ETHNIC VARIATION IN INTERLEUKIN-6 –174 (G/C) POLYMORPHISM IN THE MALAYSIAN POPULATION

1. Hong DS, Angelo LS, Kurzrock R. Interleukin-6 and its receptor in cancer: implication for translational therapeutic. Cancer. 2007; 110(9): 1911-1928.10.1002/cncr.22999Search in Google Scholar

2. Chung YC, Chaen YL, Hsu CP. Clinical significance of tissue expression of interleukin-6 in colorectal carcinoma. Anti-Cancer Res. 2006; 26(5B): 3905-1911.Search in Google Scholar

3. Jenny NS, Tracy RP, Ogg MS, Lung Le A, Kuller LH, et al. In the elderly, interleukin-6 plasma levels and the -174G>C polymorphisms are associated with the development of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2002; 22(12): 2066-2071.10.1161/01.ATV.0000040224.49362.60Search in Google Scholar

4. Gangwar R, Mittal B, Mittal RD. Association with interleukin-6 -174G>C promoter polymorphism with risk of cervical cancer. Int J Biol Marker. 2009; 24(1): 11-16.10.1177/172460080902400102Search in Google Scholar

5. Pola R, Flex A, Gaetani E, Lago AD, Geradino L, Pola P, et al. The -174 polymorphism of the interleukin-6 gene is associated with Alzheimer’s disease in an Italian population. Neuroreport. 2002; 13(13): 1645-1647.10.1097/00001756-200209160-00015Search in Google Scholar

6. Kishimoto T. Interleukin-6: from basic science to medicine - 40 years in immunology. Annu Rev Immunol. 2005; 23: 1-21.10.1146/annurev.immunol.23.021704.115806Search in Google Scholar

7. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, et al. The effect of novel poly-morphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 1998; 102(7): 1369-1376.10.1172/JCI2629Search in Google Scholar

8. Ikeda U, Ikeda M, Oohara T, Ooguchi A, Kamitani T, Tsuruya Y, et al. Interleukin-6 stimulates growth of vascular smooth muscle in a PDGFdependent manner. Am J Physiol. 1991; 260(5 Pt 2): H1713-H1717.10.1152/ajpheart.1991.260.5.H1713Search in Google Scholar

9. Meenagh A, Fionnuala W, Owen AR, Patterson C, Gorodezsky C, Hammond M, et al. Frequency of cytokine polymorphism in populations from Western Europe, Africa, Asia, the Middle East and South America. Hum Immunol. 2002; 63(11): 1055-1061.10.1016/S0198-8859(02)00440-8Search in Google Scholar

10. Poli F, Nocco A, Berra S, Scalamogna M, Taioli E, Longhi E, et al. Allele frequencies of TNF-a, IL-6, IL-10 and IFN-g in an Italian Caucasian population. Eur J Immunogenet. 2002; 29(3): 237-240.10.1046/j.1365-2370.2002.00303.x12047360Search in Google Scholar

11. Kesarwani P, Ahirwar D, Singh R, Manchanda PL, Mittal RD. Do IL-4 intron 3 VNTR and IL-6 (-174) G/C variants reflect ethnic variation? A comparative study between the global and North Indian populations. Asian Pac J Cancer Prev. 2008; 9(1):76-80.Search in Google Scholar

12. Ognjanovic S, Yamamoto J, Saltzman B, Franke A, Ognjanovic M, Yokochi L, et al. Serum CRP and IL-6, genetic variants and colorectal adenoma in a multiethnic population. Cancer Causes Control. 2010; 21(7): 1131-1138.10.1007/s10552-010-9540-720333461Search in Google Scholar

13. Riikola A, Sipilä K, Kähonen M, Jula A, Nieminen MS, Moilanen L, et al. Interleukin-6 promoter polymorphism and cardiovascular risk factors: the Health Survey 2000. Atherosclerosis. 2007; 207(2): 466-470.10.1016/j.atherosclerosis.2009.06.004Search in Google Scholar

14. Capurso C, Solfrizzi V, D’Introno A, Colacicco AM, Capurso SA, Capurso A, et al. Interleukin-6 -174 G/C promoter gene polymorphism and sporadic Alzheimer disease: geographic allele and genotypic variation in Europe. Exp Gerontol. 2004; 39(10): 1567-1573.10.1016/j.exger.2004.07.006Search in Google Scholar

15. Donn RP, Barret JH, Farhan A, Stopford A, Pepper L, Shelley E, et al. Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group. Arthritis Rheum. 2001; 44(4): 802-810.10.1002/1529-0131(200104)44:4<802::AID-ANR136>3.0.CO;2-GSearch in Google Scholar

