Chen et al. [29] | 99 | Elevated D-dimer - 36 (36%) Thrombocytopenia – 12 (12%) Prolonged aPTT – 6 (6%) Prolonged PT – 5 (5%) | The first study to report both the clinical and laboratory features of COVID-19 related illness. |
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Wang et al. [30] | 138 (ICU – 36, Non-ICU – 102) | Prolonged PT – 80 (58%) Elevated D-dimer - (26% of the patients from ICU) | 1 – The levels of D-dimer were significantly higher in ICU patients than non-ICU patients. (p<0.001)
2 – The levels of D-dimer were significantly higher in non-survivors than survivors. (p<0.05)
3 – D-dimer levels showed an increasing trend in patients who succumbed to the illness. |
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Zhou et al. [31] | 191 (Survivors -137, Non-survivors – 54) | Elevated D-dimer Survivors – 67 (57%) Non-survivors – 50 (92%) | 1 – A D-dimer level of >1.0 μg/mL at admission was associated with higher odds of mortality. OR=18.42 (p=0.0033)
2 – D-dimer levels were significantly higher in non-survivors than in survivors. (5.2 vs. 0.6, p<0.0001) |
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Huang et al. [32] | 41 (ICU – 13, Non-ICU – 28) | - | 1- Median D-dimer levels were significantly higher in ICU patients as compared to the non-ICU patients. (2.4 vs. 0.5, p=0.0042)
2 – Median prothrombin time was significantly higher in ICU patients as compared to the non-ICU patients. (12.2sec vs. 10.7sec, p=0.012) |
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Chen et al. [33] | 21 (Severe cases – 11, Moderate cases – 10) | - | Compared to moderate cases, severe cases had significantly elevated levels of D-dimer. (2.6 vs. 0.3, p=0.029) |
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Guan et al. [9] | 1099 | Elevated D-dimer 260/560 (46.4%) | D-dimer levels were significantly elevated in a higher proportion of patients with severe illness than those with non-severe illness. (59.6 % vs. 43.2 %, p = 0.0021) |
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Han et al. [34] | 94 patients 40 healthy controls | - | 1- D-dimer levels were significantly higher in the patient group than the healthy control group. (10.36 vs. 0.26, p<0.001)
2 – FDP levels were significantly higher in patients than in controls. (33.83 vs. 1.55mg/L, p<0.001)
3- Higher D-dimer and FDP levels were found to be predictive of severe disease. |
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Li et al [35] | 279 (Ordinary - 136 Improved - 23 Poor- 120) | - | The D-dimer levels on admission were significantly higher in the improved and poor group of patients than ordinary patients. (p<0.01) |
| | | Ordinary – Mild disease, subsidedImproved – First deteriorated, then improved gradually with treatment Poor – Deteriorated or died |
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Tang et al. [12] | 183 (Survivors – 162, Non-survivors – 21) | - | Abnormal coagulation tests (Elevated D-dimer, FDPs and decreased fibrinogen) were associated with a poorer prognosis, i.e. these parameters were significantly deranged in non-survivors than the survivors. |