<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Allelic and haplotypic variations at 27 SNP sites identified in four CpG islands of OAS1 were described in a group of Anglo-Arabian and Hucul horses. Variation in the type of less frequent alleles was the source of variability among breeds. A number of putative LD blocks were identified which could be used to study changes in the genetic structure between generations of both breeds concerning susceptibility to flaviviral infections. Some of the identified SNPs may have an impact on the transcriptional activity of OAS1 or could lead to amino acid substitution influencing proper function of OAS1 enzyme. In the light of recent studies, the described genetic variability of investigated CpG islands might be important in view of the effectiveness of viral incorporation into the host genome.</p></abstract>

Allelic and haplotypic variations at 27 SNP sites identified in four CpG islands of OAS1 were described in a group of Anglo-Arabian and Hucul horses. Variation in the type of less frequent alleles was the source of variability among breeds. A number of putative LD blocks were identified which could be used to study changes in the genetic structure between generations of both breeds concerning susceptibility to flaviviral infections. Some of the identified SNPs may have an impact on the transcriptional activity of OAS1 or could lead to amino acid substitution influencing proper function of OAS1 enzyme. In the light of recent studies, the described genetic variability of investigated CpG islands might be important in view of the effectiveness of viral incorporation into the host genome.

Genetic Variation of Two Horse Breeds in Cpg Islands of Oas1 Locus

Laboratory of Genomics, National Research Institute of Animal Production, 32-083 Balice n. Kraków, Poland

Department of Cytogenetics and Molecular Genetics, National Research Institute of Animal Production, 32-083 Balice n. Kraków, Poland

Annals of Animal Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Genetic Variation of Two Horse Breeds in Cpg Islands of Oas1 Locus"}

Allelic and haplotypic variations at 27 SNP sites identified in four CpG islands of OAS1 were described in a group of Anglo-Arabian and Hucul horses. Variation...

Genetic Variation of Two Horse Breeds in Cpg Islands of Oas1 Locus

Pubblicato online: 15 nov 2014

Pagine: 841 - 850

Ricevuto: 30 gen 2014

Accettato: 01 ago 2014

DOI: https://doi.org/10.2478/aoas-2014-0069

Parole chiave
OAS1, genetic variation, CpG islands, horses

© by Tomasz Ząbek

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Genetic Variation of Two Horse Breeds in Cpg Islands of Oas1 Locus

Pubblicato online: 15 nov 2014

Pagine: 841 - 850

Ricevuto: 30 gen 2014

Accettato: 01 ago 2014

DOI: https://doi.org/10.2478/aoas-2014-0069

Parole chiaveOAS1, genetic variation, CpG islands, horses

© by Tomasz Ząbek

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
OAS1, genetic variation, CpG islands, horses