Development of semisolid pharmaceutical forms with mometasone furoate
Pubblicato online: 28 dic 2023
Pagine: 280 - 284
Ricevuto: 21 ott 2023
Accettato: 06 nov 2023
DOI: https://doi.org/10.2478/amma-2023-0045
Parole chiave
© 2023 Emőke Margit Rédai et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Objective
This study aims to develop semisolid pharmaceutical forms for the topical administration of mometasone furoate.
Methods
Two creams (O1 and O2) and four hydroxypropyl methylcellulose-based hydrogels were prepared (H3-H6). Two different sorts of hydroxypropyl methylcellulose were used in concentrations of 15 and 20%. Consistency, spreadability, viscosity, and pH were measured. In vitro drug release was determined by a vertical, Franz diffusion cell. Mathematical models were applied for a better understanding of release phenomena.
Results
O1 and O2 presented lower values for penetration depth and spreadability. Hydrogel viscosity is influenced by the type and concentration of the gel-forming agent. Viscosity decreases in the order H6, H5, H4, and H3. pH varies between 4.6 to 5.92, fulfilling the requirements of European Pharmacopiea. Creams showed 5.49 and 6.59% of mometasone released after 6 hours. The lowest viscosity hydrogel presented the best dissolution of 40.11% mometasone after 6 hours.
Conclusions
H3 hydrogel releases the highest amount of mometasone furoate after 6 hours. The release is best described by the Korsmeyer-Peppas model explained by water diffusion and polymeric chain relaxation happen during the swelling of the polymer.