Molekularne mechanizmy działania czynnika transkrypcyjnego FOXN1 w skórze

[1]Slominski A.T., Manna P.R., Tuckey R.C.: On the role of skin in the regulation of local and systemic steroidogenic activities. Steroids, 2015; 103: 72-88 Slominski A.T. Manna P.R. Tuckey R.C. On the role of skin in the regulation of local and systemic steroidogenic activities Steroids 2015 103 72 8810.1016/j.steroids.2015.04.006463169425988614Search in Google Scholar

[2]Slominski A.T., Zmijewski M.A., Skobowiat C., Zbytek B., Slominski R.M., Steketee J.D.: Sensing the environment: Regulation of local and global homeostasis by the skin’s neuroendocrine system. Adv. Anat. Embryol. Cell Biol., 2012; 212: 1-115 Slominski A.T. Zmijewski M.A. Skobowiat C. Zbytek B. Slominski R.M. Steketee J.D. Sensing the environment: Regulation of local and global homeostasis by the skin’s neuroendocrine system Adv. Anat. Embryol. Cell Biol 2012 212 1 11510.1007/978-3-642-19683-6Search in Google Scholar

[3]Dai X., Segre J.A.: Transcriptional control of epidermal specification and differentiation. Curr. Opin. Genet. Dev., 2004; 14: 485-491 Dai X. Segre J.A. Transcriptional control of epidermal specification and differentiation Curr. Opin. Genet. Dev 2004 14 485 49110.1016/j.gde.2004.07.002289337915380238Search in Google Scholar

[4]Clark R.A.: Wound repair: Overview and general considerations. W: Clark R.A.F. (red.): The Molecular, Cellular Biology of Wound Repair, red.: R.A. Clark. Plenum Press, New York, 1996: 3-35 Clark R.A. Wound repair: Overview and general considerations W: Clark R.A.F. (red.): The Molecular, Cellular Biology of Wound Repair, red Clark R.A. Plenum Press New York 1996 3 3510.1007/978-1-4615-1795-5_1Search in Google Scholar

[5]Driskell R.R., Lichtenberger B.M., Hoste E., Kretzschmar K., Simons B.D., Charalambous M., Ferron S.R., Herault Y., Pavlovic G., Ferguson-Smith A.C., Watt F.M.: Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature, 2013; 504: 277-281 Driskell R.R. Lichtenberger B.M. Hoste E. Kretzschmar K. Simons B.D. Charalambous M. Ferron S.R. Herault Y. Pavlovic G. Ferguson-Smith A.C. Watt F.M. Distinct fibroblast lineages determine dermal architecture in skin development and repair Nature 2013 504 277 28110.1038/nature12783386892924336287Search in Google Scholar

[6]Marsh E., Gonzalez D.G., Lathrop E.A., Boucher J., Greco V.: Positional stability and membrane occupancy define skin fibroblast homeostasis in vivo. Cell, 2018; 175: 1620-1633.e13 Marsh E. Gonzalez D.G. Lathrop E.A. Boucher J. Greco V. Positional stability and membrane occupancy define skin fibroblast homeostasis in vivo Cell 2018 175 1620 163310.1016/j.cell.2018.10.013760501530415836Search in Google Scholar

[7]Rinkevich Y., Walmsley G.G., Hu M.S., Maan Z.N., Newman A.M., Drukker M., Januszyk M., Krampitz G.W., Gurtner G.C., Lorenz H.P. i wsp.: Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential. Science, 2015; 348: aaa2151 Rinkevich Y. Walmsley G.G. Hu M.S. Maan Z.N. Newman A.M. Drukker M. Januszyk M. Krampitz G.W. Gurtner G.C. Lorenz H.P. i wsp Skin fibrosis Identification and isolation of a dermal lineage with intrinsic fibrogenic potential. Science 2015 348 aaa215110.1126/science.aaa2151508850325883361Search in Google Scholar

[8]Driskell R.R., Jahoda C.A., Chuong C.M., Watt F.M., Horsley V.: Defining dermal adipose tissue. Exp. Dermatol., 2014; 23: 629631 Driskell R.R. Jahoda C.A. Chuong C.M. Watt F.M. Horsley V. Defining dermal adipose tissue Exp. Dermatol 2014 23 62963110.1111/exd.12450428270124841073Search in Google Scholar

