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<p>This interview delves into the relationship between zinc (Zn) and copper (Cu) in autism spectrum disorder (ASD), featuring insights from Dr. Geir Bjørklund, MD, a Norwegian researcher. Collaborative studies conducted across diverse countries, including China, Slovenia, Romania, Russia, Brazil, and Egypt, consistently reveal altered Zn and Cu levels in individuals with ASD. These findings suggest a potential correlation between elevated Cu levels and increased severity of ASD symptoms. Dr. Bjørklund emphasizes the multifaceted dynamics of metallothioneins (MTs), essential proteins for metal binding and detoxification, and their potential association with Zn deficiency in ASD individuals. The interview illuminates the balance between Zn and Cu within the GABAergic system, implicating these trace elements in synaptic modulation and broader neurobiological functions. Future research directions proposed by Dr. Bjørklund encompass exploring multiple biological mediums for accurate trace element assessment, investigating interactions between different trace elements, and exploring factors influencing trace element levels in various tissues. The significance of Zn supplementation in treating ASD, the implications of MT dysfunction, and the importance of dual monitoring of Cu and Zn during therapy are thoroughly discussed. The conclusion expresses gratitude for Dr. Bjørklund’s invaluable contributions to comprehending the role of Zn and Cu in ASD, highlighting the global relevance of his research and the need for a comprehensive approach to understanding trace element dynamics in this complex neurodevelopmental disorder.</p>
</abstract>

This interview delves into the relationship between zinc (Zn) and copper (Cu) in autism spectrum disorder (ASD), featuring insights from Dr. Geir Bjørklund, MD, a Norwegian researcher. Collaborative studies conducted across diverse countries, including China, Slovenia, Romania, Russia, Brazil, and Egypt, consistently reveal altered Zn and Cu levels in individuals with ASD. These findings suggest a potential correlation between elevated Cu levels and increased severity of ASD symptoms. Dr. Bjørklund emphasizes the multifaceted dynamics of metallothioneins (MTs), essential proteins for metal binding and detoxification, and their potential association with Zn deficiency in ASD individuals. The interview illuminates the balance between Zn and Cu within the GABAergic system, implicating these trace elements in synaptic modulation and broader neurobiological functions. Future research directions proposed by Dr. Bjørklund encompass exploring multiple biological mediums for accurate trace element assessment, investigating interactions between different trace elements, and exploring factors influencing trace element levels in various tissues. The significance of Zn supplementation in treating ASD, the implications of MT dysfunction, and the importance of dual monitoring of Cu and Zn during therapy are thoroughly discussed. The conclusion expresses gratitude for Dr. Bjørklund’s invaluable contributions to comprehending the role of Zn and Cu in ASD, highlighting the global relevance of his research and the need for a comprehensive approach to understanding trace element dynamics in this complex neurodevelopmental disorder.

The Zinc-Copper Connection In Autism Spectrum Disorder: Pioneering Work Of Dr. Geir Bjørklund

ARS Medica Tomitana

This work is licensed under the Creative Commons Attribution 4.0 International License.

This interview delves into the relationship between zinc (Zn) and copper (Cu) in autism spectrum disorder (ASD), featuring insights from Dr. Geir Bjørklund,...

The Zinc-Copper Connection In Autism Spectrum Disorder: Pioneering Work Of Dr. Geir Bjørklund

Pubblicato online: 23 apr 2024

Pagine: 245 - 257

DOI: https://doi.org/10.2478/arsm-2023-0036

Parole chiave
autism, zinc, copper, metallothioneins, GABAergic system, trace elements

© 2023 Yuliya Semenova, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The Zinc-Copper Connection In Autism Spectrum Disorder: Pioneering Work Of Dr. Geir Bjørklund

Pubblicato online: 23 apr 2024

Pagine: 245 - 257

DOI: https://doi.org/10.2478/arsm-2023-0036

Parole chiaveautism, zinc, copper, metallothioneins, GABAergic system, trace elements

© 2023 Yuliya Semenova, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Parole chiave
autism, zinc, copper, metallothioneins, GABAergic system, trace elements