[
1. Andreasen P.A., Kjoller L., Christensen L., Duffy M.J.: The urokinase type plasminogen activator system in cancer metastasis: a review. Int J Cancer 1997, 72, 1-22.10.1002/(SICI)1097-0215(19970703)72:1<1::AID-IJC1>3.0.CO;2-Z
]Search in Google Scholar
[
2. Angenete E., Langenskiöld M., Palmgren I., Falk P., Öresland T., Ivarsson M.L.: uPA and PAI-1 in rectal cancer - relationship to radiotherapy and clinical outcome. J Surg Res 2009, 153, 46-53.10.1016/j.jss.2008.02.043
]Search in Google Scholar
[
3. Bailey T.R., Paulsen D.B., Sehgal I., Hosgood G.: Immunohistochemical staining of urokinase plasminogen activator-like and urokinase plasminogen activator receptor-like proteins in the urinary tract of healthy dogs. Am J Vet Res 2006, 67, 1628-1634.10.2460/ajvr.67.9.1628
]Search in Google Scholar
[
4. Borgfeldt C., Casslen B., Liu C.L., Hansson S., Lecander I., Astedt B.: High tissue content of urokinase plasminogen activator (u-PA) is associated with high stromal expression of uPA mRNA in poorly differentiated serous ovarian carcinoma. Int J Cancer 1998, 79, 588-595.10.1002/(SICI)1097-0215(19981218)79:6<588::AID-IJC6>3.0.CO;2-W
]Search in Google Scholar
[
5. Blasi F., Carmeliet P.: uPAR: a versatile signaling orchestrator. Nat Rev Mol Cell Biol 2002, 3, 932-943.10.1038/nrm977
]Search in Google Scholar
[
6. Buo L., Meling G.I., Karlsrud T.S., Johansen H.T., Aasen A.O.: Antigen levels of urokinase plasminogen activator and its receptor at the tumour-host interface of colorectal adenocarcinomas are related to tumour aggressiveness. Hum Path 1995, 26, 1133-1138.10.1016/0046-8177(95)90276-7
]Search in Google Scholar
[
7. Carmeliet P., Jain R.K.: Angiogenesis in cancer and other diseases. Nature 2000, 407, 249-257.10.1038/35025220
]Search in Google Scholar
[
8. Carmeliet P., Schoonjans L., Kieckens L., Ream B., Degen J., Bronson R., De Vos R., van den Oord J.J., Collen D., Mulligan R.C.: Physiological consequences of loss of plasminogen activator gene function in mice. Nature 1994, 368, 419-424.10.1038/368419a0
]Search in Google Scholar
[
9. Damjanovich L., Turzo C., Adany R.: Factors involved in the plasminogen activation system in human breast tumours.Thromb Haemost 1994, 71, 684-691.10.1055/s-0038-1642505
]Search in Google Scholar
[
10. Dublin E., Hanby A., Patel N.K., Liebman R., Barnes D.: Immunohistochemical expression of uPA, uPAR, and PAI-1 in breast carcinoma. Fibroblastic expression has strong associations with tumour pathology. Am J Pathol 2000, 157, 1219-1227.10.1016/S0002-9440(10)64637-8
]Search in Google Scholar
[
11. Duffy M.J., Duggan C.: The urokinase plasminogen activator system: a rich source of tumour markers for the individualized management of patients with cancer. Clin Biochem 2004, 37, 541-548.10.1016/j.clinbiochem.2004.05.013
]Search in Google Scholar
[
12. Elston C.W., Ellis I.O.: Assessment of histological grade. In: Systemic Pathology - The Breast, edited by C.W. Elston and I.O. Ellis, Churchill and Livingstone, London, 1998, pp. 365-384.
]Search in Google Scholar
[
13. Guo Y., Higazi A.A.R., Arakelian A., Sachais B.S., Cines D., Goldfarb R.H., Jones T.R., Kwaan H., Mazar A.P., Rabbani S.A.: A peptide derived from the non receptor binding region of urokinase plasminogen activator (uPA) inhibits tumour progression and angiogenesis and induces tumour cell death invivo. FASEB J 2000, 14, 1400-1410.10.1096/fasebj.14.10.1400
]Search in Google Scholar
[
14. Han B., Nakamura M., Zhou G., Ishii A., Nakamura A., Bai Y., Mori I., Kakudo K.: Calcitonin inhibits invasion of breast cancer cells: involvement of urokinase-type plasminogen activator (uPA) and uPA receptor. Int J Oncol 2006, 28, 807-814.10.3892/ijo.28.4.807
]Search in Google Scholar
[
15. Han B., Nakamura M., Mori I., Nakamura Y., Kakudo K.: Urokinase-type plasminogen activator system and breast cancer. Oncol Rep 2005, 14, 105-112.
