Overview of Trends in Global Single Cell Research Based on Bibliometric Analysis and LDA Model (2009–2019)
, , , e | 27 nov 2020
INFORMAZIONI SU QUESTO ARTICOLO
Article Category: Research Paper
Pubblicato online: 27 nov 2020
Pagine: 163 - 178
Ricevuto: 08 set 2020
Accettato: 23 ott 2020
DOI: https://doi.org/10.2478/jdis-2021-0008
Parole chiave
© 2021 Tian Jiang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Topics identified by LDA model (K=20).
| Topic | Potential topic | Top20 frequent terms |
|---|---|---|
| 0 | Pathology of brain disease | disease; brain; distribution; relationship; region; pattern; nucleus; age; immunohistochemistry; human brain; cortex; proportion; purpose; hippocampus; cluster; focus; rat; input; neuron; pathology |
| 1 | Mathematical modeling of cell cycle | model; type; control; mechanism; betum; datum; network; cell cycle; complexity; framework; phase; association; simulation; modeling; mouse model; differential expression; account; interplay; prediction; balance |
| 2 | Single cell detection platform | detection; imaging; platform; fluorescence; sensitivity; design; resolution; quantification; device; mass spectrometry; living; sample; measurement; spectrometry; flow; array; magnitude; capability; microfluidic device; chip |
| 3 | Immune response | single-cell level; flow cytometry; infection; biology; single-cell analysis; cytometry; host; memory; emergence; virus; pathogenesis; set; health; inflammation; immune response; immune system; complex; initiation; immunity; site |
| 4 | Signal transduction | response; activity; vivo; activation; pathway; receptor; factor; target; inhibition; phenotype; replication; inhibitor; signaling; overexpression; depletion; miRNA; kinase; zebrafish; oxygen; angiogenesis |
| 5 | Phylogeny on single cell level | sequencing; identification; protocol; diversity; genome; situ hybridization; selection; mutation; life; amplification; analysis; sequence; accuracy; family; transfer; chromosome; classification; genus; total; syndrome |
| 6 | Intracellular calcium modulation | combination; generation; increase; frequency; alpha; action; calcium; injury; channel; layer; heart; stability; difference; modulation; transmission; strength; central nervous system; ion; mu m; mechanism |
| 7 | Single cell gel electrophoresis | treatment; damage; assay; exposure; repair; stress; comparison; apoptosis; cell line; extent; risk; carcinoma; peripheral blood; kidney; glioblastoma; liver; assessment; evaluation; radiation; toxicity |
| 8 | Molecular mechanism of embryonic development | development; mouse; tissue; single-cell resolution; embryo; transcriptome; origin; stage; cell type; mapping; morphogenesis; establishment; skin; immunofluorescence; nervous system; gap; epithelium; molecular mechanism; specification; resource |
| 9 | Cell adhesion | microscopy; surface; interaction; adhesion; spectroscopy; different cell; manipulation; motility; extracellular matrix; binding; chemical; cell surface; force; substrate; bacterium; atomic force; speed; aeruginosa; spectra; spectrum |
| 10 | Isolation and sorting of single cell | single cell; range; isolation; quality; cycle; engineering; antibody; viability; delivery; screening; enrichment; field; high throughput; throughput; amount; droplet; suspension; cell viability; red blood; solution |
| 11 | Cell migration | protein; migration; rate; contrast; loss; context; absence; transition; invasion; cell division; localization; density; organism; division; cell migration; cell size; decrease; fraction; literature; core |
| 12 | Cell-to-cell variability analysis | expression; gene expression; gene; population; transcription; regulation; mRNA; evolution; variability; variation; chromatin; transcription factor; protein expression; correlation; noise; phenotypic; promoter; reporter; cell-to-cell variability; gene regulation |
| 13 | Cancer diagnosis and treatment | cancer; tumor; blood; resistance; therapy; progression; survival; breast cancer; drug; patient; metastasis; death; lung; efficacy; diagnosis; treatment; melanoma; microenvironment; cell death; persistence |
| 14 | Single cell oil | growth; production; yeast; concentration; metabolism; ratio; composition; content; reduction; source; accumulation; plant; degradation; synthesis; abundance; medium; energy; strain; recovery; oil |
| 15 | Stem cell | differentiation; vitro; stem; culture; proliferation; methylation; adult; lineage; regeneration; capacity; progenitor; stem cell; rise; pluripotent stem; fate; bone marrow; maintenance; expansion; marker; embryonic stem |
| 16 | Cellular heterogeneity analysis | analysis; single cell; heterogeneity; level; single-cell; size; cellular heterogeneity; integration; cell population; bulk; volume; chapter; acquisition; individual cell; glioma; drug discovery; cell analysis; tummy; significance; conjunction |
| 17 | Single cell living imaging | addition; potential; membrane; release; stimulation; homeostasis; secretion; situ; change; uptake; transport; cytoplasm; fluorescence microscopy; gamma; iuss; fusion; plasma membrane; phosphorylation; cell biology; real time |
| 18 | Biofilm formation | formation; structure; environment; behavior; light; body; community; form; plasticity; processing; degree; matrix; shape; nature; length; organization; adaptation; space; fixation; assembly |