Metanephrine and Normetanephrine Urine Excretion in Patients with PCOS

1. Wolf WM, Wattick RA, Kinkade ON, Olfert MD. Geographical Prevalence of Polycystic Ovary Syndrome as Determined by Region and Race/Ethnicity. Int J Environ Res Public Health. 2018;15(11):2589.10.3390/ijerph15112589 Search in Google Scholar

2. Merkin SS, Phy JL, Sites CK, Yang D. Environmental determinants of polycystic ovary syndrome. Fertil Steril. 2016;106(1):16-24.10.1016/j.fertnstert.2016.05.011 Search in Google Scholar

3. Khan MJ, Ullah A, Basit S. Genetic Basis of Polycystic Ovary Syndrome (PCOS): Current Perspectives. Appl Clin Genet. 2019;12:249-260.10.2147/TACG.S200341 Search in Google Scholar

4. Ekpenyong CE, Davis KJ, Akpan UP, Daniel NE. Academic stress and menstrual disorders among female undergraduates in Uyo, South Eastern Nigeria – the need for health education. Niger J Physiol Sci. 2011;26(2):193-198. Search in Google Scholar

5. Rafique N, Al-Sheikh MH. Prevalence of menstrual problems and their association with psychological stress in young female students studying health sciences. Saudi Med J. 2018;39(1):67-73.10.15537/smj.2018.1.21438 Search in Google Scholar

6. Dokras A, Stener-Victorin E, Yildiz BO et al. Androgen Excess – Polycystic Ovary Syndrome Society: position statement on depression, anxiety, quality of life, and eating disorders in polycystic ovary syndrome. Fertil Steril. 2018;109(5):888-899.10.1016/j.fertnstert.2018.01.038 Search in Google Scholar

7. Livadas S, Chaskou S, Kandaraki AA et al. Anxiety is associated with hormonal and metabolic profile in women with polycystic ovarian syndrome. Clin Endocrinol (Oxf). 2011;75(5):698-703.10.1111/j.1365-2265.2011.04122.x Search in Google Scholar

8. Ilie IR. Neurotransmitter, neuropeptide and gut peptide profile in PCOS-pathways contributing to the pathophysiology, food intake and psychiatric manifestations of PCOS. Adv Clin Chem. 2020;96:85-135.10.1016/bs.acc.2019.11.004 Search in Google Scholar

9. Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res. 2002;53(4):865-871.10.1016/S0022-3999(02)00429-4 Search in Google Scholar

10. Kyrou I, Tsigos C. Chronic stress, visceral obesity and gonadal dysfunction. Hormones (Athens). 2008;7(4):287-293.10.14310/horm.2002.120919121989 Search in Google Scholar

11. Barber TM, Hanson P, Weickert MO, Franks S. Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies. Clin Med Insights Reprod Health. 2019;13:1179558119874042.10.1177/1179558119874042673459731523137 Search in Google Scholar

12. Benson S, Arck PC, Tan S et al. Disturbed stress responses in women with polycystic ovary syndrome. Psychoneuroendocrinology. 2009;34(5):727-35.10.1016/j.psyneuen.2008.12.00119150179 Search in Google Scholar

13. Teede HJ, Misso ML, Costello MF, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Hum Reprod. 2018;33(9):1602-1618.10.1093/humrep/dey256611257630052961 Search in Google Scholar

14. Dewailly D, Alebić MŠ, Duhamel A, Stojanović N. Using cluster analysis to identify a homogeneous subpopulation of women with polycystic ovarian morphology in a population of non-hyperandrogenic women with regular menstrual cycles. Hum Reprod. 2014 Nov;29(11):2536-43.10.1093/humrep/deu24225267785 Search in Google Scholar

15. Robeva R, Nedyalkova M, Kirilov G, et al. Multivariate Statistical Approach for Nephrines in Women with Obesity. Molecules. 2021;26(5):1393.10.3390/molecules26051393796188333807567 Search in Google Scholar

16. Lansdown A, Rees DA. The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target? Clin Endocrinol (Oxf). 2012;77(6):791-801.10.1111/cen.1200322882204 Search in Google Scholar

17. Lansdown AJ, Warnert EAH, Sverrisdóttir Y, Wise RG, Rees DA. Regional Cerebral Activation Accompanies Sympathoex-citation in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2019;104(9):3614-3623.10.1210/jc.2019-0006531127833 Search in Google Scholar

18. Garcia-Rudaz C, Armando I, Levin G et al. Peripheral catecholamine alterations in adolescents with polycystic ovary syndrome. Clin Endocrinol (Oxf). 1998;49(2):221-228.10.1046/j.1365-2265.1998.00511.x9828911 Search in Google Scholar

19. Mehde А, Mehdi W, Aboud W, Hmeed R. Utility of plasma free metanephrines for detecting insulin resistance in patients with PCOS. BCAIJ. 2014, 8(1), 44-49. Search in Google Scholar

20. Sam S, Vellanki P, Yalamanchi SK et al. Exaggerated glucagon responses to hypoglycemia in women with polycystic ovary syndrome. Metabolism. 2017;71:125-131.10.1016/j.metabol.2017.03.008546800428521865 Search in Google Scholar

