Hypothalamic-pituitary axis disorder – “the puppet master” of multiple organ dysfunction in brain-dead patients

1https://optn.transplant.hrsa.gov/learn/about-transplantation/history/https://optn.transplant.hrsa.gov/learn/about-transplantation/history/Search in Google Scholar

2Anwar ASMT, Lee JM. Medical Management of Brain-Dead Organ Donors. Acute Crit Care. 2019;34(1):14-29. doi:10.4266/ acc.2019.00430Anwar ASMT Lee JM Medical Management of Brain-Dead Organ Donors Acute Crit Care 201934 1 14 29 10.4266/acc.2019.00430684904331723901Open DOISearch in Google Scholar

3Nair-Collins M, Northrup J, Olcese J. Hypothalamic-Pituitary Function in Brain Death: A Review. J Intens Care Med. 2014. 31. 10.1177/0885066614527410Nair-Collins M Northrup J Olcese J Hypothalamic-Pituitary Function in Brain Death: A Review J Intens Care Med 2014 31 10.1177/088506661452741024692211Open DOISearch in Google Scholar

4Chamorro-Jambrina C, Muñoz-Ramírez MR, Martínez-Melgar JL, Pérez-Cornejo MS. Organ donor management: Eight common recommendations and actions that deserve reflection. Med Intensiva. 2017;41(9):559-568. doi:10.1016/j. medin.2017.01.012Chamorro-Jambrina C Muñoz-Ramírez MR Martínez-Melgar JL Pérez-Cornejo MS Organ donor management: Eight common recommendations and actions that deserve reflection Med Intensiva 201741 9 559 568 10.1016/j.medin.2017.01.01228318674Open DOISearch in Google Scholar

5Hahnenkamp K, Böhler K, Wolters H, et al., Organ-Protective Intensive Care in Organ Donors. Dtsch Arztebl Int. 2016;113(3334):552-558. doi:10.3238/arztebl.2016.0552Hahnenkamp K Böhler K Wolters H et al Organ-Protective Intensive Care in Organ Donors Dtsch Arztebl Int 2016113 3334 552 558 10.3238/arztebl.2016.0552501557727598872Open DOISearch in Google Scholar

6Shemie SD, Dhanani S, The Physiology of Brain Death and Organ Donor Management. Ped Crit Care Med. 2014 Jan 28:497–518. doi: 10.1007/978-1-4471-6362-6_38. Shemie SD Dhanani S The Physiology of Brain Death and Organ Donor Management Ped Crit Care Med 2014 Jan 28497 518 10.1007/978-1-4471-6362-6_38Open DOISearch in Google Scholar

7Kuecuek O, Mantouvalou L, Klemz R, et al. Significant reduction of proinflammatory cytokines by treatment of the human brain dead donor. Transplantation. 2004; 78(2):197.Kuecuek O Mantouvalou L Klemz R et al Significant reduction of proinflammatory cytokines by treatment of the human brain dead donor Transplantation 2004 78 2 19710.1097/00007890-200407271-00516Search in Google Scholar

8Mi Z, Novitzky D, Collins J, et al. The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors. Clin Epidemiol. 2015;7:17-27.Mi Z Novitzky D Collins J et al The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors Clin Epidemiol 2015717 2710.2147/CLEP.S71403427873325565890Search in Google Scholar

9Lindner G, Funk GC. Hypernatremia in critically ill patients. J Crit Care. 2013;28(2):216.e11-216.e2.16E20. doi:10.1016/j. jcrc.2012.05.001.Lindner G Funk GC Hypernatremia in critically ill patients J Crit Care 201328 2 216e11-216.e2.16E20 10.1016/j.jcrc.2012.05.00122762930Open DOISearch in Google Scholar

10Opdam HI, Hormonal Therapy in Organ Donors. Crit Care Clin. 2019;35(2):389-405. doi:10.1016/j.ccc.2018.11.013.Opdam HI Hormonal Therapy in Organ Donors Crit Care Clin 201935 2 389 405 10.1016/j.ccc.2018.11.01330784617Open DOISearch in Google Scholar

11Bajwa SJ, Haldar R, Brain death in ICU patients: Clinical significance of endocrine changes. Indian J Endocrinol Metab. 2014;18(2):229-231. doi:10.4103/2230-8210.129118Bajwa SJ Haldar R Brain death in ICU patients: Clinical significance of endocrine changes Indian J Endocrinol Metab 201418 2 229 231 10.4103/2230-8210.129118398727724741523Open DOISearch in Google Scholar

12Buchanan IA, Mehta VA, Thyroid hormone resuscitation after brain death in potential organ donors: A primer for neurocritical care providers and narrative review of the literature. Clin Neurol Neurosurg. 2018;165:96-102. doi:10.1016/j.clineuro.2018.01.004.Buchanan IA Mehta VA Thyroid hormone resuscitation after brain death in potential organ donors: A primer for neurocritical care providers and narrative review of the literature Clin Neurol Neurosurg 201816596 102 10.1016/j.clineuro.2018.01.00429331874Open DOISearch in Google Scholar

13Akbaş T, İbrahim EŞ, Ayhan Ö. Alterations in thyroid hormones in brain-dead patients are related to non-thyroidal illness syndrome. Endokrynologia Polska. 2018;69(5). DOI: 10.5603/EP.a2018.0056.Akbaş T İbrahim EŞ Ayhan Ö Alterations in thyroid hormones in brain-dead patients are related to non-thyroidal illness syndrome Endokrynologia Polska 201869 5 10.5603/EP.a2018.005630132587Open DOISearch in Google Scholar

14Kotsch K, Ulrich F, Reutzel-Selke A, et al. Methylprednisolone therapy in deceased donors reduces inflammation in the donor liver and improves outcome after liver transplantation: a prospective randomized controlled trial [published correction appears in Ann Surg. 2011 Aug;254(2):391]. Ann Surg. 2008;248(6):1042-1050. doi:10.1097/SLA.0b013e31819 0e70c.Kotsch K Ulrich F Reutzel-Selke A et al Methylprednisolone therapy in deceased donors reduces inflammation in the donor liver and improves outcome after liver transplantation: a prospective randomized controlled trial [published correction appears in Ann Surg 2011 Aug;254(2):391]. Ann Surg. 2008248 6 1042 1050 10.1097/SLA.0b013e318190e70c19092349Open DOISearch in Google Scholar

15Meyfroidt G, Gunst J, Martin-Loeches I, et al. Management of the brain-dead donor in the ICU: general and specific therapy to improve transplantable organ quality. Intensive Care Med. 2019;45(3):343-353. doi:10.1007/s00134-019-05551-y.Meyfroidt G Gunst J Martin-Loeches I et al Management of the brain-dead donor in the ICU: general and specific therapy to improve transplantable organ quality Intensive Care Med 201945 3 343 353 10.1007/s00134-019-05551-y709537330741327Open DOISearch in Google Scholar

16Anwar A.S.M.T., Lee J.M., Medical Management of Brain-Dead Organ Donors. Acute Crit Care. 2019;34(1):14-29. doi:10.4266/acc.2019.00430.Anwar A.S.M.T. Lee J.M. Medical Management of Brain-Dead Organ Donors Acute Crit Care 201934 1 14 29 10.4266/acc.2019.00430684904331723901Open DOISearch in Google Scholar