A Comparative Analysis of the Effects of Haloperidol and Dexmedetomidine on QTc Interval Prolongation during Delirium Treatment in Intensive Care Units
This work is licensed under the Creative Commons Attribution 4.0 International License.
Krahne D, Heymann A, Spies C. How to monitor delirium in the ICU and why it is important. Clinl Effect Nurs. 2006;9:269–79.KrahneDHeymannASpiesCHow to monitor delirium in the ICU and why it is importantClinl Effect Nurs2006926979Search in Google Scholar
Urden L, Stacy K, Rajabpour NM, et al. Study of Predictors of Delirium Incidence in Hospitalized Patients In Intensive Care Units. Nurs Midwife Commun. 2014;26(18):25–35.UrdenLStacyKRajabpourNMStudy of Predictors of Delirium Incidence in Hospitalized Patients In Intensive Care UnitsNurs Midwife Commun201426182535Search in Google Scholar
Javaherforooshzadeh F, Monajemzadeh SA, Soltanzadeh M, Janatmakan F, Salari A, Saeed H. A Comparative Study of the Amount of Bleeding and Hemodynamic Changes between Dexmedetomidine Infusion and Remifentanil Infusion for Controlled Hypotensive Anesthesia in Lumbar Discopathy Surgery: A Double-Blind, Randomized, Clinical Trial. Anesth Pain Med. 2018;8(2):e66959.JavaherforooshzadehFMonajemzadehSASoltanzadehMJanatmakanFSalariASaeedHA Comparative Study of the Amount of Bleeding and Hemodynamic Changes between Dexmedetomidine Infusion and Remifentanil Infusion for Controlled Hypotensive Anesthesia in Lumbar Discopathy Surgery: A Double-Blind, Randomized, Clinical TrialAnesth Pain Med201882e66959Search in Google Scholar
Al Huraizi AR, Al-Maqbali JS, Al Farsi RS, et al. Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study. J Clin Med. 2023;12(16):5346.Al HuraiziARAl-MaqbaliJSAl FarsiRSDelirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective StudyJ Clin Med202312165346Search in Google Scholar
Nelson S, Muzyk AJ, Bucklin MH, Brudney S, Gagliardi JP. Defining the Role of Dexmedetomidine in the Prevention of Delirium in the Intensive Care Unit. BioMed Res Int. 2015;2015:635737.NelsonSMuzykAJBucklinMHBrudneySGagliardiJPDefining the Role of Dexmedetomidine in the Prevention of Delirium in the Intensive Care UnitBioMed Res Int20152015635737Search in Google Scholar
Daou M, Telias I, Younes M, Brochard L, Wilcox ME. Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?. Front Neurol. 2020;11:549908.DaouMTeliasIYounesMBrochardLWilcoxMEAbnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?Front Neurol202011549908Search in Google Scholar
Jeong IS, Cho MK. Factors Affecting Delirium in ICU Patients. Int J Environ Res Public Health. 2023;20(10):5889.JeongISChoMKFactors Affecting Delirium in ICU PatientsInt J Environ Res Public Health202320105889Search in Google Scholar
Tran A, Blinder H, Hutton B et al. Alpha-2 agonists for sedation in mechanically ventilated neurocritical care patients: a systematic review protocol. Syst Rev. 2016:5(1):154TranABlinderHHuttonBAlpha-2 agonists for sedation in mechanically ventilated neurocritical care patients: a systematic review protocolSyst Rev201651154Search in Google Scholar
Pedersen SS, Kirkegaard T, Jørgensen MB, Jørgensen VL. Effects of a screening and treatment protocol with haloperidol on post-cardiotomy delirium: a prospective cohort study. Interact Cardiovasc Thorac Surg. 2014;18(4):438–445.PedersenSSKirkegaardTJørgensenMBJørgensenVLEffects of a screening and treatment protocol with haloperidol on post-cardiotomy delirium: a prospective cohort studyInteract Cardiovasc Thorac Surg2014184438445Search in Google Scholar
