This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Taevernier L, Bracke N, Veryser L, Wynendaele E, Gevaert B, Peremans K, De Spiegeleer B. Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins. Toxicol Lett 2016;258:175–84. doi: 10.1016/j.toxlet.2016.06.1741TaevernierLBrackeNVeryserLWynendaeleEGevaertBPeremansKDeSpiegeleer BBlood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins20162581758410.1016/j.toxlet.2016.06.174127349679Open DOISearch in Google Scholar
Sava V, Reunova O, Velasquez A, Harbison R, Sánchez-Ramos J. Acute neurotoxic effects of the fungal metabolite ochratoxin-A. Neurotoxicology 2006;27:82–92. doi: 10.1016/j.neuro.2005.07.004SavaVReunovaOVelasquezAHarbisonRSánchez-RamosJAcute neurotoxic effects of the fungal metabolite ochratoxin-A200627829210.1016/j.neuro.2005.07.00416140385Open DOISearch in Google Scholar
Ren ZH, Deng HD, Deng YT, Deng JL, Zuo ZC, Yu SM, Shen LH, Cui HM, Xu ZW, Hu YC. Effect of the Fusarium toxins, zearalenone and deoxynivalenol, on the mouse brain. Environ Toxicol Pharma 2016;46:62–70. doi: 10.1016/j.etap.2016.06.028RenZHDengHDDengYTDengJLZuoZCYuSMShenLHCuiHMXuZWHuYCEffect of the Fusarium toxins, zearalenone and deoxynivalenol, on the mouse brain201646627010.1016/j.etap.2016.06.02827438895Open DOISearch in Google Scholar
Islam MT, Mishra SK, Tripathi S, de Alencar MVOB, Sousa JMDC, Rolim HML, Graças M, Medeiros F, Ferreira PMP, Rouf R, Uddin SJ, Mubarak MS, de Carvalho Melo-Cavalcante AA. Mycotoxin-assisted mitochondrial dysfunction and cytotoxicity: Unexploited tools against proliferative disorders. IUBMB life 2018;70:1084–92. doi: 10.1002/iub.1932IslamMTMishraSKTripathiSdeAlencar MVOBSousaJMDCRolimHMLGraçasMMedeirosFFerreiraPMPRoufRUddinSJMubarakMSdeCarvalho Melo-Cavalcante AAMycotoxin-assisted mitochondrial dysfunction and cytotoxicity: Unexploited tools against proliferative disorders20187010849210.1002/iub.193230180298Open DOISearch in Google Scholar
Escrivá L, Jennen D, Caiment F, Manyes L. Transcriptomic study of the toxic mechanism triggered by beauvericin in Jurkat cells. Toxicol lett 2018;284:213–21. doi: 10.1016/j.toxlet.2017.11.035EscriváLJennenDCaimentFManyesLTranscriptomic study of the toxic mechanism triggered by beauvericin in Jurkat cells20182842132110.1016/j.toxlet.2017.11.03529203277Open DOISearch in Google Scholar
Niaz K, Shah SZA, Khan F, Bule M. Ochratoxin A–induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies. Environ Sci Pollut 2020;27:44673–700. doi: 10.1007/s11356-020-08991-yNiazKShahSZAKhanFBuleMOchratoxin A–induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies2020274467370010.1007/s11356-020-08991-y32424756Open DOISearch in Google Scholar
Luciani P, Deledda C, Rosati F, Benvenuti S, Cellai I, Dichiara F, Morello M, Vannelli GB, Danza G, Serio M, Peri A. Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures. Endocrinology 2008;149:4256–66. doi: 10.1210/en.2007-1795LucianiPDeleddaCRosatiFBenvenutiSCellaiIDichiaraFMorelloMVannelliGBDanzaGSerioMPeriASeladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures200814942566610.1210/en.2007-179518499757Open DOISearch in Google Scholar
Juan-García A, Montesano D, Mañes J, Juan C. Cytoprotective effects of carotenoids-rich extract from Lycium barbarum L. on the beauvericin-induced cytotoxicity on Caco-2 cells. Food Chem Toxicol 2019;133:110798. doi: 10.1016/j.fct.2019.110798Juan-GarcíaAMontesanoDMañesJJuanCCytoprotective effects of carotenoids-rich extract from Lycium barbarum L201913311079810.1016/j.fct.2019.11079831473340Open DOISearch in Google Scholar
