Hyperthyroid GD (N = 32) | Euthyroid GD (N = 28) | ||
---|---|---|---|
IgG4 (mg/dL) | 33 (23.78; 58.3) | 52.4 (29.45; 95.6) | 0.061 |
Total IgG (g/L) | 11.72 (10.88; 13.09) | 10.65 (9.77; 12.34) | 0.098 |
TSH (μU/mL) | 0.01 (0.01; 0.01) | 1.55 (0.81; 2.25) | <0.001 |
fT3 (pmol/L) | 25.72 (17.35; 31.95) | 4.72 (4.44; 5.23) | <0.001 |
fT4 (pmol/L) | 48.91 (38.08; 79.9) | 15.14 (13.09; 16.01) | <0.001 |
TRAb (IU/I) | 13.23 (6.43; 23.31) | 2.09 (0.9; 3.98) | <0.001 |
TPOAb (IU/mL) | 246 (59.75; 410.75) | 63 (27; 147.25) | 0.004 |
TgAb (IU/mL) | 271 (35.25; 525.25) | 20.5 (10.75; 164) | 0.006 |
CRP (mg/dL) | 1.15 (0.5; 2.53) | 1.05 (0.48; 2.13) | 0.953 |
Moderate-to-severe GO (% of patients) | 9.38 | 32.14 | 0.050 |
IgG4 | Total IgG | |
---|---|---|
IgG4 | – | |
Total IgG | – | |
Age (years) | ||
CRP | ||
TSH | ||
fT3 | ||
fT4 | ||
TRAb | ||
TPOAb | ||
TgAb | ||
Creatinine | ||
ALT | ||
AST | ||
WBC | ||
RBC | ||
Hemoglobin | ||
PLT | ||
Thyroid volume | ||
Intrathyroidal blood flow | ||
Thyroid echogenicity | ||
Number of thyroid nodules |
GD patients with IgG4 serum concentration within normal range (N = 54) | GD patients with high IgG4 serum concentration (N = 6) | ||
---|---|---|---|
IgG4 (mg/dL) | 33.9 (25.73; 67.8) | 159.5 (143.78; 174.93) | <0.001 |
Total IgG (g/L) | 11.25 (10.31; 12.4) | 11.39 (10.69; 14.58) | 0.411 |
Age (years) | 39.96 ± 13.44 | 38.83 ± 11.84 | 0.844 |
Gender (% of males) | 14 (25.93%) | 1 (16.67%) | 1 |
TSH (μIU/mL) | 0.01 (0.01; 1.33) | 1.54 (0.34; 1.94) | 0.095 |
fT3 (pmol/L) | 10.78 (4.74; 26.2) | 6.06 (4.93; 6.76) | 0.498 |
fT4 (pmol/L) | 30.16 (15.4; 53.4) | 15 (13.18; 18.33) | 0.112 |
TRAb (IU/I) | 6.03 (2.56; 16.82) | 2.68 (1.54; 3.56) | 0.078 |
TPOAb (IU/mL) | 122.5 (31.25; 281) | 218 (154.5; 280.75) | 0.538 |
TgAb (IU/mL) | 71 (13; 325) | 246 (84.5; 554.5) | 0.204 |
CRP (mg/dL) | 6.03 (2.56; 16.82) | 2.68 (1.54; 3.56) | 0.408 |
Creatinine (mg/mL) | 0.57 (0.44; 0.73) | 0.62 (0.57; 0.73) | 0.267 |
ALT (U/I) | 23.5 (17.25; 32) | 24.5 (17.25; 28.75) | 0.970 |
AST (U/I) | 21.5 (16; 25) | 22.5 (20.25; 26.25) | 0.330 |
WBC (×103/μL) | 6.46 ± 1.75 | 6.35 ± 2.3 | 0.878 |
RBC (×106/μL) | 4.71 ± 0.4 | 4.76 ± 0.18 | 0.802 |
Hemoglobin (g/mL) | 13.55 (12.63; 14.38) | 14.1 (13.6; 14.38) | 0.810 |
PLT (×103/μL) | 4.71 ± 0.4 | 4.76 ± 0.18 | 0.802 |
Thyroid volume (cm3) | 29.82 ± 21.83 | 19.35 ± 15.25 | 0.233 |
Intrathyroidal blood flow | 1 (0; 2) | 1 (0.25; 1.75) | 0.707 |
Thyroid echogenicity | 1 (1; 2) | 1 (1; 1.75) | 0.792 |
Presence of any thyroid nodule (% of patients) | 36.73 | 16.67 | 0.653 |
Presence of multiple (≥3) thyroid nodules (% of patients) | 18.37 | 0 | 0.574 |
Moderate-to-severe GO (% of patients) | 14.81 | 66.67 | 0.012 |