Pisani MA, Araujo KL, Murphy TE. Association of cumulative dose of haloperidol with next-day delirium in older medical ICU patients. Crit. Care Med. 2015;43(5):996–1002.PisaniMAAraujoKLMurphyTEAssociation of cumulative dose of haloperidol with next-day delirium in older medical ICU patientsCrit. Care Med20154359961002Search in Google Scholar
van den Boogaard M, Schoonhoven L, van Achterberg T, van der Hoeven JG, Pickkers P. Haloperidol prophylaxis in critically ill patients with a high risk for delirium. Critical care. 2013;17(1):R9.van den BoogaardMSchoonhovenLvan AchterbergTvan der HoevenJGPickkersPHaloperidol prophylaxis in critically ill patients with a high risk for deliriumCritical care2013171R9Search in Google Scholar
Page VJ, Ely EW, Gates S, et al. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Lancet Respir. Med. 2013;1(7):515–523.PageVJElyEWGatesSEffect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trialLancet Respir. Med.201317515523Search in Google Scholar
Leuch S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet. 2013;382(9896):951–962.LeuchSCiprianiASpineliLComparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysisThe Lancet20133829896951962Search in Google Scholar
Tamang K, Kc B, Kuikel S, Thapa S. Haloperidol-induced sudden cardiac arrest in a recently detected HIV and hepatitis C patient: A unique case report. SAGE Open Med Case Rep. 2023;11:2050313X231220792.TamangKKcBKuikelSThapaSHaloperidol-induced sudden cardiac arrest in a recently detected HIV and hepatitis C patient: A unique case reportSAGE Open Med Case Rep2023112050313X231220792Search in Google Scholar
Collet MO, Caballero J, Sonneville R, et al. Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study. Intensive Care Med 2018; 44(7): 1081–1089.ColletMOCaballeroJSonnevilleRPrevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort studyIntensive Care Med201844710811089Search in Google Scholar
Dotson B. Comparing Dexmedetomidine With Haloperidol for the Treatment of Hyperactive Delirium in Nonintubated ICU Patients. Crit Care Med. 2016;44(12):1259–60.DotsonBComparing Dexmedetomidine With Haloperidol for the Treatment of Hyperactive Delirium in Nonintubated ICU PatientsCrit Care Med20164412125960Search in Google Scholar
Keating GM. Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting. Drugs. 2015;75(10):1119–30.KeatingGMDexmedetomidine: A Review of Its Use for Sedation in the Intensive Care SettingDrugs20157510111930Search in Google Scholar
Reade MC, Eastwood GM, Bellomo R, et al. Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial. JAMA. 2016;315(14):1460–8.ReadeMCEastwoodGMBellomoREffect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical TrialJAMA20163151414608Search in Google Scholar
Jalonen J, Hynynen M, Kuitunen A, et al. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology. 1997;86:331–345.JalonenJHynynenMKuitunenADexmedetomidine as an anesthetic adjunct in coronary artery bypass graftingAnesthesiology199786331345Search in Google Scholar
Kim Y, Kim SY, Lee JS, Kong HJ, Han DW. Effect of dexmedetomidine on the corrected QT and Tp-e intervals during spinal anesthesia. Yonsei Med J. 2014;55(2):517–522.KimYKimSYLeeJSKongHJHanDWEffect of dexmedetomidine on the corrected QT and Tp-e intervals during spinal anesthesiaYonsei Med J2014552517522Search in Google Scholar
Raschi E, Poluzzi E, Godman B, et al. Torsadogenic Risk of Antipsychotics: Combining Adverse Event Reports with Drug Utilization Data across Europe. PLoS ONE 2013;8(11):81208.RaschiEPoluzziEGodmanBTorsadogenic Risk of Antipsychotics: Combining Adverse Event Reports with Drug Utilization Data across EuropePLoS ONE201381181208Search in Google Scholar
Metzger E, Friedman R. Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill. Journal of Clin. Psychopharmacol. 1993;13(2):128–132.MetzgerEFriedmanRProlongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically illJournal of Clin. Psychopharmacol.1993132128132Search in Google Scholar