[9]Schmidt B.A., Horsley V.: Intradermal adipocytes mediate fibroblast recruitment during skin wound healing. Development, 2013; 140: 1517-1527 Schmidt B.A. Horsley V. Intradermal adipocytes mediate fibroblast recruitment during skin wound healing Development 2013 140 1517 152710.1242/dev.087593359699323482487Search in Google Scholar

[10]Walendzik K., Kopcewicz M., Bukowska J., Panasiewicz G., Szafranska B., Gawronska-Kozak B.: The transcription factor FOXN1 regulates skin adipogenesis and affects susceptibility to diet-induced obesity. J. Invest. Dermatol., 2020; 140: 1166-1175.e9 Walendzik K. Kopcewicz M. Bukowska J. Panasiewicz G. Szafranska B. Gawronska-Kozak B. The transcription factor FOXN1 regulates skin adipogenesis and affects susceptibility to diet-induced obesity J. Invest. Dermatol 2020 140 1166 117510.1016/j.jid.2019.11.01031811821Search in Google Scholar

[11]Wojciechowicz K., Gledhill K., Ambler C.A., Manning C.B., Jahoda C.A.: Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4. PLoS One, 2013; 8: e59811 Wojciechowicz K. Gledhill K. Ambler C.A. Manning C.B. Jahoda C.A. Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4 PLoS One 2013 8 e5981110.1371/journal.pone.0059811360855123555789Search in Google Scholar

[12]Schäfer M., Werner S.: Transcriptional control of wound repair. Annu. Rev. Cell. Dev. Biol., 2007; 23: 69-92 Schäfer M. Werner S. Transcriptional control of wound repair Annu. Rev. Cell. Dev. Biol 2007 23 69 9210.1146/annurev.cellbio.23.090506.12360917474876Search in Google Scholar

[13]Arnoux V., Côme C., Kusewitt D.F., Hudson L.G., Savagner P.: Cutaneous wound reepithelialization. W: Rise and Fall of Epithelial Phenotype. Molecular Biology Intelligence Unit, red.: P. Savanger. Springer, Boston (MA) 2005, 111-134 Arnoux V. Côme C. Kusewitt D.F. Hudson L.G. Savagner P. Cutaneous wound reepithelialization W: Rise and Fall of Epithelial Phenotype. Molecular Biology Intelligence Unit, red Savanger P. Springer Boston (MA) 2005 111 13410.1007/0-387-28671-3_8Search in Google Scholar

[14]Safferling K., Sütterlin T., Westphal K., Ernst C., Breuhahn K., James M., Jäger D., Halama N., Grabe N.: Wound healing revised: A novel reepithelialization mechanism revealed by in vitro and in silico models. J. Cell Biol., 2013; 203: 691-709 Safferling K. Sütterlin T. Westphal K. Ernst C. Breuhahn K. James M. Jäger D. Halama N. Grabe N. Wound healing revised: A novel reepithelialization mechanism revealed by in vitro and in silico models J. Cell Biol 2013 203 691 70910.1083/jcb.201212020384093224385489Search in Google Scholar

[15]Chaponnier C., Desmoulière A., Gabbiani G.: Tissue Repair, Contraction and the Myofibroblast. Biotechnology Intelligence Unit. Springer, Boston (MA) 2006 Chaponnier C. Desmoulière A. Gabbiani G. Tissue Repair, Contraction and the Myofibroblast Biotechnology Intelligence Unit Springer Boston (MA) 200610.1007/0-387-33650-8Search in Google Scholar

[16]Gurtner G.C., Werner S., Barrandon Y., Longaker M.T.: Wound repair and regeneration. Nature, 2008; 453: 314-321 Gurtner G.C. Werner S. Barrandon Y. Longaker M.T. Wound repair and regeneration Nature 2008 453 314 32110.1038/nature0703918480812Search in Google Scholar

[17]Singer A.J., Clark R.A.: Cutaneous wound healing. N. Engl. J. Med., 1999; 341: 738-746 Singer A.J. Clark R.A. Cutaneous wound healing N. Engl. J. Med 1999 341 738 74610.1056/NEJM19990902341100610471461Search in Google Scholar

[18]Werner S., Grose R.: Regulation of wound healing by growth factors and cytokines. Physiol. Rev., 2003; 83: 835-870 Werner S. Grose R. Regulation of wound healing by growth factors and cytokines Physiol. Rev 2003 83 835 87010.1152/physrev.2003.83.3.83512843410Search in Google Scholar

