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Association of oxidative stress biomarkers and clinical mastitis incidence in dairy cows during the periparturient period

George P. Laliotis
George P. Laliotis
, 
Panagiota Koutsouli
Panagiota Koutsouli
, 
Kyriaki Sotirakoglou
Kyriaki Sotirakoglou
, 
Giovanni Savoini
Giovanni Savoini
 e 
Ioannis Politis
Ioannis Politis
   | 12 ago 2020
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Article Category: Short Communication
Pubblicato online: 12 ago 2020
Pagine: 421 - 425
Ricevuto: 19 gen 2020
Accettato: 30 lug 2020
DOI: https://doi.org/10.2478/jvetres-2020-0053
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© 2020 G.P. Laliotis et al. published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1

ROC curve analysis in detecting mastitis incidents based on the determined concentrations of the ROS (1a); SAC (1b); OSi (1c); and α-T levels (1d). Numbers (1, 2, 3) after the name of each biomarker correspond to the examined time points (1 – dry-off; 2 – calving; 3 – 30 d post-partum)
ROC curve analysis in detecting mastitis incidents based on the determined concentrations of the ROS (1a); SAC (1b); OSi (1c); and α-T levels (1d). Numbers (1, 2, 3) after the name of each biomarker correspond to the examined time points (1 – dry-off; 2 – calving; 3 – 30 d post-partum)

Diagnostic performance (receiver operating characteristic curve coordinates) of ROS, SAC, OSi and α-T as predictors of mastitis incidence at dry-off, calving and 30 d post-partum

Biomarker /Sampling point Area (AUC) Under Curve Cut-off (Threshold) Sensitivity Specificity P-value
Dry-off
ROS 0.586a ± 0.060 >50.0 89.5 42.9 ns (0.16)
SAC 0.674ab ± 0.067 ≤450.4 89.5 45.1 **
OSi 0.663b ± 0.057 >0.113 89.5 48.4 **
α-T 0.730b ± 0.048 ≤ 5.2 100 49.5 ***
Calving
ROS 0.869a ± 0.046 >70.2 94.7 71.1 ***
SAC 0.949b ± 0.027 ≤320.4 89.5 88.9 ***
OSi 0.952b ± 0.026 >0.224 89.5 88.9 ***
α -T 0.805a ± 0.045 ≤1.9 94.7 69.2 ***
30 d post-partum
ROS 0.614ab ± 0.064 >46.7 100 26.7 ns (0.075)
SAC 0.592a ± 0.063 ≤467.3 100 26.7 ns (0.14)
OSi 0.636ab ± 0.064 >0.106 94.7 32.2 *
α -T 0.710b ± 0.053 ≤4.5 68.4 75.8 ***

Effect of the health of the udder (healthy or mastitic) on ROS (CarrU), SAC (μmol HClO/ml) and OSi (ROS/SAC) in the blood of dairy cows at dry-off, calving and 30d post-partum. Group A – healthy animals; Group B – mastitic animals. Values are presented as LSM ± SEM

Parameter Group A Group B
Dry-off
ROS 51.87a, 1 ± 0.85 54.85a, 1 ± 1.87
SAC 447.31a, 1 ± 2.52 431.64a, 1 ± 5.52
OSi 0.117a, 1 ± 0.002 0.127a, 1 ± 0.005
Calving
ROS 65.89a, 2 ± 0.86 75.04b, 2 ± 1.87
SAC 347.38a, 2 ± 2.54 312.38b, 2 ± 5.52
OSi 0.191a, 2 ± 0.002 0.240b, 2 ± 0.005
30 d post-partum
ROS 53.46a, 1 ± 0.86 57.07a, 1 ± 1.87
SAC 451.42a, 1 ± 2.54 440.36a, 1 ± 5.52
OSi 0.118a, 1 ± 0.002 0.130a, 1 ± 0.005
eISSN:
2450-8608
Lingua:
Inglese
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Argomenti della rivista:
Life Sciences, Molecular Biology, Microbiology and Virology, other, Medicine, Veterinary Medicine
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