. (2007). Association analyses between the prion protein locus and reproductive and lamb weight traits in Ripollesa sheep. J Anim Sci. 85, 592-597. https://doi.org/10.2527/jas.2006-308 PMid:1706042210.2527/jas.2006-30817060422
]Search in Google Scholar
[
13. Woolhouse, M.E., Coen, P., Matthews, L., Foster, J.D., Elsen, J.M., Lewis, R.M., et al. (2001). A centuries-long epidemic of scrapie in British sheep? Trends Microbiol. 9, 67-70. https://doi.org/10.1016/S0966-842X(00)01912-0 PMid:1117324510.1016/S0966-842X(00)01912-0
]Search in Google Scholar
[
14. Gubbins, S., Cook, C.J., Hyder, K., Boulton, K., Davis, C., Thomas, E., et al. (2009). Associations between lamb survival and prion protein genotype: analysis of data for ten sheep breeds in Great Britain. BMC Vet Res. 5, 3. https://doi.org/10.1186/1746-6148-5-3 PMid:19159456 PMCid:PMC263785210.1186/1746-6148-5-3263785219159456
]Search in Google Scholar
[
15. Alfonso, L., Parada, A., Legarra, A., Ugarte, E., Arana, A. (2006). The effects of selective breeding against scrapie susceptibility on the genetic variability of the Latxa Black-Faced sheep breed. Genet Sel Evol. 38, 495-511. https://doi.org/10.1186/1297-9686-38-5-495 PMid:16954042 PMCid:PMC268925910.1186/1297-9686-38-5-495268925916954042
]Search in Google Scholar
[
16. Aguilar-Martínez, C.U., Berruecos-Villalobos, J.M., Espinoza-Gutiérrez, B., Segura-Cor rea, J.C., Valencia-Méndez, J., Roldán-Roldán, A. (2017). Origen, historia y situacion actual de la oveja pelibuey en Mexico. Tropical and Subtropical Agroecosystems 20, 429-439.10.56369/tsaes.2348
]Search in Google Scholar
[
17. OIE (2005) Sampling methods. OIE Manual on Terrestrial Animals. 3-15.
]Search in Google Scholar
[
18. Acin, C., Martin-Burriel, I., Goldmann, W., Lyahyai, J., Monzon, M., Bolea, R., et al. (2004). Prion protein gene polymorphisms in healthy and scrapie-affected Spanish sheep. J Gen Virol. 85, 2103-2110. https://doi.org/10.1099/vir.0.80047-0 PMid:1521819610.1099/vir.0.80047-015218196
]Search in Google Scholar
[
19. Seabury, C.M., Derr, J.N. (2003). Identification of a novel ovine PrP polymorphism and scrapie-resistant genotypes for St. Croix White and a related composite breed. Cytogenet Genome Res. 102, 85-88. https://doi.org/10.1159/000075730 PMid:1497068410.1159/00007573014970684
]Search in Google Scholar
[
20. Heaton, Leymaster, K.A., Freking, B.A., Hawk, D.A., Smith, T.L.P., Keele, J.W., et al. (2003). Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer. Mamm Genome. 14, 765-777. https://doi.org/10.1007/s00335-003-2283-y PMid:1472272610.1007/s00335-003-2283-y14722726
]Search in Google Scholar
[
21. Saunders, G.C., Cawthraw, S., Mountjoy, S.J., Hope, J., Windl, O. (2006). PrP genotypes of atypical scrapie cases in Great Britain. J Gen Virol. 87, 3141-3149. https://doi.org/10.1099/vir.0.81779-0 PMid:1703084610.1099/vir.0.81779-017030846
]Search in Google Scholar
[
22. Vaccari, G., Scavia, G., Sala, M., Cosseddu, G., Chiappini, B., Conte, M., et al. (2009). Protective effect of the AT137RQ and ARQK176 PrP allele against classical scrapie in Sarda breed sheep. Vet Res. 40, 19. https://doi.org/10.1051/vetres/2009002 PMid:19171116 PMCid:PMC269504110.1051/vetres/2009002269504119171116
]Search in Google Scholar
[
23. Hautaniemi, M., Tapiovaara, H., Korpenfelt, S.L., Sihvonen, L. (2012). Genotyping and surveillance for scrapie in Finnish sheep. BMC Vet Res. 8, 122. https://doi.org/10.1186/1746-6148-8-122 PMid:22831168 PMCid:PMC341478310.1186/1746-6148-8-122341478322831168
]Search in Google Scholar
[
24. DeSilva U., Guo X., Kupfer D.M., Fernando S.C., Pillai A.T., Najar F.Z., et al. (2003). Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep. Cytogenet Genome Res. 102, 89-94. https://doi.org/10.1159/000075731 PMid:1497068510.1159/00007573114970685
]Search in Google Scholar
[
25. Lan, Li J., Sun, C., Liu, Y., Zhao, Y., Chi, T., et al. (2014). Allelic variants of PRNP in 16 Chinese local sheep breeds. Arch Virol. 159, 2141-2144. https://doi.org/10.1007/s00705-014-2048-9 PMid:2464333510.1007/s00705-014-2048-924643335
]Search in Google Scholar
[