16. Pan M, Gao SP, Jiang MH, Gua J, Zheng JG, Zhu JH. Interluekin-6 promoter polymorphism in normal Han Chinese population: frequency and effects on inflammatory markers. J Invest Med. 2011;59(2):272-276.10.2310/JIM.0b013e318206ffadSearch in Google Scholar

17. Hirschman C. The meaning and measurement of ethnicity in Malaysia: an analysis of census classification. J Asian Stud. 1987; 46(3): 555-582.10.2307/2056899Search in Google Scholar

18. Chua KH, Kee BP, Tan SY, Lian LH. Interleukin-6 promoter polymorphisms (-174G/C) in Malaysian patients with systemic lupus erythematosus. Braz J Med Biol Res. 2009; 42(6): 551-555.10.1590/S0100-879X2009000600012Search in Google Scholar

19. Tong Y, Lu Z, Zhang Y, Ye J, Zhan F, Hou S, etal. Comparison of the G-174C polymorphism of interleu-kin (IL)-6 in different countries. African J Biotechnol. 2012; 11(28): 7166-769.Search in Google Scholar

20. Park BL, Lee HS, Kim YJ, Kim JY, Jung JH, Kim LH, et al. Association between interleukin 6 promoter variation and chronic hepatitis B progression. Exp Mol Med. 2003; 35(2): 76-82.10.1038/emm.2003.11Search in Google Scholar

21. Visentainer JEL, Sell AM, da Silva GC, Cavichioli ADG, Franceschi DSA, Liebert SR, etal. TNF, IFNG, IL-6, IL-10 and TGFB1 gene polymorphisms in South and Southeast Brazil. Int J Immunogenet. 2008; 35(4-5): 287-293.10.1111/j.1744-313X.2008.00778.xSearch in Google Scholar

22. Ryu JH, Kim SJ. Interleukin-6 -634C/G and -174 G/C polymorphisms in Korean patients undergoing hemodialysis. Korean J Int Med. 2012; 27(3): 327-337.10.3904/kjim.2012.27.3.327Search in Google Scholar

23. Pyo CW, Hur SS, Kim YK, Choi HB, Hong YS, Kim DW, et al. Polymorphism of IL-1B, IL-1 RN, IL-2, IL-4, IL-6, IL-10 and IFN-g genes in the Korean population. Hum Immunol. 2003; 64(10): 979-989.10.1016/S0198-8859(03)00173-3Search in Google Scholar

24. Bhanoori M, Babu KA, Deenadayal M, Kennedy S, Shivaji S.. The interleukin-6 -174G/C promoter polymorphism is not associated with endometriosis in South Indian women. J Soc Gynecol Investig. 2005; 12(5): 365-369.10.1016/j.jsgi.2005.03.00515979549Search in Google Scholar

25. Liu RY, Song X, Chen P, Lei Z, Miao J, Yi N, et al. Association between IL 6 -174G/C and cancer; a meta-analysis of 105,482 individuals. Exp Ther Med. 2012; 3(4): 655-664.10.3892/etm.2012.454343870322969947Search in Google Scholar

26. Xu B, Niu XB, Wang ZD, Cheng W, Tong N, Mi YY, et al. IL-6 -174G>C polymorphism and cancer risk: a meta-analysis involving 29,377 cases and 37,739 controls. Mol Bio. Rep. 2011; 38(4): 2589-2596.Search in Google Scholar

27. Yin YW, Hu AM, Sun QQ, Liu HL, Wong Q, Zeng YH, et al. Associations between IL-6 gene -174G/C polymorphism and the risk of coronary heart disease; a meta-analysis of 20 studies including 9619 cases and 10,919 controls. Gene. 2012; 53(1): 25-30.10.1016/j.gene.2012.04.07522575724Search in Google Scholar

28. Lee J, Heng D, Chia KS, Chew SK, Tan BY, Hughes K. Risk factors and incidence of coronary artery disease in Chinese, Malay and Asian Indians males: the Singapore Cardiovascular Cohort Study. Int J Epidemiol. 2001; 30(5): 983-988.10.1093/ije/30.5.98311689508Search in Google Scholar

29. Heng DM, Lee J, Chew SK, Tan BY, Hughes K, Chia KS. Incidence of ischaemic heart disease and stroke in Chinese, Malays and Indians in Singapore: Singapore cardiovascular cohort study. Ann Acad Med Singapore. 2000; 29(2): 231-236.Search in Google Scholar

30. Amin AA, Nathan S, Evans AT, Attanasio S, Mukhopadhyay E, Metha V, et al. The effect of ethnicity on the relationship between premature coronary artery disease and traditional cardiac risk factors among uninsured young adults. Prev Cardiol. 2009; 12(3): 128-135. 10.1111/j.1751-7141.2009.00025.x19534020Search in Google Scholar