This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
Alwood JS, Ronca AE, Mains RC, Shelhamer MJ, Smith JD, Goodwin TJ (2017) From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions. NPJ Microgravity 3: 510.1038/s41526-016-0002-828649627AlwoodJSRoncaAEMainsRCShelhamerMJSmithJDGoodwinTJ2017From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missionsNPJ Microgravity35Open DOISearch in Google Scholar
Bakos A, Varkonyi A, Minarovits J, Batkai L (2002) Effect of simulated microgravity on the production of IL-12 by PBMCs. Journal of Gravitational Physiology 9 (1): P293-294BakosAVarkonyiAMinarovitsJBatkaiL2002Effect of simulated microgravity on the production of IL-12 by PBMCsJournal of Gravitational Physiology91P293294Search in Google Scholar
Blue Origin (2016) New Shepard Payload User’s Guide for Research and Education Missions. NSPM-MA0002-B Rev B. Available at: https://www.blueorigin.com/Blue Origin2016New Shepard Payload User’s Guide for Research and Education MissionsNSPM-MA0002-B Rev B. Available athttps://www.blueorigin.com/Search in Google Scholar
Blue Origin (2017) New Shepard Payload User’s Guide for Research and Education Missions. NSPM-MA0002-C Rev C. Available at: https://www.blueorigin.com/Blue Origin2017New Shepard Payload User’s Guide for Research and Education MissionsNSPM-MA0002-C Rev C. Available athttps://www.blueorigin.com/Search in Google Scholar
Blue Origin (2018) New Shepard Payload User’s Guide for Research and Education Missions. NSPM-MA0002-E Rev E. Available at: https://www.blueorigin.com/Blue Origin2018New Shepard Payload User’s Guide for Research and Education MissionsNSPM-MA0002-E Rev E. Available athttps://www.blueorigin.com/Search in Google Scholar
Choi Y, Lee S, Kim K, Kim SH, Chung YJ, Lee C (2018) Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice. Experimental & Molecular Medicine 50(8): 99. doi:10.1038/s12276-018-0115-010.1038/s12276-018-0115-030089794ChoiYLeeSKimKKimSHChungYJLeeC2018Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized miceExperimental & Molecular Medicine5089910.1038/s12276-018-0115-0Open DOISearch in Google Scholar
Choudhry H, Helmi N, Abdulaal WH, Zeyadi M, Zamzami MA, Wu W, Mahmoud MM, Warsi MK, Rasool M, Jamal MS (2018) Prospects of IL-2 in cancer immunotherapy. Biomed Research International 905617329854806ChoudhryHHelmiNAbdulaalWHZeyadiMZamzamiMAWuWMahmoudMMWarsiMKRasoolMJamalMS2018Prospects of IL-2 in cancer immunotherapyBiomed Research International10.1155/2018/9056173Search in Google Scholar
Clément G (2017) International roadmap for artificial gravity research. NPJ Microgravity 3: 292918490310.1038/s41526-017-0034-8ClémentG2017International roadmap for artificial gravity researchNPJ Microgravity329Search in Google Scholar
Cogoli A (1997) Signal transduction in T lymphocytes in microgravity. Gravitational and Space Biology Bulletin: Publication of the American Society for Gravitational and Space Biology 10 (2), 5-16CogoliA1997Signal transduction in T lymphocytes in microgravityGravitational and Space Biology Bulletin: Publication of the American Society for Gravitational and Space Biology102516Search in Google Scholar
Crucian BE, Stowe RP, Pierson DL, Sams CF (2008) Immune system dysregulation following short- vs long-duration spaceflight. Aviation, Space and Environmental Medicine 79: 835-84310.3357/ASEM.2276.2008CrucianBEStoweRPPiersonDLSamsCF2008Immune system dysregulation following short- vs long-duration spaceflightAviation, Space and Environmental Medicine79835843Open DOISearch in Google Scholar
Eppendorf Handling Solutions. Basics in Centrifugation Available at: https://handlingsolutions.eppendorf.com/sample-handling/user-safety/safe-use-of-centrifuges/basics-in-centrifugation/ Accessed November 29, 2018Eppendorf Handling SolutionsBasics in CentrifugationAvailable athttps://handlingsolutions.eppendorf.com/sample-handling/user-safety/safe-use-of-centrifuges/basics-in-centrifugation/Accessed November 292018Search in Google Scholar
Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, Ferguson VL, Pecaut MJ (2009) Spaceflight effects on T lymphocyte distribution, function and gene expression. Journal of Applied Physiology 106: 194-20210.1152/japplphysiol.91126.2008GridleyDSSlaterJMLuo-OwenXRizviAChapesSKStodieckLSFergusonVLPecautMJ2009Spaceflight effects on T lymphocyte distribution, function and gene expressionJournal of Applied Physiology106194202Open DOISearch in Google Scholar
Grimm D, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, … Bauer J (2014) Growing tissues in real and simulated microgravity: new methods for tissue engineering. Tissue Engineering. Part B, Reviews 20(6): 555-566. doi:10.1089/ten.TEB.2013.070410.1089/ten.teb.2013.070424597549GrimmDWehlandMPietschJAleshchevaGWisePvan LoonJ…BauerJ2014Growing tissues in real and simulated microgravity: new methods for tissue engineeringTissue Engineering. Part B, Reviews20655556610.1089/ten.TEB.2013.0704Open DOISearch in Google Scholar
Hauschild S, Tauber S, Lauber B, Thiel CS, Layer LE, Ullrich O (2014) T cell regulation in microgravity—the current knowledge from in vitro experiments conducted in space, parabolic flights and ground-based facilities. Acta Astronautica 104: 365-37710.1016/j.actaastro.2014.05.019HauschildSTauberSLauberBThielCSLayerLEUllrichO2014T cell regulation in microgravity—the current knowledge from in vitro experiments conducted in space, parabolic flights and ground-based facilitiesActa Astronautica104365377Open DOISearch in Google Scholar
Kessler JO, Hill NA, Strittmater R, Wiseley D (1998) Sedimenting particles and swimming micro-organisms in a rotating fluid. Advances in Space Research 21(8/9): 1269-127510.1016/S0273-1177(97)00398-0KesslerJOHillNAStrittmaterRWiseleyD1998Sedimenting particles and swimming micro-organisms in a rotating fluidAdvances in Space Research218/912691275Open DOISearch in Google Scholar
Klaus DM (2001) Clinostats and bioreactors. Gravitational & Space Biology Bulletin 14(2): 55-64KlausDM2001Clinostats and bioreactorsGravitational & Space Biology Bulletin1425564Search in Google Scholar
Li Q, Mei Q, Huyan T, Xie L, Che S, Yang H, Zhang M, Huang Q (2013) Effects of simulated microgravity on primary human NK cells. Astrobiology 13(8): 703-71410.1089/ast.2013.098123919749LiQMeiQHuyanTXieLCheSYangHZhangMHuangQ2013Effects of simulated microgravity on primary human NK cellsAstrobiology138703714374621523919749Open DOISearch in Google Scholar
Licato LL, Grimm EA (1999) Multiple interleukin-2 signaling pathways differentially regulated by microgravity. Immunopharmacology 44: 273-2791059888410.1016/S0162-3109(99)00123-XLicatoLLGrimmEA1999Multiple interleukin-2 signaling pathways differentially regulated by microgravityImmunopharmacology44273279Search in Google Scholar
Mangala LS, ZhangY, He Z, Emami K, Ramesh GT, Story M, Rohde LH, Wu H (2011) Effects of simulated microgravity on expression profile of microRNA in human lymphoblastoid cells. Journal of Biological Chemistry 286(37): 32483-3249010.1074/jbc.M111.267765MangalaLSZhangYHeZEmamiKRameshGTStoryMRohdeLHWuH2011Effects of simulated microgravity on expression profile of microRNA in human lymphoblastoid cellsJournal of Biological Chemistry286373248332490317321321775437Open DOISearch in Google Scholar
Masopust D, Sivula CP, Jameson SC (2017) Of mice, dirty mice, and men: Using mice to understand human immunology. Journal of Immunology (Baltimore, MD: 1950) 199(2): 383-388. doi:10.4049/jimmunol.170045328696328MasopustDSivulaCPJamesonSC2017Of mice, dirty mice, and men: Using mice to understand human immunologyJournal of Immunology (Baltimore, MD: 1950)199238338810.4049/jimmunol.1700453551260228696328Search in Google Scholar
Manzano A, Herranz R, den Toom LA, te Slaa S, Borst G, Visser M, Medina FJ, van Loon JJWA (2018) Novel, Moon and Mars, partial gravity simulation paradigms and their effects on the balance between cell growth and cell proliferation during early plant development. NPJ Microgravity 4(1): 910.1038/s41526-018-0041-429644337ManzanoAHerranzRden ToomLAte SlaaSBorstGVisserMMedinaFJvan LoonJJWA2018Novel, Moon and Mars, partial gravity simulation paradigms and their effects on the balance between cell growth and cell proliferation during early plant developmentNPJ Microgravity419588478929644337Open DOISearch in Google Scholar