Montesano D, Juan-García A, Mañes J, Juan C. Chemoprotective effect of carotenoids from Lycium barbarum L. on SH-SY5Y neuroblastoma cells treated with beauvericin. Food Chem Toxicol 2020;141:111414. doi: 10.1016/j.fct.2020.111414MontesanoDJuan-GarcíaAMañesJJuanCChemoprotective effect of carotenoids from Lycium barbarum L202014111141410.1016/j.fct.2020.11141432387444Open DOISearch in Google Scholar
Alonso-Garrido M, Tedeschi P, Maietti A, Font G, Marchetti N, Manyes L. Mitochondrial transcriptional study of the effect of aflatoxins, enniatins and carotenoids in vitro in a blood brain barrier model. Food Chem Toxicol 2020;137:111077. doi: 10.1016/j.fct.2019.111077Alonso-GarridoMTedeschiPMaiettiAFontGMarchettiNManyesLMitochondrial transcriptional study of the effect of aflatoxins, enniatins and carotenoids in vitro in a blood brain barrier model202013711107710.1016/j.fct.2019.11107731904472Open DOISearch in Google Scholar
McGill CR, Green NR, Meadows MC, Gropper SS. Beta-carotene supplementation decreases leukocyte superoxide dismutase activity and serum glutathione peroxidase concentration in humans. J Nutr Biochem 2003;14:656–62. doi: 10.1016/j.jnutbio.2003.08.003McGillCRGreenNRMeadowsMCGropperSSBeta-carotene supplementation decreases leukocyte superoxide dismutase activity and serum glutathione peroxidase concentration in humans2003146566210.1016/j.jnutbio.2003.08.003Open DOISearch in Google Scholar
Zhang P, Omaye ST. β-Carotene: Interactions with α-tocopherol and ascorbic acid in microsomal lipid peroxidation. J Nutr Biochem 2001;12:38–45. doi: 10.1016/S0955-2863(00)00143-1ZhangPOmayeSTβ-Carotene: Interactions with α-tocopherol and ascorbic acid in microsomal lipid peroxidation200112384510.1016/S0955-2863(00)00143-1Open DOISearch in Google Scholar
Kim JH, Hwang J, Shim E, Chung EJ, Jang SH, Koh SB. Association of serum carotenoid, retinol, and tocopherol concentrations with the progression of Parkinson’s Disease. Nutr Res Pract 2017;11:114–20. doi: 10.4162/nrp.2017.11.2.114KimJHHwangJShimEChungEJJangSHKohSBAssociation of serum carotenoid, retinol, and tocopherol concentrations with the progression of Parkinson’s Disease2017111142010.4162/nrp.2017.11.2.114537652928386384Open DOISearch in Google Scholar
Mullan K, Williams MA, Cardwell CR, McGuinness B, Passmore P, Silvestri G, Woodside JV, McKay GJ. Serum concentrations of vitamin E and carotenoids are altered in Alzheimer’s disease: A case-control study. Alzheimers Dement 2017;3:432–9. doi: 10.1016/j.trci.2017.06.006MullanKWilliamsMACardwellCRMcGuinnessBPassmorePSilvestriGWoodsideJVMcKayGJSerum concentrations of vitamin E and carotenoids are altered in Alzheimer’s disease: A case-control study20173432910.1016/j.trci.2017.06.006565143129067349Open DOISearch in Google Scholar
Deng P, Li X, Petriello MC, Wang C, Morris AJ, Hennig B. Application of metabolomics to characterize environmental pollutant toxicity and disease risks. Rev Environ Health 2019;34:251–9. doi: 10.1515/reveh-2019-0030DengPLiXPetrielloMCWangCMorrisAJHennigBApplication of metabolomics to characterize environmental pollutant toxicity and disease risks201934251910.1515/reveh-2019-0030691504031408434Open DOISearch in Google Scholar
Bergantin C, Maietti A, Tedeschi P, Font G, Manyes L, Marchetti N. HPLC-UV/Vis-APCI-MS/MS determination of major carotenoids and their bioaccessibility from “Delica” (Cucurbita maxima) and “Violina” (Cucurbita moschata) pumpkins as food traceability markers. Molecules 2018;23:2791. doi: 10.3390/molecules23112791BergantinCMaiettiATedeschiPFontGManyesLMarchettiNHPLC-UV/Vis-APCI-MS/MS determination of major carotenoids and their bioaccessibility from “Delica” (Cucurbita maxima) and “Violina” (Cucurbita moschata) pumpkins as food traceability markers201823279110.3390/molecules23112791627825730373266Open DOISearch in Google Scholar