26. Alvarez, Gutierrez-Gil, B., Uzun, M., Primitivo, F.S., Arranz, J.J. (2011). Genetic variability in the prion protein gene in five indigenous Turkish sheep breeds. Small Rumin Res. 99, 93-98. https://doi.org/10.1016/j.smallrumres.2011.03.04310.1016/j.smallrumres.2011.03.043
]Search in Google Scholar
[
27. Ün, C., Oztabak, K., Ozdemir, N., Akıs, I., Mengi, A. (2008). Genotyping of PrP gene in native Turkish sheep breeds. Small Rumin Res. 74, 260-264. https://doi.org/10.1016/j.smallrumres.2007.06.00210.1016/j.smallrumres.2007.06.002
]Search in Google Scholar
[
28. Teferedegn, E.Y., Yaman, Y., Un, C. (2020). Five novel PRNP gene polymorphisms and their potential effect on Scrapie susceptibility in three native Ethiopian sheep breeds. BMC Vet Res. 16, 122. https://doi.org/10.1186/s12917-020-02336-0 PMid:32349749 PMCid:PMC718946310.1186/s12917-020-02336-0718946332349749
]Search in Google Scholar
[
29. Hunter, N., Moore, L., Hosie, B.D., Dingwall, W.S., Greig, A. (1997). Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland. Vet Rec. 140, 59-63. https://doi.org/10.1136/vr.140.3.59 PMid:902390510.1136/vr.140.3.599023905
]Search in Google Scholar
[
30. Sirakov, I., Peshev, R., Christova, L. (2011). Genetic predisposition of some Bulgarian sheep breeds to the scrapie disease. Virus Genes. 43, 153-159. https://doi.org/10.1007/s11262-011-0615-7 PMid:2153374910.1007/s11262-011-0615-721533749
]Search in Google Scholar
[
31. Meydan Yuceer, B., Degirmenci, R., Ozkan, M.M., Yildiz, M.A. (2012). Prion protein gene polymorphism and genetic risk evaluation for scrapie in all Turkish native sheep breeds. Virus Genes. 45, 169-175. https://doi.org/10.1007/s11262-012-0744-7 PMid:2252864110.1007/s11262-012-0744-722528641
]Search in Google Scholar
[
32. Ianella, P., McManus, C.M., Caetano, A.R., Paiva, S.R. (2012). PRNP haplotype and genotype frequencies in Brazilian sheep: issues for conservation and breeding programs. Res Vet Sci. 93, 219-225. https://doi.org/10.1016/j.rvsc.2011.06.025 PMid:2181644910.1016/j.rvsc.2011.06.02521816449
]Search in Google Scholar
[
33. Lühken, G., Lipsky, S., Peter, C., Erhardt, G. (2008). Prion protein polymorphisms in autochthonous European sheep breeds in respect to scrapie eradication in affected flocks. Small Rumin Res. 75, 43-47. https://doi.org/10.1016/j.smallrumres.2007.07.01010.1016/j.smallrumres.2007.07.010
]Search in Google Scholar
[
34. Slate, J. (2005). Molecular evolution of the sheep prion protein gene. Proc Biol Sci. 272, 2371-2377. https://doi.org/10.1098/rspb.2005.3259 PMid:16243700 PMCid:PMC155997010.1098/rspb.2005.3259155997016243700
]Search in Google Scholar
[
35. Glatt, C.E., DeYoung, J.A., Delgado, S., Service, S.K., Giacomini, K.M., Edwards, R.H., et al. (2001). Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes. Nat Genet. 27, 435-438. https://doi.org/10.1038/86948 PMid:1127952810.1038/8694811279528
]Search in Google Scholar
[
36. SIAP (2021). Sheep, Livestock population, 2012-2021. https://www.gob.mx/cms/uploads/attachment/file/744954/Inventario_2021_ovino.pdf
]Search in Google Scholar
[
37. van Rheede, T., Smolenaars, M.M., Madsen, O., de Jong, W.W. (2003). Molecular evolution of the mammalian prion protein. Mol Biol Evol. 20, 111-121. https://doi.org/10.1093/molbev/msg014 PMid:1251991310.1093/molbev/msg01412519913
]Search in Google Scholar
[
38. Seabury, C.M., Honeycutt, R.L., Rooney, A.P., Halbert, N.D., Derr, J.N. (2004). Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3. Proc Natl Acad Sci U S A. 101, 15142-15147. https://doi.org/10.1073/pnas.0406403101 PMid:15477588 PMCid:PMC52405210.1073/pnas.040640310152405215477588
]Search in Google Scholar
[
39. Tsangaras, K., Kolokotronis, S.O., Ulrich, R.G., Morand, S., Michaux, J., Greenwood, A.D. (2014). Negative purifying selection drives prion and doppel protein evolution. J Mol Evol. 79, 12-20. https://doi.org/10.1007/s00239-014-9632-1 PMid:2503883910.1007/s00239-014-9632-125038839
]Search in Google Scholar
[
40. Sezgin, E., Teferedegn, E.Y., Un, C., Yaman, Y. (2022). Excessive replacement changes drive evolution of global sheep prion protein (PRNP) sequences. Heredity (Edinb). 128, 377-385. https://doi.org/10.1038/s41437-022-00520-6 PMid:3527338310.1038/s41437-022-00520-6907683735273383
]Search in Google Scholar