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Candida spp. in Lower Respiratory Tract Secretions – A Ten Years Retrospective Study

Cristina Nicoleta Ciurea
Cristina Nicoleta Ciurea
, 
Ario Santini
Ario Santini
, 
Anca Delia Mare
Anca Delia Mare
, 
Irina Bianca Kosovski
Irina Bianca Kosovski
, 
Felicia Toma
Felicia Toma
, 
Camelia Vintila
Camelia Vintila
, 
Ionela Anca Pintea-Simon
Ionela Anca Pintea-Simon
 e 
Adrian Man
Adrian Man
   | 05 ago 2021
The Journal of Critical Care Medicine's Cover Image
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Article Category: Research Article
Pubblicato online: 05 ago 2021
Pagine: 217 - 226
Ricevuto: 17 mar 2021
Accettato: 24 mag 2021
DOI: https://doi.org/10.2478/jccm-2021-0016
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© 2021 Cristina Nicoleta Ciurea, Ario Santini, Anca Delia Mare, Irina Bianca Kosovski, Felicia Toma, Camelia Vintila, Ionela Anca Pintea-Simon, Adrian Man, published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Fig. 1

Flowchart of processed samples
Flowchart of processed samples

Fig. 2

Candida spp. in the total number of lower respiratory tract samples compared to the non-contaminated samples
Candida spp. in the total number of lower respiratory tract samples compared to the non-contaminated samples

Candida spp. - positive tracheal aspirate and sputum samples; n represents the number of analysed data after exclusion of incomplete data; CI (confidence interval); p (p-value), n represents the number of analysed data

n Tracheal aspirate Sputum samples p OR
Age > 60 years old<= 60 years old 544 322 (32.07%)138 (13.75%) 317 (31.57%)227 (22.61%) 0.0001 1.671(CI 1.285-2.172)
Gender FemaleMale 893 182 (16.01%)342 (30.08%) 195 (17.15%)418 (36.76%) 0.3122 1.141(CI 0.8906-1.461)
Candida spp. C. albicansC. non-albicans 470 224 (24.27%)229 (24.81%) 281 (30.44%)189 (20.48%) 0.0019 0.6579(CI 0.5069-0.8538)
The number of Candida spp. One speciesTwo and more species 589 453 (39.56%)78 (6.81%) 470 (41.05%)144 (12.58%) 0.0002 1.779(CI 1.312-2.412)

Contaminated and non-contaminated sputum samples that showed Candida growth; n represents the number of analysed data after exclusion of incomplete data; OR (odds ratio); CI (confidence interval); p (p-value)

Frequency and Percentage
Parameter Contaminated sputum samples Non-contaminated sputum samples p OR
Age n=544 > 40 years old 197 (36.21%) 286 (52.57%) 0.0189 1.954
<= 40 years old 35 (6.43%) 26 (4.78%) (CI 1.140-3.35)
> 60 years old 126 (23.16%) 191 (35.11%) 0.753
<= 60 years old 106 (19.49%) 121 (22.24%) 0.114 (CI 0.5336-1.063)
> 80 years old 12 (2.21%) 26 (4.78%) 1.667 (CI 0.822 -
<= 80 years old 220 (40.44%) 286 (52.57%) 0.175 3.378)
Gender n=612 Female 86 (14.05%) 109 (17.81%) 1.124
Male 172 (28.10%) 245 (40.03%) 0.5389 (CI 0.7971-1.584)
Candida spp. n=470 C. albicans 122 (25.96%) 159 (33.83%) 0.0004 0.5048
C. non-albicans 114 (24.26%) 75 (15.96%) (CI 0.3469-0.7345)
The number of n=589 One species 197 (33.45%) 273 (46.35%) 1.1599
Candida spp. Two species and more 37 (6.28%) 82 (13.92%) 0.0358 (CI 1.041-2.457)

Comparison of different Candida spp. in LRTS

C. albicans C. non-albicans C. albicans and C. non-albicans
Number of samples 445 357 70
Mean 61.51 65.76 64.42
Standard Deviation 16.293 13.744 15.63
Median 64 69 69
Min 6 21 12
Max 94 99 88
Normal distribution no no yes
eISSN:
2393-1817
Lingua:
Inglese
Frequenza di pubblicazione:
4 volte all'anno
Argomenti della rivista:
Medicine, Clinical Medicine, Internal Medicine, other, Surgery, Anaesthesiology, Emergency Medicine and Intensive-Care Medicine
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