Recent progress in apoptosis triggering facilitated by HeLa Studies

1 Frattini A, Fabbri M, Valli R, et.al. High variability of genomic instability and gene expression profiling in different HeLa clones. Sci Rep. 2015, 5: 15377 Search in Google Scholar

2 Abid F, Saleem M, Muller CD, et.al. Anti-Proliferative and ApoptosisInducing Activity of Acacia Modesta and Opuntia Monocantha Extracts on HeLa Cells. Asian Pac J Cancer Prev. 2020, 21(10): 3125-3131 Search in Google Scholar

3 Al-Oqail MM, Farshori NN, Al-Sheddi ES, et.al. Oxidative Stress Mediated Cytotoxicity, Cell Cycle Arrest, and Apoptosis Induced by Rosa damascena in Human Cervical Cancer HeLa Cells. Oxid Med Cell Longev. 2021, 2021: 6695634. Search in Google Scholar

4 Meng X, Dang T, Chai J. From Apoptosis to Necroptosis: The Death Wishes to Cancer. Cancer Control. 2021, 28: 10732748211066311. Search in Google Scholar

5 Poondla N, Chandrasekaran AP, Heese K, Kim KS, Ramakrishna S. CRISPR-mediated upregulation of DR5 and downregulation of cFLIP synergistically sensitize HeLa cells to TRAIL-mediated apoptosis. Biochem Biophys Res Commun. 2019, 512(1): 60-65. Search in Google Scholar

6 Kumar, V., Abbas, A. K., & Aster, J. C., Robbins and Cotran pathologic basis of disease (Ninth edition.). Calisto, PA: Elsevier/Saunders. 2015, pp. 6-16 Search in Google Scholar

7 Fathy M, Fawzy MA, Hintzsche H, Nikaido T, Dandekar T, Othman EM. Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation. Molecules. 2019, 24(21): 3979. Search in Google Scholar

8 Pawar JS, Mustafa S, Ghosh I. Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells. Saudi J Biol Sci. 2022, 29(5): 3838-3847 Search in Google Scholar

9 Zhang Y, Yuan F, Li P et.al. Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function. Ecotoxicol Environ Saf. 2022, 241: 113788. Search in Google Scholar

10 Zeng Z, Cai J, Li Fet, et.al. Synthesis, crystal structures, DNA interactions, and antitumor activity of two new dinuclear copper(ii) complexes with thiazole ligand. RSC Adv. 2021, 11(63): 40040-40050 Search in Google Scholar

11 Álvarez-Ortiz P, Ascacio-Valdés J, Vera-Reyes I, et.al. Purshia plicata Triggers and Regulates Proteins Related to Apoptosis in HeLa Cancer Cells. Plants (Basel). 2021, 10(12): pii: 2559 Search in Google Scholar

12 Ortega-Forte E, Rovira A, Gandioso A, et.al. COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents. J Med Chem. 2021, 64(23): 17209-17220. Search in Google Scholar

13 Pandey S, Sharma VK, Biswas A, Lahiri M, Basu S. Small moleculemediated induction of endoplasmic reticulum stress in cancer cells. RSC Med Chem. 2021, 12(9): 1604-1611 Search in Google Scholar

14 Xiong C, Li P, Luo Q, et.al. Induction of Apoptosis in HeLa Cells by a Novel Peptide from Fruiting Bodies of Morchella importuna via the Mitochondrial Apoptotic Pathway. Evid Based Complement Alternat Med. 2021, 2021: 5563367 Search in Google Scholar

15 Xu G, Yan X, Hu Z, et.al. Glucocappasalin Induces G2/M-Phase Arrest, Apoptosis, and Autophagy Pathways by Targeting CDK1 and PLK1 in Cervical Carcinoma Cells. Front Pharmacol. 2021, 12:671138. Search in Google Scholar

16 Raina R, Pramodh S, Rais N, et.al. Luteolin inhibits proliferation, triggers apoptosis and modulates Akt/mTOR and MAP kinase pathways in HeLa cells. Oncol Lett. 2021, 21(3): 192. Search in Google Scholar

