<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jccm-2020-0048_s_006">
<h3>Introduction</h3>
<p>Positive fluid status has been associated with a worse prognosis in intensive care unit (ICU) patients. Given the potential for errors in the calculation of fluid balance totals and the problem of accounting for indiscernible fluid losses, measurement of body weight change is an alternative non-invasive method commonly used for estimating body fluid status. The objective of the study is to compare the measurements of fluid balance and body weight changes over time and to assess their association with ICU mortality.</p></sec>
<sec id="j_jccm-2020-0048_s_007">
<h3>Methods</h3>
<p>This prospective observational study was conducted in the 34-bed multidisciplinary ICU of a tertiary teaching hospital in southern Brazil. Adult patients were eligible if their expected length of stay was more than 48 hours, and if they were not receiving an oral diet. Clinical demographic data, daily and cumulative fluid balance with and without indiscernible water loss, and daily and total body weight changes were recorded. Agreement between daily fluid balance and body weight change, and between cumulative fluid balance and total body weight change were calculated.</p></sec>
<sec id="j_jccm-2020-0048_s_008">
<h3>Results</h3>
<p>Cumulative fluid balance and total body weight change differed significantly among survivors and non survivors respectively, +2.53L versus +5.6L (p= 0.012) and -3.05kg vs -1.1kg (p= 0.008). The average daily difference between measured fluid balance and body weight was +0.864 L/kg with a wide interval: -3.156 to +4.885 L/kg, which remained so even after adjustment for indiscernible losses (mean bias: +0.288; limits of agreement between -3.876 and +4.452 L/kg). Areas under ROC curve for cumulative fluid balance, cumulative fluid balance with indiscernible losses and total body weight change were, respectively, 0.65, 0.56 and 0.65 (p= 0.14).</p></sec>
<sec id="j_jccm-2020-0048_s_009">
<h3>Conclusion</h3>
<p>The results indicated the absence of correspondence between fluid balance and body weight change, with a more significant discrepancy between cumulative fluid balance and total body weight change. Both fluid balance and body weight changes were significantly different among survivors and non-survivors, but neither measurement discriminated ICU mortality.</p></sec>
</abstract>

Introduction
Positive fluid status has been associated with a worse prognosis in intensive care unit (ICU) patients. Given the potential for errors in the calculation of fluid balance totals and the problem of accounting for indiscernible fluid losses, measurement of body weight change is an alternative non-invasive method commonly used for estimating body fluid status. The objective of the study is to compare the measurements of fluid balance and body weight changes over time and to assess their association with ICU mortality.

Methods
This prospective observational study was conducted in the 34-bed multidisciplinary ICU of a tertiary teaching hospital in southern Brazil. Adult patients were eligible if their expected length of stay was more than 48 hours, and if they were not receiving an oral diet. Clinical demographic data, daily and cumulative fluid balance with and without indiscernible water loss, and daily and total body weight changes were recorded. Agreement between daily fluid balance and body weight change, and between cumulative fluid balance and total body weight change were calculated.

Results
Cumulative fluid balance and total body weight change differed significantly among survivors and non survivors respectively, +2.53L versus +5.6L (p= 0.012) and -3.05kg vs -1.1kg (p= 0.008). The average daily difference between measured fluid balance and body weight was +0.864 L/kg with a wide interval: -3.156 to +4.885 L/kg, which remained so even after adjustment for indiscernible losses (mean bias: +0.288; limits of agreement between -3.876 and +4.452 L/kg). Areas under ROC curve for cumulative fluid balance, cumulative fluid balance with indiscernible losses and total body weight change were, respectively, 0.65, 0.56 and 0.65 (p= 0.14).

Conclusion
The results indicated the absence of correspondence between fluid balance and body weight change, with a more significant discrepancy between cumulative fluid balance and total body weight change. Both fluid balance and body weight changes were significantly different among survivors and non-survivors, but neither measurement discriminated ICU mortality.

The Correspondence between Fluid Balance and Body Weight Change Measurements in Critically Ill Adult Patients

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

Introduction
Positive fluid status has been associated with a worse prognosis in intensive care unit (ICU) patients. Given the potential for errors in the...

The Correspondence between Fluid Balance and Body Weight Change Measurements in Critically Ill Adult Patients

Article Category: Research Article

Pubblicato online: 29 gen 2021

Pagine: 46 - 53

Ricevuto: 23 giu 2020

Accettato: 08 dic 2020

DOI: https://doi.org/10.2478/jccm-2020-0048

Parole chiave
fluid balance, body weight change, critical illness

© 2021 Ana Carolina Peçanha Antonio, Vivian Rodrigues Fernandes, Karina de Oliveira Azzolin, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The Correspondence between Fluid Balance and Body Weight Change Measurements in Critically Ill Adult Patients

Article Category: Research Article

Pubblicato online: 29 gen 2021

Pagine: 46 - 53

Ricevuto: 23 giu 2020

Accettato: 08 dic 2020

DOI: https://doi.org/10.2478/jccm-2020-0048

Parole chiavefluid balance, body weight change, critical illness

© 2021 Ana Carolina Peçanha Antonio, Vivian Rodrigues Fernandes, Karina de Oliveira Azzolin, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Parole chiave
fluid balance, body weight change, critical illness