2,3-Dihydro-Quinazolin-4(1H)-One as a Fluorescent Sensor for Hg2+ Ion and its Docking Studies in Cancer Treatment
Ghodsi Mohammadi Ziarani
Department of Chemistry, Faculty of Physics and Chemistry, Alzahra UniversityTehran, Iran
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, Shadi Tahmasebi Ashtiani
Department of Chemistry, Faculty of Physics and Chemistry, Alzahra UniversityTehran, Iran
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, Fatemeh Mohajer
Department of Chemistry, Faculty of Physics and Chemistry, Alzahra UniversityTehran, Iran
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, Alireza Badiei
School of Chemistry, College of Science, University of TehranTehran, Iran
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, Sunil V. Gaikwad
Department of Chemistry, Dr. D. Y. Patil ACS Women’s College, Pimpri Pune-411018; Affiliation to Savitribai Phule Pune University, Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University in BratislavaBratislava, Slovakia
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e Rajender S. Varma
Regional Center of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University in OlomoucCzech Republic
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01 feb 2023
INFORMAZIONI SU QUESTO ARTICOLO
Pubblicato online: 01 feb 2023
Pagine: 25 - 33
DOI: https://doi.org/10.2478/cdem-2022-0004
Parole chiave
© 2022 Ghodsi Mohammadi Ziarani et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
The 2,3-dihydro-quinazolin-4(1H)-one was synthesised via the deployment of SBA-Pr-SO3H and its application was explored as a highly selective fluorescent sensor for Hg2+ ion; fluorescence intensity was decreased selectively by Hg2+ ions. Furthermore, this compound also indicated for its superb anti-interference ability among other ions. It is important to mention that this compound could be employed to detect a very low amount of Hg2+ ions, which are highly toxic and general contaminants. The docking study shows that the molecule, 2,3-dihydro-quinazolin-4(1H)-one, is a good inhibitor for the 5ACC enzyme.