21. Chaudhari NK, Nampoothiri LP. Neurotransmitter alteration in a testosterone propionate-induced polycystic ovarian syndrome rat model. Horm Mol Biol Clin Investig. 2017;29(2):71-77. Search in Google Scholar

22. Saller S, Merz-Lange J, Raffael S et al. Norepinephrine, active norepinephrine transporter, and norepinephrine-metabolism are involved in the generation of reactive oxygen species in human ovarian granulosa cells. Endocrinology. 2012;153(3):1472-1483.10.1210/en.2011-176922234472 Search in Google Scholar

23. Reimann M, Qin N, Gruber M et al. Adrenal medullary dysfunction as a feature of obesity. Int J Obes (Lond). 2017;41(5):714-721.10.1038/ijo.2017.3628163318 Search in Google Scholar

24. Zumoff B, Strain GW. A perspective on the hormonal abnormalities of obesity: are they cause or effect? Obes Res. 1994;2(1):56-67.10.1002/j.1550-8528.1994.tb00045.x Search in Google Scholar

25. Lopez MG, Abad F, Sancho C et al. Membrane-mediated effects of the steroid 17-α-estradiol on adrenal catecholamine release. J Pharmacol Exp Ther 1991;259(1):279-285. Search in Google Scholar

26. Park YH, Cho GS, Cho ET et al. Influence of 17-alpha-estradiol on catecholamine secretion from the perfused rat adrenal gland. Korean J Intern Med. 1996;11(1):25-39.10.3904/kjim.1996.11.1.25 Search in Google Scholar

27. De Miguel R, Fernández-Ruiz JJ, Hernández ML, Ramos JA. Role of ovarian steroids on the catecholamine synthesis and release in female rat adrenal: in vivo and in vitro studies. Life Sci. 1989;44(25):1979-86.10.1016/0024-3205(89)90411-6 Search in Google Scholar

28. Del Rio G, Velardo A, Menozzi R et al. Acute estradiol and progesterone administration reduced cardiovascular and catecholamine responses to mental stress in menopausal women. Neuroendocrinology. 1998;67(4):269-274.10.1159/000054322 Search in Google Scholar

29. Weise M, Eisenhofer G, Merke DP. Pubertal and gender-related changes in the sympathoadrenal system in healthy children. J Clin Endocrinol Metab. 2002;87(11):5038-5043.10.1210/jc.2002-020590 Search in Google Scholar

30. Heider U, Pedal I, Spanel-Borowski K. Increase in nerve fibers and loss of mast cells in polycystic and postmenopausal ovaries. Fertil Steril. 2001;75(6):1141-1147.10.1016/S0015-0282(01)01805-2 Search in Google Scholar

31. Dyer CA, Erickson GF. Norepinephrine amplifies human chorionic gonadotropin-stimulated androgen biosyn-thesis by ovarian theca-interstitial cells. Endocrinology. 1985;116(4):1645-1652.10.1210/endo-116-4-16453971933 Search in Google Scholar

32. Morales-Ledesma L, Linares R, Rosas G, et al. Unilateral sectioning of the superior ovarian nerve of rats with polycystic ovarian syndrome restores ovulation in the innervated ovary. Reprod Biol Endocrinol. 2010;8:99.10.1186/1477-7827-8-99293631620723258 Search in Google Scholar

33. Shorakae S, Lambert EA, Jona E et al. Effect of Central Sympathoinhibition With Moxonidine on Sympathetic Nervous Activity in Polycystic Ovary Syndrome-A Randomized Controlled Trial. Front Physiol. 2018;9:1486.10.3389/fphys.2018.01486621045230410448 Search in Google Scholar

34. Haidan A, Bornstein SR, Glasow A et al. Basal steroidogenic activity of adrenocortical cells is increased 10-fold by coculture with chromaffin cells. Endocrinology. 1998;139(2):772-780.10.1210/endo.139.2.57409449652 Search in Google Scholar

35. Ehrhart-Bornstein M, Bornstein SR, Güse-Behling H et al. Sympathoadrenal regulation of adrenal androstenedione release. Neuroendocrinology. 1994;59(4):406-412.10.1159/0001266858202222 Search in Google Scholar

36. Straub RH, Kittner JM, Heijnen C, Schedlowski M, Schmidt RE, Jacobs R. Infusion of epinephrine decreases serum levels of cortisol and 17-hydroxyprogesterone in patients with rheumatoid arthritis. J Rheumatol. 2002;29(8):1659-1664. Search in Google Scholar

37. Ehrhart-Bornstein M, Hinson JP, Bornstein SR, Scherbaum WA, Vinson GP. Intraadrenal interactions in the regulation of adrenocortical steroidogenesis. Endocr Rev. 1998;19(2):101-43.10.1210/edrv.19.2.03269570034 Search in Google Scholar

38. Ellulu MS, Patimah I, Khaza›ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017;13(4):851-863.10.5114/aoms.2016.58928550710628721154 Search in Google Scholar