Renal Recovery in Critically Ill Adult Patients Treated With Veno-Venous or Veno-Arterial Extra Corporeal Membrane Oxygenation: A Retrospective Cohort Analysis
, , , , e | 12 mag 2021
INFORMAZIONI SU QUESTO ARTICOLO
Article Category: Research Article
Pubblicato online: 12 mag 2021
Pagine: 104 - 112
Ricevuto: 08 ott 2020
Accettato: 27 gen 2021
DOI: https://doi.org/10.2478/jccm-2021-0006
Parole chiave
© 2021 Braghadheeswar Thyagarajan, Mariana Murea, Deanna N. Jones, Amit K. Saha, Gregory B. Russell, Ashish K. Khanna, published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Fig.1
Fig. 2
Distribution of Acute Kidney Injury Risk Factors
| Factor | VA ECMO | VV ECMO | Odds Ratio of AKI (95% CI) | p-value |
|---|---|---|---|---|
| IV contrast scan (%) | 37 (64%) | 33 (65%) | 0.96 (0.44, 2.11) | 0.92 |
| Cardiopulmonary Bypass (%) | 14 (24%) | 1 (2%) | 15.9 (2.0, 125.9) | 0.0088 |
| NSAID (%) | 9 (16%) | 15 (29%) | 0.44 (0.17, 1.12) | 0.085 |
| Antibiotics (%) | 32 (55%) | 29 (57%) | 0.93 (0.44, 1.99) | 0.86 |
| Sepsis (%) | 5 (9%) | 12 (24%) | 0.31 (0.10, 0.94) | 0.039 |
| Hypotension (%) | 49 (84%) | 35 (69%) | 2.49 (0.99, 6.28) | 0.053 |
| Vasopressor dependent Hypotension (%) | 38 (66%) | 31 (61%) | 1.23 (0.56, 2.68) | 0.61 |
| CHF (%) | 14 (24%) | 10 (20%) | 1.31 (0.52, 3.26) | 0.57 |
Renal Outcomes by Type of ECMO Support
| VA ECMO | VV ECMO | p-value | |
|---|---|---|---|
| Complete Renal Recovery | 15 (26%) | 22 (43%) | 0.07 |
| Partial Renal Recovery | 5 (9%) | 3 (6%) | 0.72 |
| Dialysis Dependent | 1 (2%) | 1 (2%) | >0.99 |
| Death | 37 (64%) | 25 (49%) | 0.13 |
Primary Diagnosis of VA and VV ECMO groups
| Primary Diagnosis | VA ECMO | VV ECMO |
|---|---|---|
| Acute Coronary Syndrome | 27 | 0 |
| Congestive heart failure | 9 | 0 |
| Sepsis | 5 | 12 |
| Cardiac arrest | 5 | 0 |
| Valvular heart disease | 4 | 0 |
| Pulmonary embolism | 3 | 0 |
| Cardiac arrhythmias | 3 | 0 |
| Others | 8 | 15 |
| Pneumonia | 0 | 10 |
| Trauma | 0 | 10 |
| Viral Pneumonia | 0 | 5 |
| Drug Overdose | 0 | 3 |
| Acute Pancreatitis | 0 | 2 |
| Asthma | 0 | 1 |
Baseline Patient Characteristics by Type of ECMO Support
| VA ECMO | VV ECMO | p-Value | |
|---|---|---|---|
| Total Number | 64 | 58 | |
| Age, mean (SD), years | 55.4 (15.8) | 42.9 (16.2) | <0.0001 |
| Male sex, n (%) | 50 (78%) | 40 (70%) | 0.21 |
| White race, n (%) | 46 (79%) | 36 (71%) | 0.37 |
| BMI, mean (SD) | 32.9 (9.0) | 30.4 (8.1) | 0.30 |
| Smoking – No | 59 (92%) | 49 (84%) | 0.26 |
| Diabetes mellitus, n (%) | 4 (6%) | 6 (10%) | 0.52 |
| CAD, n (%) | 14 (22%) | 4 (7%) | 0.023 |
| HTN, n (%) | 16 (25%) | 15 (26%) | >0.99 |
| CKD, n (%) | 10 (16%) | 3 (5%) | 0.080 |
| Hyperlipidaemia, n (%) | 14 (22%) | 5 (9%) | 0.049 |
| COPD, n (%) | 7 (11%) | 6 (10%) | >0.99 |
| APACHE II, mean (SD) | 24.8 (7.9) | 28.0 (6.2) | 0.014 |
| Charlson Comorbidity Index, mean (SD) | 2.4 (2.7) | 1.8 (3.0) | 0.27 |
| Lactic acid, mean (SD), mmol/L | 7.4 (4.4) | 4.4 (3.2) | 0.0002 |
| ICU length of stay, mean (SD), days | 11.6 (10.8) | 24.5 (15.4) | <0.0001 |
| AKI, all stage, n (%) | 58 (91%) | 51 (88%) | 0.77 |