Total no of patients | 122 | |
---|---|---|
Male | 66 | |
Female | 56 | |
Age | 55(4) years;[ mean(SD)] | |
BMI | 24.1(4.4); [mean(SD)] | |
Indications for vasopressor administration | ||
Septic shock | 89 | |
Cardiogenic shock | 7 | |
Stroke/Subarachnoid haemorrhage | 12 | |
Other | 14 |
Vasopressor combinations used | Number (n) of patients used |
---|---|
Noradrenaline – Adrenor (Samarth Life sciences, Mumbai, India) | 85 |
Adrenaline- Vasocon (Neon Laboratories, Palghar, India) | 2 |
Dopamine- Domin (Neon Laboratories, Palghar, India) | 2 |
Noradrenaline + Vasopressin- Cpressin-P (Samarth Life sciences, Mumbai, India) | 29 |
Noradrenaline + Adrenaline | 4 |
Vasopressor | Dilution | Dose |
---|---|---|
Noradrenaline Noradrenaline – Adrenor (Samarth Life sciences, Mumbai, India) | Single strength-2mg/48ml NS | 1ml=40 mcg |
Double strength-4mg /46ml NS | 1ml=80 mcg | |
Adrenaline Adrenaline- Vasocon (Neon Laboratories, Palghar, India) | Single strength-3mg/47ml NS | 1ml=60 mcg |
Double strength-6mg /44 ml NS | 1ml=120 mcg | |
Dopamine Dopamine- Domin (Neon Laboratories, Palghar, India) | 5ml/45ml NS, 5ml=200 mg | 1ml=4000 mcg (4mg) |
Vasopressin Vasopressin-Cpressin-P (Samarth Life sciences, Mumbai, India) | 20 units in 20 ml NS | 1ml=1 unit |
Grade | Clinical severity |
---|---|
0 | No symptoms |
1 | Skin blanched |
Oedema <1 inch in any direction | |
Cool to touch | |
With or without pain | |
2 | Skin blanched |
Oedema 1-6 inches in any direction | |
Cool to touch | |
With or without pain | |
3 | Skin blanched, translucent |
Gross oedema >6 inches in any direction | |
Cool to touch | |
Mild–moderate pain | |
Possible numbness | |
4 | Skin blanched, translucentSkintight, leaking |
Skin discoloured, bruised, swollen gross oedema | |
>6 inches | |
Deep pitting tissue oedema | |
Circulatory impairment | |
Moderate–severe pain | |
Infiltration of any amount of blood product, irritant, or vesicant |
Noradrenaline | Vasopressin | Adrenaline | Dopamine | |
---|---|---|---|---|
Number of Patients | 118/122 | 29/122 | 6/122 | 2/122 |
Duration-median(IQR) | 9 hours (6 – 14) | 4 hours (2.7 –9) | 6 hours (4-10) | 7.5hrs |
Initial dose-mean(SD) | 5.9(5.5)mcg/min | 1.9(0.2)U/hr | 5.2(1.7)mcg/min | 10mcg/kg/min |
Maximum dose - mean(SD) | 14.8(8.8)mcg/min | 2 (0.3)U/hr | 10.5(7.8) mcg/min | 10mcg/kg/min |
Total dose - mean(SD) | 10.6 (7) mcg/min | 1.9(0.25) U/hr | 6.3(2.8) mcg/min | 8.3mcg/kg/min |