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Influence of potential gene polymorphisms on propofol dosage regimen in patients undergoing abdominal hysterectomy

E Ivanov
E Ivanov
, 
Z Sterjev
Z Sterjev
, 
I Budic
I Budic
, 
J Nojkov
J Nojkov
, 
D Karadzova
D Karadzova
 e 
A Sivevski
A Sivevski
   | 23 mar 2021
Balkan Journal of Medical Genetics's Cover Image
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Article Category: Original article
Pubblicato online: 23 mar 2021
Pagine: 41 - 48
DOI: https://doi.org/10.2478/bjmg-2020-0030
Parole chiave
© 2020 Ivanov E, Sterjev Z, Budic I, Nojkov J, Karadzova D, Sivevski A, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Correlation of the CYP2B6 (c.516G>A) genotype and times for anesthesia induction (A) and awakening (B).
Correlation of the CYP2B6 (c.516G>A) genotype and times for anesthesia induction (A) and awakening (B).

Figure 2

Correlation of the GABRA A (c.1059+15G>A) genotype and times for anesthesia induction (A) and awakening (B).
Correlation of the GABRA A (c.1059+15G>A) genotype and times for anesthesia induction (A) and awakening (B).

Figure 3

Correlation of the ABCB1 (c.3435T>C) genotype and times for anesthesia induction (A) and awakening (B).
Correlation of the ABCB1 (c.3435T>C) genotype and times for anesthesia induction (A) and awakening (B).

Correlation of polymorphisms in the CYP2B6, GABRA1 and ABCB1 genes and doses of propofol used for the introduction and additional doses during anesthesia.

GenesCYP2B6 (c.516G>T)GABRA1 (c.1059+15G>A)ABCB1 (c.3435T>C)
Alleles (n)GG (53)GA (32)AA (5)p ValueGG (34)AG (38)AA (18)p ValueTT (23)CC (22)CT (45)p Value
Introduction to anesthesia: Propofol (mg)
Mean±SD144.7± 40.9141.0± 39.9133.9± 40.70.80140.6± 40.2138.9± 42.0143.2± 37.10.45132.0± 47.0152.2± 38.2146.7± 42.50.56
Additional dose: Propofol (mg)
Mean±SD129.3± 43.6145.0± 52.3126.7± 47.50.46146.7± 51.6122.4± 40.3130.0± 48.30.4112.3± 68.1144.4± 52.7140.4± 48.30.57

The most common side effects of Propofol in correlation with different genotypes.

GenesCYP2B6 (c.516G>T)GABRA1 (c.1059+15G>A)ABCB1 (c.3435T>C)
Alleles (n)GG (53)GT (32)TT (5)p ValueGG (34)AG (38)AA (18)p ValueTT (23)CC (22)CT (45)p Value
Nausean (%)n (%)n (%)n (%)n (%)n (%)n (%)n (%)n (%)
score 051 (96.22)30 (93.74)5 (100.0)0.7432 (94.12)36 (94.74)18 (100.0)0.5423 (100.0)21 (95.45)42 (93.33)0.52
score 11 (1.89)0 (0.0)0 (0.0)0 (0.0)1 (2.63)0 (0.0)0 (0.0)1 (4.55)0 (0.0)
score 21 (1.89)1 (3.13)0 (0.0)2 (5.88)0 (0.0)0 (0.0)0 (0.0)0 (0.0)2 (4.44)
score 30 (0.0)1 (3.13)0 (0.0)0 (0.0)1 (2.63)0 (0.0)0 (0.0)0 (0.0)1 (2.22)
Vomiting
#052 (98.11)30 (93.74)5 (100.0)0.5532 (94.12)37 (97.37)18 (100.0)0.3323 (100.0)22 (100.0)42 (93.33)0.75
#11 (1.89)1 (3.13)0 (0.0)2 (5.88)0 (0.0)0 (0.0)0 (0.0)0 (0.0)2 (4.44)
#20 (0.0)1 (3.13)0 (0.0)0 (0.0)1 (2.63)0 (0.0)0 (0.0)0 (0.0)1 (2.22)
Sedation
score 046 (86.79)32 (100.0)5 (100.0)0.6931 (91.18)34 (89.47)18 (100.0)0.9621 (91.30)21 (95.45)41 (91.11)0.88
score 11 (1.89)0 (0.0)0 (0.0)0 (0.0)1 (2.63)0 (0.0)0 (0.0)0 (0.0)1 (2.22)
score 23 (5.66)0 (0.0)0 (0.0)2 (5.88)1 (2.63)0 (0.0)1 (4.350 (0.0)2 (4.44)
score 32 (3.77)0 (0.0)0 (0.0)1 (2.94)1 (2.63)0 (0.0)1 (4.35)1 (4.55)0 (0.0)
score41 (1.89)0 (0.0)0 (0.0)0 (0.0)1 (2.63)0 (0.0)0 (0.0)0 (0.0)1 (2.22)

Distribution of the polymorphisms of the examined genes in patients.

CYP2B6(c.516G>T)GABRA1(c.1059+15G>A)ABCB1(c.3435T>C)
GGGTTTGGAGAACCCTTT
0.590.360.050.380.420.200.240.500.26
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