[19]Lokmic Z., Musyoka J., Hewitson T.D., Darby I.A.: Hypoxia and hypoxia signaling in tissue repair and fibrosis. Int. Rev. Cell Mol. Biol., 2012; 296: 139-185 Lokmic Z. Musyoka J. Hewitson T.D. Darby I.A. Hypoxia and hypoxia signaling in tissue repair and fibrosis Int. Rev. Cell Mol. Biol 2012 296 139 18510.1016/B978-0-12-394307-1.00003-522559939Search in Google Scholar

[20]Gawronska-Kozak B., Grabowska A., Kur-Piotrowska A., Kopcewicz M.: Foxn1 transcription factor regulates wound healing of skin through promoting epithelial-mesenchymal transition. PLoS One, 2016; 11: e0150635 Gawronska-Kozak B. Grabowska A. Kur-Piotrowska A. Kopcewicz M. Foxn1 transcription factor regulates wound healing of skin through promoting epithelial-mesenchymal transition PLoS One 2016 11 e015063510.1371/journal.pone.0150635477729926938103Search in Google Scholar

[21]Haensel D., Sun P., MacLean A.L., Ma X., Zhou Y., Stemmler M.P., Brabletz S., Berx G., Plikus M.V., Nie Q., Brabletz T., Dai X.: An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation. EMBO Rep., 2019; 20: e46273 Haensel D. Sun P. MacLean A.L. Ma X. Zhou Y. Stemmler M.P. Brabletz S. Berx G. Plikus M.V. Nie Q. Brabletz T. Dai X. An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation EMBO Rep 2019 20 e4627310.15252/embr.201846273632238530413481Search in Google Scholar

[22]Rajendran N.K., Dhilip Kumar S.S., Houreld N.N., Abrahamse H.: Understanding the perspectives of forkhead transcription factors in delayed wound healing. J. Cell Commun. Signal., 2019; 13: 151-162 Rajendran N.K. Dhilip Kumar S.S. Houreld N.N. Abrahamse H. Understanding the perspectives of forkhead transcription factors in delayed wound healing J. Cell Commun. Signal 2019 13 151 16210.1007/s12079-018-0484-0649830030088222Search in Google Scholar

[23]Bellavia G., Fasanaro P., Melchionna R., Capogrossi M.C., Napolitano M.: Transcriptional control of skin reepithelialization. J. Dermatol. Sci., 2014; 73: 3-9 Bellavia G. Fasanaro P. Melchionna R. Capogrossi M.C. Napolitano M. Transcriptional control of skin reepithelialization J. Dermatol. Sci 2014 73 3 910.1016/j.jdermsci.2013.08.00724012494Search in Google Scholar

[24]Lee B., Villarreal-Ponce A., Fallahi M., Ovadia J., Sun P., Yu Q.C., Ito S., Sinha S., Nie Q., Dai X.: Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev. Cell, 2014; 29: 47-58 Lee B. Villarreal-Ponce A. Fallahi M. Ovadia J. Sun P. Yu Q.C. Ito S. Sinha S. Nie Q. Dai X. Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells Dev. Cell 2014 29 47 5810.1016/j.devcel.2014.03.005415375124735878Search in Google Scholar

[25]Mori R., Tanaka K., de Kerckhove M., Okamoto M., Kashiyama K., Tanaka K., Kim S., Kawata T., Komatsu T., Park S. i wsp.: Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring. Am. J. Pathol., 2014; 184: 2465-2479 Mori R. Tanaka K. de Kerckhove M. Okamoto M. Kashiyama K. Tanaka K. Kim S. Kawata T. Komatsu T. Park S. i wsp Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring Am. J. Pathol 2014 184 2465 247910.1016/j.ajpath.2014.05.012418827925010393Search in Google Scholar

[26]Teng A., Nair M., Wells J., Segre J.A., Dai X.: Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis. Biochim. Biophys. Acta, 2007; 1772: 89-95 Teng A. Nair M. Wells J. Segre J.A. Dai X. Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis Biochim. Biophys. Acta 2007 1772 89 9510.1016/j.bbadis.2006.08.012177300417049212Search in Google Scholar

[27]Rowlatt U.: Cleft lip and palate associated with amniotic band limb amputations in a 20 week human fetus. Cleft. Palate. J., 1979; 16: 206-209 Rowlatt U. Cleft lip and palate associated with amniotic band limb amputations in a 20 week human fetus Cleft. Palate. J 1979 16 206 209Search in Google Scholar

