<abstract xmlns="http://www.w3.org/1999/xhtml">
<sec id="j_jccm-2021-0028_s_006">
<h3>Introduction</h3>
<p>Postoperative anaemia can affect more than 90% of patients undergoing major surgeries. Patients develop an absolute iron deficiency in the face of significant blood loss or preoperative anaemia and major surgery. Studies have shown the negative impact of these factors on transfusion requirements, infections, increased hospitalisation and long-term morbidities.</p></sec>
<sec id="j_jccm-2021-0028_s_007">
<h3>Aim of the study</h3>
<p>The research was performed to determine the correlation between intravenous iron administration in the postoperative period and improved haemoglobin correction trend.</p></sec>
<sec id="j_jccm-2021-0028_s_008">
<h3>Material and methods</h3>
<p>A prospective study was conducted to screen and treat iron deficiency in patients undergoing major surgery associated with significant bleeding. For iron deficiency anaemia screening, in the postoperative period, the following bioumoral parameters were assessed: haemoglobin, serum iron, transferrin saturation (TSAT), and ferritin, direct serum total iron-binding capacity (dTIBC), mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH). In addition, serum glucose, fibrinogen, urea, creatinine and lactate values were also collected.</p></sec>
<sec id="j_jccm-2021-0028_s_009">
<h3>Results</h3>
<p>Twenty-one patients undergoing major surgeries (52,38% were emergency and 47,61% elective interventions) were included in the study. Iron deficiency, as defined by ferritin 100-300 μg/L along with transferrin saturation (TSAT) &lt; 20 %, mean corpuscular volume (MVC) &lt; 92 fL, mean corpuscular haemoglobin (MCH) &lt; 33 g/dL, serum iron &lt; 10 μmol/L and direct serum total iron-binding capacity (dTIBC) > 36 μmol/L, was identified in all cases. To correct the deficit and optimise the haematological status, all patients received intravenous ferric carboxymaltose (500-1000 mg, single dose). Using Quadratic statistical analysis, the trend of haemoglobin correction was found to be a favourable one.</p></sec>
<sec id="j_jccm-2021-0028_s_010">
<h3>Conclusion</h3>
<p>The administration of intravenous ferric carboxymaltose in the postoperative period showed the beneficial effect of this type of intervention on the haemoglobin correction trend in these groups of patients.</p>
</sec>
</abstract>

Introduction
Postoperative anaemia can affect more than 90% of patients undergoing major surgeries. Patients develop an absolute iron deficiency in the face of significant blood loss or preoperative anaemia and major surgery. Studies have shown the negative impact of these factors on transfusion requirements, infections, increased hospitalisation and long-term morbidities.

Aim of the study
The research was performed to determine the correlation between intravenous iron administration in the postoperative period and improved haemoglobin correction trend.

Material and methods
A prospective study was conducted to screen and treat iron deficiency in patients undergoing major surgery associated with significant bleeding. For iron deficiency anaemia screening, in the postoperative period, the following bioumoral parameters were assessed: haemoglobin, serum iron, transferrin saturation (TSAT), and ferritin, direct serum total iron-binding capacity (dTIBC), mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH). In addition, serum glucose, fibrinogen, urea, creatinine and lactate values were also collected.

Results
Twenty-one patients undergoing major surgeries (52,38% were emergency and 47,61% elective interventions) were included in the study. Iron deficiency, as defined by ferritin 100-300 μg/L along with transferrin saturation (TSAT) < 20 %, mean corpuscular volume (MVC) < 92 fL, mean corpuscular haemoglobin (MCH) < 33 g/dL, serum iron < 10 μmol/L and direct serum total iron-binding capacity (dTIBC) > 36 μmol/L, was identified in all cases. To correct the deficit and optimise the haematological status, all patients received intravenous ferric carboxymaltose (500-1000 mg, single dose). Using Quadratic statistical analysis, the trend of haemoglobin correction was found to be a favourable one.

Conclusion
The administration of intravenous ferric carboxymaltose in the postoperative period showed the beneficial effect of this type of intervention on the haemoglobin correction trend in these groups of patients.

The Importance of Iron Administration in Correcting Anaemia after Major Surgery

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"The Importance of Iron Administration in Correcting Anaemia after Major Surgery"}

Introduction
Postoperative anaemia can affect more than 90% of patients undergoing major surgeries. Patients develop an absolute iron deficiency in the face of significant blood loss or preoperative anaemia and major surgery. Studies have shown the negative impact of these factors on transfusion requirements, infections, increased hospitalisation and long-term morbidities.

Aim of the study
The research was performed to determine the correlation between intravenous iron administration in the postoperative period and improved haemoglobin correction trend.

Material and methods
A prospective study was conducted to screen and treat iron deficiency in patients undergoing major surgery associated with significant bleeding. For iron deficiency anaemia screening, in the postoperative period, the following bioumoral parameters were assessed: haemoglobin, serum iron, transferrin saturation (TSAT), and ferritin, direct serum total iron-binding capacity (dTIBC), mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH). In addition, serum glucose, fibrinogen, urea, creatinine and lactate values were also collected.

Results
Twenty-one patients undergoing major surgeries (52,38% were emergency and 47,61% elective interventions) were included in the study. Iron deficiency, as defined by ferritin 100-300 μg/L along with transferrin saturation (TSAT)  36 μmol/L, was identified in all cases. To correct the deficit and optimise the haematological status, all patients received intravenous ferric carboxymaltose (500-1000 mg, single dose). Using Quadratic statistical analysis, the trend of haemoglobin correction was found to be a favourable one.

Conclusion
The administration of intravenous ferric carboxymaltose in the postoperative period showed the beneficial effect of this type of intervention on the haemoglobin correction trend in these groups of patients.

Introduction
Postoperative anaemia can affect more than 90% of patients undergoing major surgeries. Patients develop an absolute iron deficiency in the face of...

The Importance of Iron Administration in Correcting Anaemia after Major Surgery

Article Category: Research Article

Pubblicato online: 05 ago 2021

Pagine: 184 - 191

Ricevuto: 30 giu 2021

Accettato: 21 lug 2021

DOI: https://doi.org/10.2478/jccm-2021-0028

Parole chiave
major surgery, anaemia, postoperative iron deficiency, intravenous iron therapy

© 2021 Mirela Tiglis, Cristian Cobilinschi, Liliana Elena Mirea, Alexandru Emil Băetu, Ileana Peride, Tiberiu Paul Neagu, Andrei Niculae, Ionel Alexandru Checherită, Ioana Marina Grintescu, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The Importance of Iron Administration in Correcting Anaemia after Major Surgery

Article Category: Research Article

Pubblicato online: 05 ago 2021

Pagine: 184 - 191

Ricevuto: 30 giu 2021

Accettato: 21 lug 2021

DOI: https://doi.org/10.2478/jccm-2021-0028

Parole chiavemajor surgery, anaemia, postoperative iron deficiency, intravenous iron therapy

© 2021 Mirela Tiglis, Cristian Cobilinschi, Liliana Elena Mirea, Alexandru Emil Băetu, Ileana Peride, Tiberiu Paul Neagu, Andrei Niculae, Ionel Alexandru Checherită, Ioana Marina Grintescu, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Parole chiave
major surgery, anaemia, postoperative iron deficiency, intravenous iron therapy