17 Xu L, Wang J, Yuan X, et.al. IU1 suppresses proliferation of cervical cancer cells through MDM2 degradation. Int J Biol Sci. 2020, 16(15): 2951-2963. Search in Google Scholar

18 Chandrasekaran AP, Poondla N, Ko NR, Oh SJ, Ramakrishna S. YM155 sensitizes HeLa cells to TRAIL-mediated apoptosis via cFLIP and survivin downregulation. Oncol Lett. 2020, 20(4): 72. Search in Google Scholar

19 Zhou M, Peng BR, Tian W, et.al. 12-Deacetyl-12-epi-Scalaradial, a Scalarane Sesterterpenoid from a Marine Sponge Hippospongia sp., Induces HeLa Cells Apoptosis via MAPK/ERK Pathway and Modulates Nuclear Receptor Nur77. Mar Drugs. 2020, 18(7). Search in Google Scholar

20 Lin R, Hu X, Chen S, Shi Q, Chen H. Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits β-catenin pathway and arrests cell cycle in cervical cancer cells. Acta Biochim Pol. 2020, 67(2): 181-188 Search in Google Scholar

21 Kavčič N, Butinar M, Sobotič B,et.al. Intracellular cathepsin C levels determine sensitivity of cells to leucyl-leucine methyl ester-triggered apoptosis. FEBS J. 2020, 287(23): 5148-5166 Search in Google Scholar

22 Armentano B, Curcio R, Brindisi M,et.al. 5-(Carbamoylmethylene) oxazolidin-2-ones as a Promising Class of Heterocycles Inducing Apoptosis Triggered by Increased ROS Levels and Mitochondrial Dysfunction in Breast and Cervical Cancer. Biomedicines. 2020, 8(2). Search in Google Scholar

23 Tian Q, Wang L, Sun X, Zeng F, Pan Q, Xue M. Scopoletin exerts anticancer effects on human cervical cancer cell lines by triggering apoptosis, cell cycle arrest, inhibition of cell invasion and PI3K/AKT signalling pathway. J BUON. 2019, 24(3): 997-1002 Search in Google Scholar

24 Li D, Chen J, Ai Y, et.al. Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover. Mol Cell. 2019, 75(6): 11031116. Search in Google Scholar

25 Zhao Q, Wang W, Cui J. Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis. Cancer Cell Int. 2019, 19: 58. Search in Google Scholar

26 Jakovljević K, Joksović MD, Matić IZ, et.al. Novel 1,3,4-thiadiazolechalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies. Medchemcomm. 2018, 9(10): 1679-1697. Search in Google Scholar

27 Han YQ, Ming SL, Wu HT, et.al. Myostatin knockout induces apoptosis in human cervical cancer cells via elevated reactive oxygen species generation. Redox Biol. 2018, 19: 412-428. Search in Google Scholar

28 Hasson SS, H Al-Shubi AS, Al-Busaidi JZ, et.al. Potential of Aucklandia Lappa Decne Ethanolic Extract to Trigger Apoptosis of Human T47D and Hela Cells Asian Pac J Cancer Prev. 2018, 19(7): 1917-1925 Search in Google Scholar

29 Shao J, Wang C, Li L, et.al. Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells. Int J. Mol Sci. 2018, 19(6). Search in Google Scholar

30 Zhang FZ, Ho DH, Wong RH. Triptolide, a HSP90 middle domain inhibitor, induces apoptosis in triple manner. Oncotarget. 2018, 9(32): 22301-22315 Search in Google Scholar

31 Wang W, Liu X, Guo X, Quan H. Mitofusin-2 Triggers Cervical Carcinoma Cell Hela Apoptosis via Mitochondrial Pathway in Mouse Model. Cell Physiol Biochem. 2018, 46(1): 69-81. Search in Google Scholar

