In vivo efficacy of macrocyclic lactones on goat farms – pour-on vs injectable application

Results of the in vivo faecal egg count reduction test for pour-on eprinomectin and injectable ivermectin on eight goat farms

Farm	Eggs per gram	Pour-on eprinomectin				Injectable ivermectin
		D0	D14	FECR% (95% CI lower and upper bounds)	D0	D14	FECR% (95% CI lower and upper bounds)
1	Mean ± SD	725 ± 861.01	20.00 ± 33.16	96.60 (90, 99)	470.00 ± 2 61.91	30.00 ± 45.82	93.60 (84, 98)
	Min-max	150–3,100	0–100		150–1,000	0–150
2	Mean ± SD	262.50 ± 143.06	125.00 ± 75.00	59.20 (20, 86)	710.00 ± 339.70	130.00 ± 143.52	80.80 (47, 95)
	Min-max	150–500	0–200		150–1,100	0–350
3	Mean ± SD	2,810.00 ± 1,370.36	485.00 ± 597.93	87.10 (77, 93)	2,261.11 ± 2,142.65	288.88 ± 334.81	89.20 (80, 95)
	Min-max	1400–5,300	0–2,000		800–8,150	0–1000
4	Mean ± SD	1,495.00 ± 720.57	100.00 ± 94.86	93.50 (87, 97)	1,325.00 ± 835.16	75.00 ± 93.54	94.70 (87, 98)
	Min-max	250–2,550	0–300		350–2,950	0–250
5	Mean ± SD	970.00 ± 772.39	430.00 ± 448.99	63.50 (36, 81)	545.00 ± 396.51	40.00 ± 76.81	92.30 (85, 96)
	Min-max	150–2,450	0–1,300		150–1,400	0–250
6	Mean ± SD	1,170.00 ± 506.55	430.00 ± 289.13	65.40 (39, 84)	1,155.55 ± 981.33	116.66 ± 97.18	88.00 (73, 94)
	Min-max	250–2,150	0–750		200–3,550	0–350
7	Mean ± SD	1,711.11 ± 1,023.27	694.44 ± 381.84	51.00 (27, 69)	N/A	N/A	N/A
	Min-max	350–3,350	0–1,300
8	Mean ± SD	612.50 ± 544.14	150.00 ± 141.42	69.40 (37, 91)	N/A	N/A	N/A
	Min-max	200–1,950	0–400

The proportions of the gastrointestinal nematode third-stage larvae by species before and after treatment with pour-on eprinomectin and injectable ivermectin for the eight goat farms

Farm	D0 (%)						D14 (%)
					Eprinomectin					Ivermectin
	HC	TEL	TR	OE/CHAB	HC	TEL	TR	OE/CHAB	HC	TEL	TR	OE/CHAB
1	25	55	15	5	100	-	-	-	100	-	-	-
2	42	45	9	4	97	3	-	-	100	-	-	-
3	13	65	8	14	100	-	-	-	100	-	-	-
4	28	53	7	12	100	-	-	-	100	-	-	-
5	68	21	11	-	100	-	-	-	100	-	-	-
6	36	49	12	3	100	-	-	-	100	-	-	-
7	31	59	8	2	95	5	-	-	100	-	-	-
8	56	37	5	2	100	-	-	-	100	-	-	-

The mean numbers of infective third-stage larvae at ivermectin concentrations equal to or higher than the minimum inhibitory concentration of 21_6 ng/mL for the eight goat farms

Farm	Mean number of L3 larvae ± SD at concentrations ≥21.6 ng/mL
1	3.50 ± 4.79
2	24.12 ± 4.42
3	22.75 ± 7.17
4	4.00 ± 1.87
5	5.75 ± 1.47
6	23.00 ± 11.92
7	5.25 ± 1.08
8	8.12 ± 2.84

Interpretation of World Association for the Advancement of Veterinary Parasitology guidelines for faecal egg count reduction test results

Efficacy	Results
Reduced	FECR% < 95% confidence interval and <90%
Doubtful	Either FECR% < 95% or lower limit of the 95% confidence interval or <90%
Normal	FECR% ≥ 95% and lower limit of the 95% confidence interval and ≥ 90%