The use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats

Alaee S, Ilani M. Effect of titanium dioxide nanoparticles on male and female reproductive systems. J Adv Med Sci Appl Technol 3, 3–8, 2017.10.18869/nrip.jamsat.3.1.3Search in Google Scholar

Arora S, Rajwade JM, Paknikar KM. Nanotoxicology and in vitro studies: the need of the hour. Toxicol Appl Pharmacol 258, 151–165, 2012.10.1016/j.taap.2011.11.01022178382Search in Google Scholar

Casalini T, Rossi F, Castrovinci A, Perale G. A perspective on polylactic acid-based polymers use for nanoparticles synthesis and applications. Front Bioeng Biotechnol 7, 259, 2019.10.3389/fbioe.2019.00259679755331681741Search in Google Scholar

Das J, Choi YJ, Song H, Kim JH. Potential toxicity of engineered nanoparticles in mammalian germ cells and developing embryos: Treatment strategies and anticipated applications of nanoparticles in gene delivery. Hum Reprod Update 22, 588–619, 2016.2738535910.1093/humupd/dmw02027385359Search in Google Scholar

Cho H, Gao J, Kwon GS. PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol-gels for drug delivery. J Control Release 240, 191–201, 2016.10.1016/j.jconrel.2015.12.015490959026699425Search in Google Scholar

De Jong WH, Borm PJ. Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine 3, 133–149, 2008.10.2147/IJN.S596Open DOISearch in Google Scholar

Du JZ, Tang LY, Song WJ, Shi Y, Wang J. Evaluation of polymeric micelles from brush polymer with poly(ε-caprolactone)-b-poly(ethyleneglycol) side chains as drug carrier. Biomacromolecules 10, 2169–2174, 2009.10.1021/bm900345m19722555Search in Google Scholar

Dvorakova M, Rollerova E, Scsukova S, Bujnakova Mlynarcikova A, Laubertova L, Zitnanova I. Effect of neonatal exposure to poly(ethylene glycol)-block-poly(lactic acid) nanoparticles on oxidative state in infantile and adult female rats. Oxid Med Cell Longev 2017, 7430435, 2017.10.1155/2017/7430435561088429081892Search in Google Scholar

Ferrandina G, Corrado G, Licameli A, Lorusso D, Fuoco G, Pisconti S, Scambia G. Pegylated liposomal doxorubicin in the management of ovarian cancer. Ther Clin Risk Manag 6, 463–483, 2010.10.2147/TCRM.S3348295248620957139Search in Google Scholar

Gao G, Ze Y, Li B, Zhao X, Zhang T, Sheng L, Hu R, Gui S, Sang X, Sun Q, Cheng J, Cheng Z, Wang L, et al. Ovarian dysfunction and gene-expressed characteristics of female mice caused by long-term exposure to titanium dioxide nanoparticles. J Hazard Mater 243, 19–27, 2012.10.1016/j.jhazmat.2012.08.04923131501Search in Google Scholar

Geraets L, Oomen AG, Krystek P, Jacobsen NR, Wallin H, Laurentie M, Verharen HW, Brandon EF, de Jong WH. Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Part Fibre Toxicol 11, 30, 2014.10.1186/1743-8977-11-30Search in Google Scholar

Grande F, Tucci P. Titanium dioxide nanoparticles: a risk for human health? Mini Rev Med Chem 16, 762–769, 2016.10.2174/1389557516666160321114341Open DOISearch in Google Scholar

Hong FS, Yu XH, Wu N, Zhang YQ. Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles. Toxicol Res 6, 115–133, 2017.10.1039/C6TX00338ASearch in Google Scholar

Hou CC, Zhu JQ. Nanoparticles and female reproductive system: how do nanoparticles affect oogenesis and embryonic development. Oncotarget 8, 109799–109817, 2017.2931265010.18632/oncotarget.19087Search in Google Scholar

Iavicoli I, Leso V, Fontana L, Bergamaschi A. Toxicological effects of titanium dioxide nanoparticles: a review of in vitro mammalian studies. Eur Rev Med Pharmacol Sci 15, 481–508, 2011.21744743Search in Google Scholar

Iavicoli I, Leso V, Bergamaschi A. Toxicological effects of titanium dioxide nanoparticles: a review of in vivo studies. J Nanomater 2012, 964381, 2012.10.1155/2012/964381Search in Google Scholar

