Beta-tubulin |
NSCLC |
High expression of β-tubulin confers worse prognosis |
IHC |
No |
|
BRCA1 |
Breast |
High expression of BRCA1 confers worse prognosis in untreated patients |
IHC |
Yes |
|
NSCLC |
High expression of BRCA1 confers worse prognosis in untreated patients |
qRT-PCR |
No |
|
CA19-9 |
Pancreatic |
Higher preoperative CA19-9 levels are associated with lower resectability, more advanced stage and inferior survival I |
IHC |
No |
|
CAIX |
RCC |
High expression of CAIX is associated with a better prognosis |
IHC |
No |
|
CD44 |
Bladder |
Expression of CD44 is associated with poor prognosis |
qRT-PCR |
No |
|
CEA |
CRC |
Elevated preoperative CEA levels in resectable colorectal cancer is associated with poor prognosis |
IHC |
Yes |
|
c-KIT |
GIST |
GIST patients have a better prognosis if they harbour a mutation in exon 11 of the c-KIT gene |
Pathway detection via FDG-PET |
Yes |
|
ColoPrint |
CRC |
Prognosis for colorectal cancer patients |
Microarray |
Yes |
|
CTC (e.g. CellSearch) |
Melanoma |
Increased number of circulating melanoma cells is associated with poor prognosis |
Circulating tumour cells |
No |
|
CRC |
Colorectal patients with 3 CTC/7.5 ml of peripheral blood were associated with shorter PFS and OS, i.e. poor prognosis |
Circulating tumour cells |
Yes |
|
Breast |
Breast cancer patients with 5 CTC/7.5 mL of peripheral blood are associated with shorter PFS and OS, i.e. poor prognosis 5 CTC/7.5 ml of peripheral blood is associated with poor prognosis |
Circulating tumour cells |
Yes |
|
Prostate |
|
Circulating tumour cells |
Yes |
|
Cyclin D1 |
Bladder |
Expression of Cyclin D1 is associated with low grade, low stage and recurrence |
IHC |
No |
|
Cyclin E |
Bladder |
Expression of Cyclin E is associated with low stage and survival |
IHC |
No |
|
E-Cadherin |
Bladder |
E-Cadherin is associated with poor prognosis |
IHC |
No |
|
EGFR |
Bladder |
Overexpression of EGFR is associated with high grade and high stage |
IHC |
No |
|
NSCLC |
High gene copy number of EGFR in NSCLC patients is associated with poor prognosis |
FISH / SA |
No |
|
|
EGFR mutation in NSCLC patients is associated with better prognosis in untreated patients |
|
|
|
Rectal |
Overexpression of EGFR in rectal cancers is also associated with poor prognosis |
IHC |
No |
|
ER |
Breast |
Patients with ER-positive breast tumours have better survival than patients with hormonal negative tumours |
IHC |
Yes |
|
eXageneBC |
Breast |
Provides prognosis in node-positive or node-negative breast cancer patients |
FISH |
Yes |
|
Her2/neu |
Breast |
Patients with Her2/neu-positive breast tumours are more aggressive and have a worse prognosis compared to Her2/neu-negative tumours |
FISH |
Yes |
|
Bladder |
Overexpression of Her2/neu is associated with high grade, high stage, poor survival and metastasis in bladder cancer |
IHC |
No |
|
GIST |
Overexpression of Her2/neu in advanced gastric cancer patients is associated with poor prognosis |
IHC |
No |
|
Her3 |
Melanoma |
Correlation with increased cell proliferation, tumour progression and reduced survival in melanoma patients |
IHC |
No |
|
ING3 |
Melanoma |
Reduced nuclear expression associated with poor disease- specific survival in melanoma patients |
IHC |
No |
|
ING4 |
Melanoma |
Reduced levels of ING4 in melanoma patients is associated with melanoma thickness, ulceration and poor disease-specific survival and overall survival |
IHC |
No |
|
Ki-67 |
Bladder |
Expression of Ki-67 is associated with progression and recurrence in bladder cancer |
IHC |
No |
|
Breast |
Expression of Ki-67 is associated with proliferation and progression in breast cancer |
IHC |
No |
|
K-ras |
NSCLC |
K-ras mutation is associated with poor prognosis in NSCLC patients |
SA |
Yes |
|
LOH at 18q |
CRC |
Associated with metastasis and poor prognosis in colorectal tumours |
PCR |
No |
|
MammaPrint |
Breast |
A 70-gene prognostic assay used to identify breast cancer cases at the extreme end of the spectrum of disease outcome by identifying patients with good or very poor prognosis |
Microarray |
Yes |
|
Mammostrat |
Breast |
This standard purely prognostic test uses five antibodies with manual slide scoring to divide cases of ER-positive, lymph node negative breast cancer tumours treated with tamoxifen alone into low-, moderate- or high-risk groups |
IHC |
Yes |
|
MMP-2 |
Bladder |
Expression of MMP-2 is associated with poor prognosis in bladder cancer patients |
PCR |
No |
|
MSI status |
CRC |
High frequency MSI colorectal tumours are associated with better prognosis and show improved relapse-free survival |
IHC |
No |
|
NCOA3 |
Melanoma |
Increased levels in melanoma patients correspond to poor relapse-free survival and disease-free survival |
IHC |
No |
|
Oncotype DX |
Breast |
A 21-gene multiplex test used for prognosis to determine 10- year disease recurrence for ER-positive, lymph node negative breast cancers using a continuous variable algorithm and assigning a tripartite recurrence score |
qRT-PCR |
Yes |
|
p21 |
Bladder |
Overexpression of p21 is associated with poor prognosis |
IHC |
No |
|
p53 |
Bladder |
Overexpression of p53 is associated with poor prognosis |
IHC |
No |
|
NSCLC |
High expression of p53 in NSCLC patients confers worse prognosis in untreated patients |
IHC |
No |
|
NSCLC |
p53 mutation in NSCLC patients is associated with worse prognosis |
SA |
No |
|
PR |
Breast |
Patients with PR-positive breast tumours have better survival than patients with hormonal-negative tumours |
IHC |
Yes |
|
Rb |
Bladder |
Overexpression of Rb is associated with poor prognosis |
IHC |
No |
|
RRMI |
NSCLC |
High expression of RRMI in NSCLC patients confers better prognosis in untreated patients |
AQUA |
No |
|
VEGF |
RCC |
Overexpression of VEGF is associated with poor prognosis in clear cell renal carcinoma patients |
IHC |
Yes |