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Fig. 1

Mean (+SD) plasma concentration of norepinephrine (a), β-endorphin (b), and substance P (c) of chronically lame and control dairy cows (N = 25 per MS). * – significant differences compared to MS 0, P < 0.05
Mean (+SD) plasma concentration of norepinephrine (a), β-endorphin (b), and substance P (c) of chronically lame and control dairy cows (N = 25 per MS). * – significant differences compared to MS 0, P < 0.05

Frequency of occurrence of the main foot lesions diagnosed (n = 75; 25 per MS group)

Claw lesions diagnosedMS 1 (%)MS 2 (%)MS 3 (%)Total (%)
Infectious lesion Digital dermatitis003.33.3
Heel erosion2.22.204.4
Interdigital dermatitis1.103.34.4
Non-infectious lesion
Abscess4.41.16.712.2
Double sole4.42.21.17.8
Heel inflammation3.301.14.4
Interdigital callus002.22.2
Overgrowth1.11.102.2
Sole haemorrhage4.412.22.218.9
Ulcer2.23.37.813.3
White line disease1011.15.626.7

Linear mixed effect model of mobility scoring (MS) on norepinephrine, β-endorphin, and substance P plasma concentrations in lame and control dairy cows (N = 25 per MS)

VariableEstimatedStd. Error95% CI
Norepinephrine
MS0655.8324.09607.83 – 703.83
MS1−4.8635.54−75.67 – 65.94
MS265.8534.07−2.03 – 133.72
MS3245.4533.66178.39 – 312.51
β-endorphin
MS046.61.4943.61 – 49.57
MS1−3.82.2−8.20 – 0.59
MS2−5.752.11−9.96 – −1.54
MS3−7.842.09−11.0 – −3.68
Substance P
MS00.250.090.08 – 0.43
MS10.070.13−0.19 – 0.33
MS20.170.12−0.08 – 0.41
MS30.610.120.37 – 0.86
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Life Sciences, Molecular Biology, Microbiology and Virology, other, Medicine, Veterinary Medicine