[28]Lorenz H.P., Longaker M.T., Perkocha L.A., Jennings R.W., Harrison M.R., Adzick N.S.: Scarless wound repair: A human fetal skin model. Development, 1992; 114: 253-259 Lorenz H.P. Longaker M.T. Perkocha L.A. Jennings R.W. Harrison M.R. Adzick N.S. Scarless wound repair: A human fetal skin model Development 1992 114 253 25910.1242/dev.114.1.2531576963Search in Google Scholar

[29]Ihara S., Motobayashi Y., Nagao E., Kistler A.: Ontogenetic transition of wound healing pattern in rat skin occurring at the fetal stage. Development, 1990; 110: 671-680 Ihara S. Motobayashi Y. Nagao E. Kistler A. Ontogenetic transition of wound healing pattern in rat skin occurring at the fetal stage Development 1990 110 671 68010.1242/dev.110.3.6712088714Search in Google Scholar

[30]Lo D.D., Zimmermann A.S., Nauta A., Longaker M.T., Lorenz H.P.: Scarless fetal skin wound healing update. Birth Defects Res. C. Embryo Today, 2012; 96: 237-247 Lo D.D. Zimmermann A.S. Nauta A. Longaker M.T. Lorenz H.P. Scarless fetal skin wound healing update Birth Defects Res. C. Embryo Today 2012 96 237 24710.1002/bdrc.2101823109319Search in Google Scholar

[31]Chen W., Fu X., Ge S., Sun T., Zhou G., Jiang D., Sheng Z.: Ontogeny of expression of transforming growth factor-β and its receptors and their possible relationship with scarless healing in human fetal skin. Wound Repair Regen., 2005; 13: 68-75 Chen W. Fu X. Ge S. Sun T. Zhou G. Jiang D. Sheng Z. Ontogeny of expression of transforming growth factor-β and its receptors and their possible relationship with scarless healing in human fetal skin Wound Repair Regen 2005 13 68 7510.1111/j.1067-1927.2005.130109.x15659038Search in Google Scholar

[32]Kishi K., Okabe K., Shimizu R., Kubota Y.: Fetal skin possesses the ability to regenerate completely: Complete regeneration of skin. Keio J. Med., 2012; 61: 101-108 Kishi K. Okabe K. Shimizu R. Kubota Y. Fetal skin possesses the ability to regenerate completely: Complete regeneration of skin Keio J. Med 2012 61 101 10810.2302/kjm.2011-0002-IRSearch in Google Scholar

[33]Gawronska-Kozak B.: Regeneration in the ears of immunodeficient mice: Identification and lineage analysis of mesenchymal stem cells. Tissue Eng., 2004; 10: 1251-1265 Gawronska-Kozak B. Regeneration in the ears of immunodeficient mice: Identification and lineage analysis of mesenchymal stem cells Tissue Eng 2004 10 1251 126510.1089/ten.2004.10.125115363180Search in Google Scholar

[34]Gawronska-Kozak B.: Scarless skin wound healing in FOXN1 deficient (nude) mice is associated with distinctive matrix metalloproteinase expression. Matrix Biol., 2011; 30: 290-300 Gawronska-Kozak B. Scarless skin wound healing in FOXN1 deficient (nude) mice is associated with distinctive matrix metalloproteinase expression Matrix Biol 2011 30 290 30010.1016/j.matbio.2011.04.004311418321539913Search in Google Scholar

[35]Gawronska-Kozak B., Bogacki M., Rim J.S., Monroe W.T., Manuel J.A.: Scarless skin repair in immunodeficient mice. Wound Repair. Regen., 2006; 14: 265-276 Gawronska-Kozak B. Bogacki M. Rim J.S. Monroe W.T. Manuel J.A. Scarless skin repair in immunodeficient mice Wound Repair. Regen 2006 14 265 27610.1111/j.1743-6109.2006.00121.x16808805Search in Google Scholar

[36]Brant J.O., Yoon J.H., Polvadore T., Barbazuk W.B., Maden M.: Cellular events during scar-free skin regeneration in the spiny mouse, Acomys. Wound Repair Regen., 2016; 24:. 75-88 Brant J.O. Yoon J.H. Polvadore T. Barbazuk W.B. Maden M. Cellular events during scar-free skin regeneration in the spiny mouse, Acomys Wound Repair Regen 2016 24 75 8810.1111/wrr.1238526606280Search in Google Scholar