Martinez EM, Yoshida MC, Candelario TLT, Fulford MH (2015) Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation. American Journal of Physiology—Regulatory, Integrative and Comparative Physiology 308(6): R480-R48810.1152/ajpregu.00449.2014MartinezEMYoshidaMCCandelarioTLTFulfordMH2015Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activationAmerican Journal of Physiology—Regulatory, Integrative and Comparative Physiology3086R480R488436006625568077Open DOISearch in Google Scholar
Mehri R, Mavriplis C, Fenech M (2018) Red blood cell aggregates and their effect on non-Newtonian blood viscosity at low hematocrit in a two-fluid low shear rate microfluidic system. PLoS ONE 13(7): e0199911. doi:10.1371/journal.pone.019991110.1371/journal.pone.0199911MehriRMavriplisCFenechM2018Red blood cell aggregates and their effect on non-Newtonian blood viscosity at low hematocrit in a two-fluid low shear rate microfluidic systemPLoS ONE137e019991110.1371/journal.pone.0199911605315730024907Open DOISearch in Google Scholar
Moro-Aguilar R (2014) The new commercial suborbital vehicles: An opportunity for scientific and microgravity research. Microgravity Science and Technology 26: 219-22710.1007/s12217-014-9378-9Moro-AguilarR2014The new commercial suborbital vehicles: An opportunity for scientific and microgravity researchMicrogravity Science and Technology26219227Open DOISearch in Google Scholar
NASA (2016) Evidence Report: Risk of Radiation CarcinogenesisHuman Research Program Space Houston: Radiation ElementNASA2016Evidence Report: Risk of Radiation Carcinogenesis. Human Research Program SpaceHoustonRadiation ElementSearch in Google Scholar
Nickerson CA, Pellis NR, Ott CM (2016) Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells New York: Springer-Verlag. ISBN 978-1-4939-3276-4NickersonCAPellisNROttCM2016Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial CellsNew YorkSpringer-VerlagISBN 978-1-4939-3276-410.1007/978-1-4939-3277-1Search in Google Scholar
Paulsen K, Thiel C, Timm J, Schmidt PM, Huber K, Tauber S, Hemmersbach R, Seibt D, Kroll H, Grote K, Zipp F, Schneider-Stock R, Cogoli A, Hilliger A, Engelmann F, Ullrich O (2010) Microgravity-induced alterations in signal transduction in cells of the immune system. Acta Astronautica 67:1116–112510.1016/j.actaastro.2010.06.053PaulsenKThielCTimmJSchmidtPMHuberKTauberSHemmersbachRSeibtDKrollHGroteKZippFSchneider-StockRCogoliAHilligerAEngelmannFUllrichO2010Microgravity-induced alterations in signal transduction in cells of the immune systemActa Astronautica6711161125Open DOISearch in Google Scholar
Pletser V, Migeotte PF, Legros JC, Deneyer B, Caron R (2016) The Suborbital Research Association: using suborbital platforms for science and student experiments. Microgravity Science and Technology 28(5): 529-54410.1007/s12217-016-9502-0PletserVMigeottePFLegrosJCDeneyerBCaronR2016The Suborbital Research Association: using suborbital platforms for science and student experimentsMicrogravity Science and Technology285529544Open DOISearch in Google Scholar
Rubinstein MP, Su EW, Suriano S, Cloud CA, Andrijauskaite K, Kesarwani P, Schwartz KM, Williams KM, Johnson CB, Li M, Scurti GM, Salem ML, Paulos CM, Garrett-Mayer E, Mehrotra S, Cole DJ (2015) Interluekin-12 enhances the function and anti-tumor activity in murine and human CD8+ T cells. Cancer Immunology, Immunotherapy 64(5): 539-54910.1007/s00262-015-1655-yRubinsteinMPSuEWSurianoSCloudCAAndrijauskaiteKKesarwaniPSchwartzKMWilliamsKMJohnsonCBLiMScurtiGMSalemMLPaulosCMGarrett-MayerEMehrotraSColeDJ2015Interluekin-12 enhances the function and anti-tumor activity in murine and human CD8+ T cellsCancer Immunology, Immunotherapy645539549480487225676709Open DOISearch in Google Scholar
Sherman E, Barr V and Samelson LE (2013) Super-resolution characterization of TCR-dependent signaling clusters. Immunological Reviews 251(1): 21-3510.1111/imr.1201023278738ShermanEBarrVSamelsonLE2013Super-resolution characterization of TCR-dependent signaling clustersImmunological Reviews25112135353923823278738Open DOISearch in Google Scholar
