Variable | Patients with AS (n=13) | Controls (n=9) | |
---|---|---|---|
Age, years | 66 [60–70] | 59 [58–65] | 0.148 |
Male, n (%) | 10 (76.9) | 7 (77.8) | 0.991 |
Body mass index, kg m−2 | 31.2 ±5.4 | 24 ±6.5 | 0.002 |
Risk factors, n (%) | |||
Arterial hypertension | 12 (92.3) | 0 | ND |
Current smoking | 1 (7.7) | 0 | ND |
Medications, n (%) | |||
Beta-blockers | 11 (84.6) | 0 | ND |
Acetylsalicylic acid | 7 (53.8) | 0 | ND |
Angiotensin converting enzyme inhibitors | 9 (69.2) | 0 | ND |
Statins | 10 (76.9) | 0 | ND |
Echocardiographic parameters | |||
Aortic valve area, cm2 | 0.86 [0.8–0.9] | ND | |
Mean gradient, mmHg | 48 ±10.0 | ND | |
Maximum gradient, mmHg | 80 ±15.4 | ND | |
Peak transvalvular velocity, m/s | 4.5 ± 0.4 | ND | |
Left ventricular ejection fraction, % | 52.3 ±12.5 | ND | |
Laboratory investigation | |||
White blood cells, 103/µl | 6.2 ±1.4 | 6.5 ±1.7 | 0.655 |
Neutrophils, 103/µl | 3.5 [2.9–4.0] | 3.2 [2.3–3.6] | 0.189 |
Creatinine, µmol/L | 96 [86–100] | 67 [48–76] | 0.003 |
C-reactive protein, mg/L | 1.5 [1.0–2.5] | 0.99 [0.99–1.46] | 0.015 |
Glucose, mmol/L | 5.2 [5.0–5.6] | 5.0 [4.7–5.4] | 0.115 |
Total cholesterol, mmol/L | 4.2±1.1 | 4.9±0.9 | 0.131 |
Low density lipoprotein cholesterol, mmol/L | 2.9±1.0 | 3.0±1.1 | 0.827 |
High density lipoprotein cholesterol, mmol/L | 1.1±0.3 | 1.4±0.3 | 0.032 |
Triglycerides, mmol/L | 1.7±0.7 | 1.5±0.7 | 0.518 |