[37]Seifert A.W., Kiama S.G., Seifert M.G., Goheen J.R., Palmer T.M., Maden M.: Skin shedding and tissue regeneration in African spiny mice (Acomys). Nature, 2012; 489: 561-565 Seifert A.W. Kiama S.G. Seifert M.G. Goheen J.R. Palmer T.M. Maden M. Skin shedding and tissue regeneration in African spiny mice (Acomys) Nature 2012 489 561 56510.1038/nature11499348008223018966Search in Google Scholar

[38]Boehm T., Swann J.B.: Thymus involution and regeneration: Two sides of the same coin? Nat. Rev. Immunol. 2013; 13: 831-838 Boehm T. Swann J.B. Thymus involution and regeneration: Two sides of the same coin? Nat Rev. Immunol 2013 13 831 83810.1038/nri353424052146Search in Google Scholar

[39]Schlake T.: The nude gene and the skin. Exp Dermatol, 2001; 10: 293-304 Schlake T. The nude gene and the skin Exp Dermatol 2001 10 293 30410.1034/j.1600-0625.2001.100501.x11589726Search in Google Scholar

[40]Mecklenburg L., Tychsen B., Paus R.: Learning from nudity: Lessons from the nude phenotype. Exp. Dermatol., 2005; 14: 797-810 Mecklenburg L. Tychsen B. Paus R. Learning from nudity: Lessons from the nude phenotype Exp. Dermatol 2005 14 797 81010.1111/j.1600-0625.2005.00362.x16232301Search in Google Scholar

[41]Flanagan S.P.: ‘Nude’, a new hairless gene with pleiotropic effects in the mouse. Genet. Res., 1966; 8: 295-309 Flanagan S.P. ‘Nude’, a new hairless gene with pleiotropic effects in the mouse Genet. Res 1966 8 295 30910.1017/S00166723000101685980117Search in Google Scholar

[42]Gawronska B., Leuschner C., Enright F.M., Hansel W.: Effects of a lytic peptide conjugated to β HCG on ovarian cancer: Studies in vitro and in vivo. Gynecol. Oncol., 2002; 85: 45-52 Gawronska B. Leuschner C. Enright F.M. Hansel W. Effects of a lytic peptide conjugated to β HCG on ovarian cancer: Studies in vitro and in vivo Gynecol. Oncol 2002 85 45 5210.1006/gyno.2001.655811925119Search in Google Scholar

[43]Kopcewicz M.M., Kur-Piotrowska A., Bukowska J., Gimble J.M., Gawronska-Kozak B.: Foxn1 and Mmp-9 expression in intact skin and during excisional wound repair in young, adult, and old C57Bl/6 mice. Wound Repair Regen., 2017; 25: 248-259 Kopcewicz M.M. Kur-Piotrowska A. Bukowska J. Gimble J.M. Gawronska-Kozak B. Foxn1 and Mmp-9 expression in intact skin and during excisional wound repair in young, adult, and old C57Bl/6 mice Wound Repair Regen 2017 25 248 25910.1111/wrr.1252428371152Search in Google Scholar

[44]Bukowska J., Kopcewicz M., Walendzik K., Gawronska-Kozak B.: Foxn1 in skin development, homeostasis and wound healing. Int. J. Mol. Sci., 2018; 19: 1956 Bukowska J. Kopcewicz M. Walendzik K. Gawronska-Kozak B. Foxn1 in skin development, homeostasis and wound healing Int. J. Mol. Sci 2018 19 195610.3390/ijms19071956607367429973508Search in Google Scholar

[45]Lee D., Prowse D.M., Brissette J.L.: Association between mouse nude gene expression and the initiation of epithelial terminal differentiation. Dev. Biol., 1999; 208: 362-374 Lee D. Prowse D.M. Brissette J.L. Association between mouse nude gene expression and the initiation of epithelial terminal differentiation Dev. Biol 1999 208 362 37410.1006/dbio.1999.922110191051Search in Google Scholar

[46]Baxter R.M., Brissette J.L.: Role of the nude gene in epithelial terminal differentiation. J. Invest. Dermatol., 2002; 118: 303-309 Baxter R.M. Brissette J.L. Role of the nude gene in epithelial terminal differentiation J. Invest. Dermatol 2002 118 303 30910.1046/j.0022-202x.2001.01662.x11841548Search in Google Scholar

[47]Brissette J.L., Li J., Kamimura J., Lee D., Dotto G.P.: The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation. Genes Dev., 1996; 10: 2212-2221 Brissette J.L. Li J. Kamimura J. Lee D. Dotto G.P. The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation Genes Dev 1996 10 2212 222110.1101/gad.10.17.22128804315Search in Google Scholar