Perrault LP, Denault AY, Carrier M, Cartier R, Bélisle S. Torsades de pointes secondary to intravenous haloperidol after coronary bypass grafting surgery. Can J Anaesth. 2000;47(3):251–254.PerraultLPDenaultAYCarrierMCartierRBélisleSTorsades de pointes secondary to intravenous haloperidol after coronary bypass grafting surgeryCan J Anaesth2000473251254Search in Google Scholar
O’Brien JM, Rockwood RP, Suh KI. Haloperidol-induced torsade de pointes. Ann Pharmacother. 1999;33(10):1046–1050.O’BrienJMRockwoodRPSuhKIHaloperidol-induced torsade de pointesAnn Pharmacother1999331010461050Search in Google Scholar
Li M, Ramos LG. Drug-Induced QT Prolongation And Torsades de Pointes. P T. 2017;42(7):473–477.LiMRamosLGDrug-Induced QT Prolongation And Torsades de PointesP T2017427473477Search in Google Scholar
Drew BJ, Ackerman MJ, Funk M, et al. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2010;55(9):934–947.DrewBJAckermanMJFunkMPrevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology FoundationJ Am Coll Cardiol2010559934947Search in Google Scholar
Burns KM, Greene EA. Long QT syndrome unmasked by dexmedetomidine: a case report. Congenital heart disease. 2014;9(1):E11–E15.BurnsKMGreeneEALong QT syndrome unmasked by dexmedetomidine: a case reportCongenital heart disease201491E11E15Search in Google Scholar
Görges M, Whyte SD, Sanatani S, Dawes J, Montgomery CJ, Ansermino JM. Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study. Paediatric anaesthesia. 2015;25(12):1287–1293.GörgesMWhyteSDSanataniSDawesJMontgomeryCJAnserminoJMChanges in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective studyPaediatric anaesthesia2015251212871293Search in Google Scholar
Fujii E, Fujino K, Fujii M, Furuno M, Sugimoto Y, Takabuchi S, et al. Dexmedetomidine attenuates the positive chronotropic effects of intravenous atropine in patients with bradycardia during spinal anaesthesia: a retrospective study. JA Clinical Reports. 2018;4(1):1–6.FujiiEFujinoKFujiiMFurunoMSugimotoYTakabuchiSDexmedetomidine attenuates the positive chronotropic effects of intravenous atropine in patients with bradycardia during spinal anaesthesia: a retrospective studyJA Clinical Reports20184116Search in Google Scholar
Grmec S, Mally S, Klemen P. Glasgow Coma Scale score and QTc interval in the prognosis of organophosphate poisoning. Acad Emerg Med. 2004;11(9):925–930.GrmecSMallySKlemenPGlasgow Coma Scale score and QTc interval in the prognosis of organophosphate poisoningAcad Emerg Med2004119925930Search in Google Scholar
George TK, Chase D, Peter JV, et al. Association between a prolonged corrected QT interval and outcomes in patients in a medical Intensive Care Unit. Indian J Crit Care Med. 2015;19(6):326–332)GeorgeTKChaseDPeterJVAssociation between a prolonged corrected QT interval and outcomes in patients in a medical Intensive Care UnitIndian J Crit Care Med2015196326332Search in Google Scholar
Ye M, Zhang J, Liu J, Zhang M, Yao F, & Cheng Y. Association Between Dynamic Change of QT Interval and Long-Term Cardiovascular Outcomes: A Prospective Cohort Study. Front Cardiovasc Med. 2021;8:756213.YeMZhangJLiuJZhangMYaoFChengYAssociation Between Dynamic Change of QT Interval and Long-Term Cardiovascular Outcomes: A Prospective Cohort StudyFront Cardiovasc Med20218756213Search in Google Scholar
Rabkin SW, Cheng BJ, Thompson DJ. Detailed analysis of the impact of age on the QT interval. J Geriatr Cardiol. 2016;13(9):740–748.RabkinSWChengBJThompsonDJDetailed analysis of the impact of age on the QT intervalJ Geriatr Cardiol2016139740748Search in Google Scholar