Singh KP, Kumari R and Dumond J W (2010) Simulated microgravity-induced epigenetic changes in human lymphocytes. Journal of Cellular Biochemistry 111(1): 123-12910.1002/jcb.2267420506542SinghKPKumariRDumondJ W2010Simulated microgravity-induced epigenetic changes in human lymphocytesJournal of Cellular Biochemistry111112312920506542Open DOISearch in Google Scholar
Tauber S, Hauschild S, Crescio C, Secchi C, Paulsen K, Pantaleo A, Saba A, Buttron I, Thiel CS, Cogoli A, Pippia P, Ullrich O (2013) Signal transduction in primary human T lymphocytes in altered gravity—results of the MASER-12 suborbital space flight mission. Cell Communication and Signaling 11(1): 3210.1186/1478-811X-11-32TauberSHauschildSCrescioCSecchiCPaulsenKPantaleoASabaAButtronIThielCSCogoliAPippiaPUllrichO2013Signal transduction in primary human T lymphocytes in altered gravity—results of the MASER-12 suborbital space flight missionCell Communication and Signaling11132365371423651740Open DOISearch in Google Scholar
Thiel CS, Paulsen K, Bradacs G, Lust K, Tauber S, Dumrese C, Hilliger A, Schoppmann K, Biskup J, Gölz N, Sang C, Ziegler U, Grote KH, Zipp F, Zhuang F, Engelmann F, Hemmersbach R, Cogoli A, Ullrich O (2012) Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravity. Cell Communication and Signaling 10(1): 110.1186/1478-811X-10-1ThielCSPaulsenKBradacsGLustKTauberSDumreseCHilligerASchoppmannKBiskupJGölzNSangCZieglerUGroteKHZippFZhuangFEngelmannFHemmersbachRCogoliAUllrichO2012Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravityCell Communication and Signaling1011327551322273506Open DOISearch in Google Scholar
Thiel CS, Hauschild S, Huge A, Tauber S, Lauber BA, Polzer J, Paulsen K, Lier H, Engelmann F, Schmitz B, Schütte A, Layer LL, Ullrich O (2017) Dynamic gene expression response to altered gravity in human T cells. Scientific Reports 7, Article number: 5204.ThielCSHauschildSHugeATauberSLauberBAPolzerJPaulsenKLierHEngelmannFSchmitzBSchütteALayerLLUllrichO2017Dynamic gene expression response to altered gravity in human T cellsScientific Reports7Article number: 520410.1038/s41598-017-05580-x550798128701719Search in Google Scholar
United Nations (2013) Teacher’s Guide to Plant Experiments in Microgravity Human Space Technology Initiative. United Nations Office at ViennaUnitedNations2013Teacher’s Guide to Plant Experiments in MicrogravityHuman Space Technology Initiative. United Nations Office at ViennaSearch in Google Scholar
van Loon JJWA (2016) Centrifuges for microgravity simulation. The Reduced Gravity Paradigm. Frontiers in Astronomy and Space Sciences 3: 21van Loon JJWA2016Centrifuges for microgravity simulation. The Reduced Gravity ParadigmFrontiers in Astronomy and Space Sciences32110.3389/fspas.2016.00021Search in Google Scholar
Uva BM, Masini MA, Sturla M, Tagliafierro G, Strollo F (2002) Microgravity-induced programmed cell death in astrocytes. Journal of Gravitational Physiology 9(1): P275-276UvaBMMasiniMASturlaMTagliafierroGStrolloF2002Microgravity-induced programmed cell death in astrocytesJournal of Gravitational Physiology91P275276Search in Google Scholar
Wagner EB, Charles JB, Cuttino CM (2009) Opportunities for research in space life sciences aboard commercial suborbital flights. Aviation, Space, and Environmental Medicine 80: 984-9861991152510.3357/ASEM.2589.2009WagnerEBCharlesJBCuttinoCM2009Opportunities for research in space life sciences aboard commercial suborbital flightsAviation, Space, and Environmental Medicine80984986Search in Google Scholar
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z, Liu H, Jiang G, Cheng Z, Wang S, Dong J, Feng B, Chard LS, Lemoine NR, Wang Y (2017) Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent. Nature Communications 8(1):13952912308410.1038/s41467-017-01385-8WangPLiXWangJGaoDLiYLiHChuYZhangZLiuHJiangGChengZWangSDongJFengBChardLSLemoineNRWangY2017Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agentNature Communications811395568023429123084Search in Google Scholar