Stuerenburg HJ, Ganzer S, Muller-Thomsen T. Plasma betacarotene in Alzheimer’s disease. Association with cerebrospinal fluid beta-amyloid 1-40, (Abeta40), beta-amyloid 1-42 (Abeta42) and total Tau. Neuroendocrinol Lett 2005;26:696–8. PMID: 16380679StuerenburgHJGanzerSMuller-ThomsenTPlasma betacarotene in Alzheimer’s disease2005266968PMID: 16380679Search in Google Scholar
Yuan J-F, Ji H-H, Qiu Z-J, Wang D-H. ECV304/C6 coculture model of the BBB coupled with LC–MS analysis for drug screening from Rhubarb extract. Med Chem Res 2016;25:1935–44. doi: 10.1007/s00044-016-1618-7YuanJ-FJiH-HQiuZ-JWangD-HECV304/C6 coculture model of the BBB coupled with LC–MS analysis for drug screening from Rhubarb extract20162519354410.1007/s00044-016-1618-7Open DOISearch in Google Scholar
Blackwell A, Aja S, Zhou W, Graham D, Ronnett GV. Multi-Omics Compatible Protocols for Preparation and Extraction of Biological Samples for Wide Coverage in Untargeted Metabolomics Experiments. [displayed 24 August 2021]. Available at https://www.agilent.com/cs/library/technicaloverviews/Public/5991-3528EN.pdfBlackwellAAjaSZhouWGrahamDRonnettGV[displayed 24 August2021Available athttps://www.agilent.com/cs/library/technicaloverviews/Public/5991-3528EN.pdfSearch in Google Scholar
Montenegro-Burke JR, Guijas C, Siuzdak G. Metlin: A tandem mass spectral library of standards. In: Li S, editor. Computational methods and data analysis for metabolomics. Springer US, 2020. p. 149–63.Montenegro-BurkeJRGuijasCSiuzdakGMetlin: A tandem mass spectral library of standardsLiSeditorSpringer US2020149–6310.1007/978-1-0716-0239-3_931953817Search in Google Scholar
Jassal B, Matthews L, Viteri G, Gong C, Lorente P, Fabregat A, Sidiropoulos K, Cook J, Gillespie M, Haw R, Loney F, May B, Milacic M, Rothfels K, Sevilla C, Shamovsky V, Shorser S, Varusai T, Weiser J, Wu G, Stein L, Hermjakob H, D’Eustachio P. The reactome pathway knowledgebase. Nucleic Acids Res 2020;48:D498–503. doi: 10.1093/nar/gkz1031JassalBMatthewsLViteriGGongCLorentePFabregatASidiropoulosKCookJGillespieMHawRLoneyFMayBMilacicMRothfelsKSevillaCShamovskyVShorserSVarusaiTWeiserJWuGSteinLHermjakobHD’EustachioPThe reactome pathway knowledgebase202048D49850310.1093/nar/gkz1031714571231691815Open DOISearch in Google Scholar
Hoggatt J, Pelus LM. Eicosanoid regulation of hematopoiesis and hematopoietic stem and progenitor trafficking. Leukemia 2010;24:1993–2002. doi: 10.1038/leu.2010.216HoggattJPelusLMEicosanoid regulation of hematopoiesis and hematopoietic stem and progenitor trafficking2010241993200210.1038/leu.2010.216309959420882043Open DOISearch in Google Scholar
Alhouayek M, Masquelier J, Cani PD, Lambert DM, Muccioli GG. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. PNAS 2013;110:17558–63. doi: 10.1073/pnas.1314017110AlhouayekMMasquelierJCaniPDLambertDMMuccioliGGImplication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD62013110175586310.1073/pnas.1314017110Open DOISearch in Google Scholar
Tallima H, El Ridi R. Arachidonic acid: Physiological roles and potential health benefits – A review. J Advanced Res 2018;11:33–41. doi: 10.1016/j.jare.2017.11.004TallimaHElRidi RArachidonic acid: Physiological roles and potential health benefits – A review201811334110.1016/j.jare.2017.11.004Open DOISearch in Google Scholar
Hanna VS, Hafez EAA. Synopsis of arachidonic acid metabolism: A review. J Adv Res 2018;11:23–32. doi: 10.1016/j.jare.2018.03.005HannaVSHafezEAASynopsis of arachidonic acid metabolism: A review201811233210.1016/j.jare.2018.03.005Open DOISearch in Google Scholar