Iavicoli I, Fontana L, Leso V, Bergamaschi A. The effects of nanomaterials as endocrine disruptors. Int J Mol Sci 14, 16732–16801, 2013.2394963510.3390/ijms140816732Search in Google Scholar

Kolena J, Scsukova S, Jezova M, Furdova J, Tatara M, Jasem P. Effect of phospholipids on the reconstitution and thermal stability of delipidated rat ovarian luteinizing hormone/human chorionic gonadotropin receptors in proteoliposomes. Mol Cell Endocrinol 113, 53–60, 1995.10.1016/0303-7207(95)03610-JSearch in Google Scholar

Larson JK, Carvan MJ 3rd, Hutz RJ. Engineered nanomaterials: an emerging class of novel endocrine disruptors. Biol Reprod 91, 20, 2014.10.1095/biolreprod.113.116244443496124899576Search in Google Scholar

Moritz M, Gezske-Moritz M. Recent developments in the application of polymeric nanoparticles as drug carriers. Adv Clin Exp Med 24, 749–758, 2015.10.17219/acem/318022676862426768624Open DOISearch in Google Scholar

Newbold RR, Jefferson WN, Padilla-Banks E. Long-term adverse effects of the neonatal exposure to bisphenol A on the murine female reproductive tract. Reprod Toxicol 24, 253–258, 2007.1780419410.1016/j.reprotox.2007.07.006204338017804194Search in Google Scholar

Philbrook NA, Winn LM, Afrooz AR, Saleh NB, Walker VK. The effect of TiO(2) and Ag nanoparticles on reproduction and development of Drosophila melanogaster and CD-1 mice. Toxicol Appl Pharmacol 257, 429–436, 2011.10.1016/j.taap.2011.09.02722005274Search in Google Scholar

Picut CA, Dixon D, Simons ML, Stump DG, Parker GA, Remick AK. Postnatal ovary development in the rat: morphologic study and correlation of morphology to neuroendocrine parameters. Toxicol Pathol 43, 343–353, 2015.2510757410.1177/0192623314544380432098525107574Search in Google Scholar

Rollerova E, Jurcovicova J, Mlynarcikova A, Sadlonova I, Bilanicova D, Wsolova L, Kiss A, Kovriznych J, Kronek J, Ciampor F, Vavra I, Scsukova S. Delayed adverse effects of neonatal exposure to polymeric nanoparticle poly(ethylene glycol)-block-polylactide methyl ether on hypothalamic-pituitary-ovarian axis development and function in Wistar rats. Reprod Toxicol 57, 165–175, 2015a.10.1016/j.reprotox.2015.07.07226193689Search in Google Scholar

Rollerova E, Tulinska J, Liskova A, Kuricova M, Kovriznych J, Mlynarcikova A, Kiss A, Scsukova S. Titanium dioxide nanoparticles: some aspects of toxicity/focus on the development. Endocr Regul 49, 97–112, 2015b.10.4149/endo_2015_02_9725960011Search in Google Scholar

Rompelberg C, Heringa MB, van Donkersgoed G, Drijvers J, Roos A, Westenbrink S, Peters R, van Bemmel G, Brand W, Oomen AG. Oral intake of added titanium dioxide and its nanofraction from food products, food supplements and toothpaste by the Dutch population. Nanotoxicology 10, 1404–1414, 2016.2761900710.1080/17435390.2016.122245727619007Search in Google Scholar

Sebekova K, Dusinska M, Simon Klenovics K, Kollarova R, Boor P, Kebis A, Staruchova M, Vlkova B, Celec P, Hodosy J, Baciak L, Tuskova R, Beno M, Tulinska J, Pribojova J, Bilanicova D, Pojana G, Marcomini A, Volkovova K. Comprehensive assessment of nephrotoxicity of intravenously administered sodium-oleate-coated ultra-small superparamagnetic iron oxide (USPIO) and titanium dioxide (TiO2) nanoparticles in rats. Nanotoxicology 8, 142–157, 2014.10.3109/17435390.2012.76314723272807Search in Google Scholar

Semete B, Booysen L, Lemmer Y, Kalombo L, Katata L, Verschoor J, Swai HS. In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems. Nanomedicine 6, 662–671, 2010.10.1016/j.nano.2010.02.0022023091220230912Open DOISearch in Google Scholar

Shen S, Du XJ, Liu J, Sun R, Zhu YH, Wang J. Delivery of bortezomib with nanoparticles for basal-like triple-negative breast cancer therapy. J Control Release 208, 14–24, 2015.10.1016/j.jconrel.2014.12.04325575864Search in Google Scholar

