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Pharmacological targeting of PD-L1/PD-1 signaling in gynecological cancers

Ammad Ahmad Farooqi

Ammad Ahmad Farooqi

Institute of Biomedical and Genetic Engineering (IBGE)Islamabad, Pakistan
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Farooqi, Ammad Ahmad
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Gürkan Özbey

Gürkan Özbey

Faculty of Medicine, Department of Obstetrics and Gynecology, Adiyaman UniversityAdiyaman, Turkiye
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Özbey, Gürkan
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Sundas Fayyaz

Sundas Fayyaz

School of Advanced Technologies and Natural Sciences, Western Caspian UniversityBaku, Azerbaijan
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Fayyaz, Sundas
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Cristina Donfrancesco

Cristina Donfrancesco

Department of Experimental Medicine, University of Rome “Sapienza”Rome, Italy
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Donfrancesco, Cristina
  
05 mar 2025
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Categoria dell'articolo: Review
Pubblicato online: 05 mar 2025
Pagine: 25 - 34
Ricevuto: 28 giu 2024
Accettato: 27 gen 2025
DOI: https://doi.org/10.2478/ahem-2025-0004
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© 2025 Ammad Ahmad Farooqi et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

PD-L1/PD-1 signaling causes exhaustion of natural killer cells and T cells
PD-L1/PD-1 signaling causes exhaustion of natural killer cells and T cells

Figure 2.

c-Myc and STAT3 transcriptionally upregulate PD-L1. FOXO3 inhibits the expression of PD-L1
c-Myc and STAT3 transcriptionally upregulate PD-L1. FOXO3 inhibits the expression of PD-L1

Figure 3.

(A-B) GATA1 transcriptionally activates LINC01503. LINC01503 interferes with miR-766-5p-mediated targeting of PD-L1. (C) PVT1 activates STAT3 signaling and consequent upregulation of PD-L1
(A-B) GATA1 transcriptionally activates LINC01503. LINC01503 interferes with miR-766-5p-mediated targeting of PD-L1. (C) PVT1 activates STAT3 signaling and consequent upregulation of PD-L1
Lingua:
Inglese
Frequenza di pubblicazione:
1 volte all'anno
Argomenti della rivista:
Scienze biologiche, Biologia molecolare, Microbiologia e virologia, Medicina, Scienze medicali di base, Immunologia
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