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Effects of vitamin C and magnesium L-threonate treatment on learning and memory in lead-poisoned mice

Kemajl Bislimi
Kemajl Bislimi
, 
Ilir Mazreku
Ilir Mazreku
, 
Jeton Halili
Jeton Halili
, 
Valbona Aliko
Valbona Aliko
, 
Kushtrim Sinani
Kushtrim Sinani
 e 
Liridon Hoxha
Liridon Hoxha
   | 08 giu 2021
Journal of Veterinary Research's Cover Image
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Pubblicato online: 08 giu 2021
Pagine: 217 - 223
Ricevuto: 27 nov 2020
Accettato: 21 mag 2021
DOI: https://doi.org/10.2478/jvetres-2021-0032
Parole chiave
© 2021 K. Bislimi et al. published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1

Latency or time from the start of the trial to the platform entry. Data were calculated as the mean of blocks of trials (nine trials per day)Vit C– vitamin C; MgT – magnesium L-threonate
Latency or time from the start of the trial to the platform entry. Data were calculated as the mean of blocks of trials (nine trials per day)Vit C– vitamin C; MgT – magnesium L-threonate

Fig. 2

Latency to first entry into the platform zone. Data were calculated as the mean of blocks of trials (nine trials per day) Vit C – vitamin C; MgT – magnesium L-threonate
Latency to first entry into the platform zone. Data were calculated as the mean of blocks of trials (nine trials per day) Vit C – vitamin C; MgT – magnesium L-threonate

Fig. 3

Number of entries in the platform zone (line crossing). Data were calculated as the mean of blocks of trials (nine trials per day) Vit C – vitamin C; MgT – magnesium L-threonate
Number of entries in the platform zone (line crossing). Data were calculated as the mean of blocks of trials (nine trials per day) Vit C – vitamin C; MgT – magnesium L-threonate

Fig. 4

Time in the platform zone. Data were calculated as the mean of blocks of trials (nine trials per day)Vit C – vitamin C; MgT – magnesium L-threonate
Time in the platform zone. Data were calculated as the mean of blocks of trials (nine trials per day)Vit C – vitamin C; MgT – magnesium L-threonate

Catalase activity level (CAT IU/ mg protein) in Swiss albino mouse liver, kidney, pancreas and brain tissue after administration of lead acetate

Group
Control (n = 10) Pb (n = 10) Pb+Vit C (n = 10) Pb+MgT (n = 10) MgT (n = 10)
Organ Liver 222.5 ± 45.61 501.8 ± 70.10* 229.3 ± 54.13 250.2 ± 81.52 204.9 ± 50.02
Pancreas 18.5 ± 8.98 51.2 ± 16.12* 31.3 ± 17.54 26.3 ± 13.22 37.3 ± 16.75
Kidney 97.3 ± 34.56 269.1 ± 55.89** 124.6 ± 43.54 105.3 ± 52.23 130.5 ± 42.54
Brain 3.9 ± 2.86 8.1 ± 3.05* 9.3 ± 3.67* 8.9 ± 3.11* 4.4 ± 2.26

Lead concentration (mg/kg) in the brains of mice treated with different combinations of chemicals

Group
Parameter Control (n = 10) Pb (n = 10) Pb+Vit C (n = 10) Pb+MgT (n = 10) MgT (n = 10)
Pb 0.35 ± 0.001 1.58 ± 0.009* 1.67 ± 0.039* 0.94 ± 0.035* 0.41 ± 0.025

Average values of body weight and food and water intake during the 40 days of treatment

Group Initial average body weight (g) Terminal average body weight (g) Average daily food intake (g) Average daily water intake (mL)
Control 35.24 35.05 6.89 6.21
Pb 33.34 36.97 7.01 6.07
Pb+Vit C 32.24 35.69 6.51 6.11
Pb+MgT 33.52 35.91 6.78 6.15
MgT 34.04 37.12 7.12 6.52

Average organs weights in grams (liver, kidney, pancreas and brain) of mice (Mus musculus Swiss albino) after dissection

Group
Control (n = 10) Pb (n = 10) Pb+Vit C (n = 10) Pb+MgT (n = 10) MgT (n = 10)
Organ Liver 1.02 ± 0.29 0.89 ± 0.08 0.93 ± 0.16 0.92 ± 0.49 1.11 ± 0.26
Pancreas 0.20 ± 0.10 0.17 ± 0.07 0.23 ± 0.07 0.15 ± 0.10 0.17 ± 0.05
Kidney 0.38 ± 0.16 0.50 ± 0.08 0.56 ± 0.12 0.55 ± 0.10 0.43 ± 0.10
Brain 0.35 ± 0.03 0.36 ± 0.05 0.35 ± 0.02 0.36 ± 0.02 0.36 ± 0.04
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Life Sciences, Molecular Biology, Microbiology and Virology, other, Medicine, Veterinary Medicine
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