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Perfluorooctanoic acid affects mouse brain and liver tissue through oxidative stress

Burcu Ünlü Endirlik

Burcu Ünlü Endirlik

  • Erciyes University Faculty of Pharmacy, Department of Pharmaceutical ToxicologyKayseri, Turkey
  • Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical ToxicologyAnkara, Turkey
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Endirlik, Burcu Ünlü
, 
Ayşe Eken

Ayşe Eken

Erciyes University Faculty of Pharmacy, Department of Pharmaceutical ToxicologyKayseri, Turkey
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Eken, Ayşe
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Hande Canpınar

Hande Canpınar

Hacettepe University Cancer Institute, Department of Basic OncologyAnkara, Turkey
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Canpınar, Hande
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Figen Öztürk

Figen Öztürk

Erciyes University Faculty of Medicine, Department of PathologyKayseri, Turkey
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Öztürk, Figen
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Aylin Gürbay

Aylin Gürbay

Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical ToxicologyAnkara, Turkey
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Gürbay, Aylin
  
07 lug 2022
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Categoria dell'articolo: Original article
Pubblicato online: 07 lug 2022
Pagine: 148 - 157
Ricevuto: 01 feb 2022
Accettato: 01 apr 2022
DOI: https://doi.org/10.2478/aiht-2022-73-3629
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© 2022 Burcu Ünlü Endirlik, Ayşe Eken, Hande Canpınar, Figen Öztürk, and Aylin Gürbay, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Histopathological changes in mouse brain tissue stained with hematoxylin and eosin (200× magnification). A – control; B – PFOA dose of 15 mg/kg bw; C – PFOA dose of 30 mg/kg bw; D – taurine dose of 100 mg/kg bw; E – taurine+PFOA dose of 30 mg/kg bw; F – corn oil; G – CoQ10 dose of 50 mg/kg bw; H – CoQ10+PFOA dose of 30 mg/kg bw
Histopathological changes in mouse brain tissue stained with hematoxylin and eosin (200× magnification). A – control; B – PFOA dose of 15 mg/kg bw; C – PFOA dose of 30 mg/kg bw; D – taurine dose of 100 mg/kg bw; E – taurine+PFOA dose of 30 mg/kg bw; F – corn oil; G – CoQ10 dose of 50 mg/kg bw; H – CoQ10+PFOA dose of 30 mg/kg bw

Figure 2

Histopathological changes in mouse liver tissue stained with hematoxylin and eosin (200× magnification). A – control; B – PFOA dose of 15 mg/kg bw; C – PFOA dose of 30 mg/kg bw; D – taurine dose of 100 mg/kg bw; E – taurine+PFOA dose of 30 mg/kg bw; F – corn oil; G – CoQ10 dose of 50 mg/kg bw; H – CoQ10+PFOA dose of 30 mg/kg bw. Arrows: CV – central vein; H – hepatocellular hypertrophy; E – eosinophilic cytoplasm; B – balloon degeneration; FN – focal necrosis; N – necrosis; A – acidophilic cytoplasm
Histopathological changes in mouse liver tissue stained with hematoxylin and eosin (200× magnification). A – control; B – PFOA dose of 15 mg/kg bw; C – PFOA dose of 30 mg/kg bw; D – taurine dose of 100 mg/kg bw; E – taurine+PFOA dose of 30 mg/kg bw; F – corn oil; G – CoQ10 dose of 50 mg/kg bw; H – CoQ10+PFOA dose of 30 mg/kg bw. Arrows: CV – central vein; H – hepatocellular hypertrophy; E – eosinophilic cytoplasm; B – balloon degeneration; FN – focal necrosis; N – necrosis; A – acidophilic cytoplasm

Figure 3

Total MDA and GSH levels in brain and liver tissues of mice treated with PFOA, taurine, and CoQ10 (data are expressed as medians and interquartile ranges, n=6 for water and corn oil groups; n=7 for treated groups). ap<0.01 and fp<0.05 relative to control; bp<0.01 and gp<0.05 relative to taurine; cp<0.01 relative to PFOA (30 mg/kg); dp<0.05 and hp<0.01 relative to corn oil; ep<0.05 and ip<0.01 relative to CoQ10
Total MDA and GSH levels in brain and liver tissues of mice treated with PFOA, taurine, and CoQ10 (data are expressed as medians and interquartile ranges, n=6 for water and corn oil groups; n=7 for treated groups). ap<0.01 and fp<0.05 relative to control; bp<0.01 and gp<0.05 relative to taurine; cp<0.01 relative to PFOA (30 mg/kg); dp<0.05 and hp<0.01 relative to corn oil; ep<0.05 and ip<0.01 relative to CoQ10

Figure 4

Antioxidant enzyme activity in brain and liver tissues of mice treated with PFOA, taurine, and CoQ10. (data are expressed as medians and interquartile ranges, n=6 for water and corn oil groups; n=7 for treated groups). ap<0.01 and gp<0.05 relative to PFOA (30 mg/kg); bp<0.01 and fp<0.05 relative to corn oil; cp<0.01 relative to CoQ10; dp<0.01 relative to control; ep<0.05 and hp<0.01 relative to taurine
Antioxidant enzyme activity in brain and liver tissues of mice treated with PFOA, taurine, and CoQ10. (data are expressed as medians and interquartile ranges, n=6 for water and corn oil groups; n=7 for treated groups). ap<0.01 and gp<0.05 relative to PFOA (30 mg/kg); bp<0.01 and fp<0.05 relative to corn oil; cp<0.01 relative to CoQ10; dp<0.01 relative to control; ep<0.05 and hp<0.01 relative to taurine

Figure 5

Distribution of liver cells by cycle in mice treated with, PFOA, taurine, and CoQ10 (data are expressed as medians, n=3). ap<0.05 relative to the PFOA (30 mg/kg) group
Distribution of liver cells by cycle in mice treated with, PFOA, taurine, and CoQ10 (data are expressed as medians, n=3). ap<0.05 relative to the PFOA (30 mg/kg) group

Body weight and relative brain and liver weight changes in mice treated with oral PFOA, CoQ10, and taurine

Groups Body weight change from baseline (%) Relative brain weight (g/100 g) Relative liver weight (g/100 g)
Control (water) 3.03 (-6.43–8.14) 1.25 (1.19–1.36) 5.39 (5.00–5.82)
PFOA (15 mg/kg) -11.76a (-14.71–8.33) 1.50 (1.30–1.62) 15.71d (14.67–15.91)
PFOA (30 mg/kg) -21.21a (-28.57–0) 1.51a (1.27–1.65) 15.79d (15.00–17.44)
Taurine -3.23 (-10.81–2.56) 1.28 (1.18–1.45) 5.09 (5.03–5.59)
Taurine + PFOA -13.33 (-16.67–3.23) 1.46 (1.32–1.54) 16.00d,e (15.71–16.40)
Corn oil -4.37 (-12.42–2.03) 1.33 (1.19–1.48) 5.47 (4.58–6.23)
CoQ10 -7.89 (-8.33–0) 1.30 (1.24–1.36) 5.15 (5.15–5.37)
CoQ10 + PFOA -17.65b,c (-22.86–9.38) 1.37 (1.36–1.56) 15.86f,g (13.09–17.04)
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