Sarker MH, Hu D-E, Fraser PA. Acute effects of bradykinin on cerebral microvascular permeability in the anaesthetized rat. J Physiology 2000 ; 528:177–87. doi : 10.1111/j.1469-7793.2000.00177.xSarkerMHHuD-EFraserPAAcute effects of bradykinin on cerebral microvascular permeability in the anaesthetized rat20005281778710.1111/j.1469-7793.2000.00177.xOpen DOISearch in Google Scholar
Easton AS, Abbott NJ. Bradykinin increases permeability by calcium and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood-brain barrier. Brain Res 2002;953:157–69. doi: 10.1016/S0006-8993(02)03281-XEastonASAbbottNJBradykinin increases permeability by calcium and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood-brain barrier20029531576910.1016/S0006-8993(02)03281-XOpen DOISearch in Google Scholar
Juan-García A, Carbone S, Ben-Mahmoud M, Sagratini G, Mañes J. Beauvericin and ochratoxin A mycotoxins individually and combined in HepG2 cells alter lipid peroxidation, levels of reactive oxygen species and glutathione. Food Chem Toxicol 2020;139:111247. doi: 10.1016/j.fct.2020.111247Juan-GarcíaACarboneSBen-MahmoudMSagratiniGMañesJBeauvericin and ochratoxin A mycotoxins individually and combined in HepG2 cells alter lipid peroxidation, levels of reactive oxygen species and glutathione202013911124710.1016/j.fct.2020.11124732165234Open DOISearch in Google Scholar
Xiao Y, Xu S, Zhao S, Liu K, Lu Z, Hou Z. Protective effects of selenium against zearalenone-induced apoptosis in chicken spleen lymphocyte via an endoplasmic reticulum stress signaling pathway. Cell Stress Chaperones 2019;24:77–89. doi: 10.1007/s12192-018-0943-9XiaoYXuSZhaoSLiuKLuZHouZProtective effects of selenium against zearalenone-induced apoptosis in chicken spleen lymphocyte via an endoplasmic reticulum stress signaling pathway201924778910.1007/s12192-018-0943-9636362230374880Open DOISearch in Google Scholar
Guest J, Grant R. Carotenoids and neurobiological health. Adv Neurobiol 2016;12:199–228. doi: 10.1007/978-3-31928383-8_11GuestJGrantRCarotenoids and neurobiological health20161219922810.1007/978-3-31928383-8_11Open DOISearch in Google Scholar
Jucá MM, Cysne Filho FMS, de Almeida JC, Mesquita DDS, Barriga JRM, Dias KCF, Barbosa TM, Vasconcelos LC, Leal LKAM, Ribeiro JE, Vasconcelos SMM. Flavonoids: biological activities and therapeutic potential. Nat Prod Res 2020;34:692–705. doi: 10.1080/14786419.2018.1493588JucáMMCysneFilho FMSdeAlmeida JCMesquitaDDSBarrigaJRMDiasKCFBarbosaTMVasconcelosLCLealLKAMRibeiroJEVasconcelosSMMFlavonoids: biological activities and therapeutic potential20203469270510.1080/14786419.2018.149358830445839Open DOISearch in Google Scholar
Mallebrera B, Maietti A, Tedeschi P, Font G, Ruiz MJ, Brandolini V. Antioxidant capacity of trans-resveratrol dietary supplements alone or combined with the mycotoxin beauvericin. Food Chem Toxicol 2017;105:315–8. doi: 10.1016/j.fct.2017.04.027MallebreraBMaiettiATedeschiPFontGRuizMJBrandoliniVAntioxidant capacity of trans-resveratrol dietary supplements alone or combined with the mycotoxin beauvericin2017105315810.1016/j.fct.2017.04.02728450129Open DOISearch in Google Scholar
Subagio A, Morita N. Instability of carotenoids is a reason for their promotion on lipid oxidation. Food Res Int 2001;34:183–8. doi: 10.1016/S0963-9969(00)00150-2SubagioAMoritaNInstability of carotenoids is a reason for their promotion on lipid oxidation200134183810.1016/S0963-9969(00)00150-2Open DOISearch in Google Scholar
Mallebrera B, Prosperini A, Font G, Ruiz, MJ. In vitro mechanisms of Beauvericin toxicity: A review. Food Chem Toxicol 2018;111:537–45. doi: 10.1016/j.fct.2017.11.019MallebreraBProsperiniAFontGRuizMJIn vitro mechanisms of Beauvericin toxicity: A review20181115374510.1016/j.fct.2017.11.01929154952Open DOISearch in Google Scholar