Hyperglycemia, diabetes, and de novo diabetes in patients hospitalized in intensive care units for COVID-19 in Colombia: Results from a longitudinal cohort study
Categoria dell'articolo: Research Article
Pubblicato online: 31 lug 2025
Pagine: 257 - 264
Ricevuto: 10 giu 2024
Accettato: 05 giu 2025
DOI: https://doi.org/10.2478/jccm-2025-0026
Parole chiave
© 2025 John Jaime Sprockel et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Introduction
Hyperglycemia and diabetes have been identified as risk factors for severe COVID-19 and death, with a high rate of reported de novo diabetes. We evaluated their incidence and relationship with adverse outcomes in critically ill COVID-19 patients.
Methods
Prospective single-center longitudinal cohort study in adults hospitalized in intensive care units for confirmed COVID-19. ROC curves for serum glucose and glycated hemoglobin were plotted in relation to 60-day mortality. A Cox proportional hazards model was used to assess the association of diabetes and de novo diabetes with 60-day mortality.
Results
547 patients were included, with a mean age of 59.8 years; 133 (24.3%) had a history of diabetes, and 67 (12.2%) had de novo diabetes. At 60 days, 317 (57.9%) had died. For mortality, the AUC for glucose at admission was 0.55 (95% CI: 0.48 – 0.62) and 0.51 (95% CI: 0.41 – 0.62) for glycated hemoglobin. In the Cox model, diabetes had an HR of 0.888 (95% CI: 0.695 – 1.135, p: 0.344), history of DM had an HR of 0.881 (95% CI: 0.668 – 1.163, p: 0.371), and de novo diabetes had an HR of 0.963 (95% CI: 0.672 – 1.378, p: 0.835).
Conclusion
There was a high incidence of de novo diabetes in patients hospitalized in intensive care for COVID-19. Neither hyperglycemia, history of diabetes, nor de novo diabetes were associated with the development of complications or 60-day mortality.