32 Wang DD, Wu QX, Pan WJ, Hussain S, Mehmood S, Chen Y. A novel polysaccharide from the Sarcodon aspratus triggers apoptosis in Hela cells via induction of mitochondrial dysfunction. Food Nutr Res. 2018, 62 Search in Google Scholar

33 Jaudan A, Sharma S, Malek SNA, Dixit A. Induction of apoptosis by pinostrobin in human cervical cancer cells: Possible mechanism of action. PLoS One. 2018, 3(2): e0191523 Search in Google Scholar

34 Plissonnier ML, Fauconnet S, Bittard H, Mougin C, Rommelaere J, Lascombe I. Cell death and restoration of TRAIL-sensitivity by ciglitazone in resistant cervical cancer cells. Oncotarget. 2017, 8(64): 107744-107762 Search in Google Scholar

35 Xu T, Pang Q, Wang Y, Yan X. Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells. Int J Mol Med. 2017, 40(6): 1669-1678 Search in Google Scholar

36 Singh PK, Roukounakis A, Frank DO, et.al. Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis. Genes Dev. 2017, 31(17): 1754-1769 Search in Google Scholar

37 Zhu X, Huang L, Gong J, et.al. NF-κB pathway link with ER stressinduced autophagy and apoptosis in cervical tumor cells. Cell Death Discov. 2017, 3: 17059. Search in Google Scholar

38 Cheriyamundath S, Raghavan R, Banerji A,et.al. Bioassay-Guided Isolation and Evaluation of Antiproliferative Effects of (Z)-Ethylidene-4, 6-Dimethoxycoumaran-3-One from Pogostemon Quadrifolius (Benth.) Asian Pac J Cancer Prev. 2017, 18(7): 1783-1790 Search in Google Scholar

39 Souza RP, Bonfim-Mendonça PS, Gimenes F, et.al. Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines. Oxid Med Cell Longev. 2017, 2017: 1512745. Search in Google Scholar

40 Woldetsadik AD, Vogel MC, Rabeh WM, Magzoub M. Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells. FASEB J. 2017, 31(5): 2168-2184 Search in Google Scholar

41 Zhang W, Che Q, Tan H et.al. Marine Streptomyces sp. derived antimycin analogues suppress HeLa cells via depletion HPV E6/E7 mediated by ROS-dependent ubiquitin-proteasome system. Sci Rep. 2017, 7: 42180 Search in Google Scholar

42 Sophonnithiprasert T, Mahabusarakam W, Nakamura Y, Watanapokasin R. Goniothalamin induces mitochondria-mediated apoptosis associated with endoplasmic reticulum stress-induced activation of JNK in HeLa cells. Oncol Lett. 2017, 13(1): 119-128 Search in Google Scholar

43 Lu P, Vander Mause ER, et.al. Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53. J Ovarian Res. 2019, 12(1): 45. Search in Google Scholar

44 Ma Q, Song J, Ma H, Gao K, Yang Y, He N. Synergistic anticancer effect of Grb2 and ITGA1 on cancer cells highly expressing Grb2 through suppressing ERK phosphorylation. Int J Clin Exp Pathol. 2019, 12(1): 182-189 Search in Google Scholar

45 Wen D, Zhang X, Ding L, et.al. Folic acid functionalized aggregationinduced emission nanoparticles for tumor cell targeted imaging and photodynamic therapy. RSC Adv. 2022, 12(8): 4484-4489. Search in Google Scholar

46 Toro-Cordova A, Flores-Cruz M, Santoyo-Salazar J, et.al. Liposomes Loaded with Cisplatin and Magnetic Nanoparticles: Physicochemical Characterization, Pharmacokinetics, and In-Vitro Efficacy. Molecules. 2018, 23(9). Search in Google Scholar

47 Handali S, Moghimipour E, Rezaei M, et.al. A novel 5-Fluorouracil targeted delivery to colon cancer using folic acid conjugated liposomes. Biomed Pharmacother. 2018, 108: 1259-1273. Search in Google Scholar