Shi HB, Magaye R, Castranova V, Zhao JS. Titanium dioxide nanoparticles: A review of current toxicological data. Part Fibre Toxicol 10, 15, 2013.10.1186/1743-8977-10-15363714023587290Search in Google Scholar

Shin HC, Alani AWG, Rao DA, Rockich NC, Kwon GS. Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs. J Control Release 140, 293–300, 2009.10.1016/j.jconrel.2009.04.024278785719409432Search in Google Scholar

Shin HC, Cho H, Lai TC, Kozak KR, Kolesar JM, Kwon GS. Pharmacokinetic study of 3-in-1 poly(ethylene glycol)-block-poly(D,L-lactic acid) micelles carrying paclitaxel, 17-allylamino-17-demethoxygel danamycin, and rapamycin. J Control Release 163, 93–99, 2012.10.1016/j.jconrel.2012.04.024342261222549011Search in Google Scholar

Scsukova S, Mlynarcikova A, Kiss A, Rollerova E. Effect of polymeric nanoparticle poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) on in vitro luteinizing hormone release from anterior pituitary cells of infantile and adult female rats. Neuro Endocrinol Lett 36, 88–94, 2015.26757115Search in Google Scholar

Scsukova S, Bujnakova Mlynarcikvoa A, Kiss A, Rollerova E. Adverse eff ects of polymeric nanoparticle poly(ethylene glycol)- block-polylactide methyl ether (PEG-b-PLA) on steroid hormone secretion by porcine granulosa cells. Endocr Regul 51, 96–104, 2017.10.1515/enr-2017-000928609289Search in Google Scholar

Stefansdottir A, Fowler PA, Powles-Glover N, Anderson RA, Spears N. Use of ovary culture techniques in reproductive toxicology. Reprod Toxicol 49, 117–135, 2014.10.1016/j.reprotox.2014.08.00125150138Search in Google Scholar

Tassinari R, Cubadda F, Moracci G, Aureli F, D’Amato M, Valeri M, De Baerardis B, Raggi A, Mantovani A, Passeri D, Rossi M, Maranghi F. Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen. Nanotoxicology 8, 654–662, 2014.2383434410.3109/17435390.2013.82211423834344Search in Google Scholar

Taylor U, Barchanski A, Kues W, Barcikowski S, Rath D. Impact of metal nanoparticles on germ cell viability and functionality. Reprod Domest Anim 47, 359–368, 2012.10.1111/j.1439-0531.2012.02099.x2282739322827393Open DOISearch in Google Scholar

Wang A, Marinakos SM, Badireddy AR, Powers ChM, Keith AH. Characterization of physicochemical properties of nanomaterials and their immediate environments in high-throughput screening of nanomaterial biological activity, WIREs Nanomed Nanobiotechnol 5, 430–448, 2013.10.1002/wnan.122923661551Search in Google Scholar

Wang N, Wang Z, Nie S, Song L, He T, Yang S, Yang X, Yi C, Wu Q, Gong C. Biodegradable polymeric micelles co-encapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo. Int J Nano-medicine 12, 1499–1514, 2017.10.2147/IJN.S124843532814128260895Open DOISearch in Google Scholar

Weir A, Westerhoff P, Fabricius L, Hristovski K, von Goetz N. Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46, 2242–2250, 2012.10.1021/es204168d328846322260395Open DOISearch in Google Scholar

Xiao RZ, Zeng ZW, Zhou GL, Wang JJ, Li FZ, Wang AM. Recent advances in PEG-PLA block copolymer nanoparticles. Int J Nanomedicine 5, 1057–1065, 2010.10.2147/IJN.S14912300020521170353Search in Google Scholar

Xiao L, Xiong X, Sun X, Zhu Y, Yang H, Chen H, Gan L, Xu H, Yang X. Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles. Biomaterials 32, 5148–5157, 2011.10.1016/j.biomaterials.2011.03.07121546083Open DOISearch in Google Scholar

Zhang X, Li W, Yang Z. Toxicology of nanosized titanium dioxide: an update. Arch Toxicol 89, 2207–2217, 2015.10.1007/s00204-015-1594-626391178Search in Google Scholar

Zhao X, Ze Y, Gao G, Sang X, Li B, Gui S, Sheng L, Sun Q, Cheng J, Cheng Z, Hu R, Wang L, Hong F. Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice. PLoS ONE 8, e59378, 2013.10.1371/journal.pone.0059378361500823565150Search in Google Scholar