]Search in Google Scholar
[
16. Harbeck N., Kates R.E., Schmitt M., Gauger K., Kiechle M., Janicke F.: Urokinase-type plasminogen activator and its inhibitor type 1 predict disease outcome and therapy response in primary breast cancer. Clin Breast Canc 2004, 5, 348-352.10.3816/CBC.2004.n.040
]Search in Google Scholar
[
17. Hildenbrand R., Schaaf A., Dorn-Beineke A., Allgayer H., Sütterlin M., Marx A., Stroebel P.: Tumour stroma is the predominant uPA, uPAR, PAI-1expressing tissue in human breast cancer: prognostic impact. Histol Histopathol 2009, 24, 869-877.
]Search in Google Scholar
[
18. Hundsdorfer B., Zeilhofer H.F., Bock K.P., Dettmar P., Schmitt M., Kolki A., Pautke C., Horch H.H.: Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity - clinical relevance and prognostic value. J Cranio Maxill Surg 2005, 33, 191-196.10.1016/j.jcms.2004.12.005
]Search in Google Scholar
[
19. Liotta L.A., Steeg P.S., Stetler-Stevenson W.G.: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991, 64, 327-336.10.1016/0092-8674(91)90642-C
]Search in Google Scholar
[
20. Look M.P., van Putten W.L., Duffy M.J., Harbeck N., Christensen I.J., Thomssen C., Kates R., Spyratos F., Fernö M., Eppenberger-Castori S., Sweep C.G., Ulm K., Peyrat J.P., Martin P.M., Magdelenat H., Brünner N., Duggan C., Lisboa B.W., Bendahl P.O., Quillien V., Daver A., Ricolleau G., Meijervan Gelder M.E., Manders P., Fiets W.E., Blankenstein M.A., Broët P., Romain S., Daxenbichler G., Windbichler G., Cufer T., Borstnar S., Kueng W., Beex L.V., Klijn J.G., O'Higgins N., Eppenberger U., Jänicke F., Schmitt M., Foekens J.A.: Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients. J Natl Cancer Inst 2002, 94, 116-128.
]Search in Google Scholar
[
21. Misdorp W., Else R.W., Hellmen E., Lipscomb T.P.: Histological classification of the mammary tumours of the dog and the cat. In: World Health Organization InternationalHistological Classification of Tumours of Domestic Animals, edited by F.I. Shulman, Armed Forces Institute of Pathology, Washington DC, 1999, pp. 16-29
]Search in Google Scholar
[
22. Nielsen B.S., Rank F., Illemann M., Lund L.R., Danø K.: Stromal cells associated with early invasive foci in human mammary ductal carcinoma in situ coexpress urokinase and urokinase receptor. Int J Cancer 2007, 120, 2086-2095.10.1002/ijc.2234017290405
]Search in Google Scholar
[
23. Nielsen B.S., Sehested M., Duun S., Rank F., Timshel S., Rygaard J., Johnsen M., Danø, K.: Urokinase plasminogen activator is localized in stromal cells in ductal breast cancer. Lab Invest 2001, 81, 1485-1501.10.1038/labinvest.378036311706057
]Search in Google Scholar
[
24. Reuning U., Magdolen V., Hapke S., Schmitt M.: Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins. Biol Chem 2003, 384, 1119-1131.10.1515/BC.2003.12512974381
]Search in Google Scholar
[
25. Santos A.A., Lopes C.C., Ribeiro J.R., Martins L.R., Santos J.C., Amorim I.F., Gärtner F., Matos A.J.: Identification of prognostic factors in canine mammary malignant tumours: a multivariable survival study. BMC Vet Res 2013, 9, doi: 10.1186/1746-6148-9-1.10.1186/1746-6148-9-1354231223289974
]Search in Google Scholar
[
26. Santos A., Lopes C., Marques R.M., Amorim I., Ribeiro J., Frias C., Vicente C., Gärtner F., Matos A.: Immunohistochemical analysis of urokinase plasminogen activator and its prognostic value in canine mammary tumours. Vet J 2011, 189, 43-48.10.1016/j.tvjl.2010.05.023
]Search in Google Scholar
[
27. Schmitt M., Wilhelm O.G., Reuning U., Krüger A., Harbeck N., Lengyel E., Graeff H., Gänsbacher B., Kessler H., Bürgle M., Stürzebecher J., Sperl S., Magdolen V.: The urokinase plasminogen activation system as a novel target for tumour therapy. Fibrinolysis Proteol 2000, 14, 114-132.10.1054/fipr.2000.0079
]Search in Google Scholar
[
28. Schneider J., Pollan M., Tejerina A., Sanchez J., Lucas A.R.: Accumulation of uPA-PAI-1 complexes inside the tumour cells is associated with axillary nodal invasion in progesterone- receptor-positive early breast cancer. Br J Cancer 2003, 88, 96-101.10.1038/sj.bjc.6600656
]Search in Google Scholar
[
29. Ulisse S., Baldini E., Sorrenti S., D’Armiento M.: The urokinase plasminogen activator system: a target for anti-cancer therapy. Curr Cancer Drug Targ 2009, 9, 32-71.10.2174/156800909787314002
]Search in Google Scholar
[
30. Wang Y.: The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis. Med Res Rev 2001, 21, 146-170. 10.1002/1098-1128(200103)21:2<146::AID-MED1004>3.0.CO;2-B
]Search in Google Scholar