[48]Prowse D.M., Lee D., Weiner L., Jiang N., Magro C.M., Baden H.P., Brissette J.L.: Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation: Implications for the self-renewal of cutaneous epithelia. Dev. Biol., 1999; 212: 54-67 Prowse D.M. Lee D. Weiner L. Jiang N. Magro C.M. Baden H.P. Brissette J.L. Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation: Implications for the self-renewal of cutaneous epithelia Dev. Biol 1999 212 54 6710.1006/dbio.1999.932810419685Search in Google Scholar

[49]Li J., Baxter R.M., Weiner L., Goetinck P.F., Calautti E., Brissette J.L.: Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C. Differentiation, 2007; 75: 694-701 Li J. Baxter R.M. Weiner L. Goetinck P.F. Calautti E. Brissette J.L. Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C Differentiation 2007 75 694 70110.1111/j.1432-0436.2007.00176.x17459087Search in Google Scholar

[50]Calautti E., Li J., Saoncella S., Brissette J.L., Goetinck P.F.: Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death. J. Biol. Chem., 2005; 280: 32856-32865 Calautti E. Li J. Saoncella S. Brissette J.L. Goetinck P.F. Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death J. Biol. Chem 2005 280 32856 3286510.1074/jbc.M50611920016036919Search in Google Scholar

[51]Janes S.M., Ofstad T.A., Campbell D.H., Eddaoudi A., Warnes G., Davies D.,Watt F.M.: PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation. Cell Res., 2009; 19: 328-339 Janes S.M. Ofstad T.A. Campbell D.H. Eddaoudi A. Warnes G. Davies D.Watt F.M. PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation Cell Res 2009 19 328 33910.1038/cr.2008.281265068418766172Search in Google Scholar

[52]Janes S.M., Ofstad T.A., Campbell D.H., Watt F.M., Prowse D.M.: Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: Contrasting roles of FOXN1 and Akt. J. Cell. Sci., 2004; 117: 4157-4168 Janes S.M. Ofstad T.A. Campbell D.H. Watt F.M. Prowse D.M. Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: Contrasting roles of FOXN1 and Akt J. Cell. Sci 2004 117 4157 416810.1242/jcs.0130215316080Search in Google Scholar

[53]Kur-Piotrowska A., Bukowska J., Kopcewicz M.M., Dietrich M., Nynca J., Slowinska M., Gawronska-Kozak B.: Foxn1 expression in keratinocytes is stimulated by hypoxia: Further evidence of its role in skin wound healing. Sci. Rep., 2018; 8: 5425 Kur-Piotrowska A. Bukowska J. Kopcewicz M.M. Dietrich M. Nynca J. Slowinska M. Gawronska-Kozak B. Foxn1 expression in keratinocytes is stimulated by hypoxia: Further evidence of its role in skin wound healing Sci. Rep 2018 8 542510.1038/s41598-018-23794-5Search in Google Scholar

[54]Weiner L., Han R., Scicchitano B.M., Li J., Hasegawa K., Grossi M., Lee D., Brissette J.L.: Dedicated epithelial recipient cells determine pigmentation patterns. Cell, 2007; 130: 932-942 Weiner L. Han R. Scicchitano B.M. Li J. Hasegawa K. Grossi M. Lee D. Brissette J.L. Dedicated epithelial recipient cells determine pigmentation patterns Cell 2007 130 932 94210.1016/j.cell.2007.07.024Search in Google Scholar

[55]Meier N., Dear T.N., Boehm T.: Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation. Mech. Dev., 1999; 89: 215-221 Meier N. Dear T.N. Boehm T. Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation Mech. Dev 1999 89 215 22110.1016/S0925-4773(99)00218-XSearch in Google Scholar

[56]Schlake T., Schorpp M., Maul-Pavicic A., Malashenko A.M., Boehm T.: Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: Molecular analysis of the nude skin phenotype. Dev. Dyn., 2000; 217: 368-376 Schlake T. Schorpp M. Maul-Pavicic A. Malashenko A.M. Boehm T. Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: Molecular analysis of the nude skin phenotype Dev. Dyn 2000 217 368 37610.1002/(SICI)1097-0177(200004)217:4<368::AID-DVDY4>3.0.CO;2-ZSearch in Google Scholar

[57]Schlake T., Schorpp M., Nehls M., Boehm T.: The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system. Proc. Natl. Acad. Sci. USA, 1997; 94: 3842-3847 Schlake T. Schorpp M. Nehls M. Boehm T. The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system Proc. Natl. Acad. Sci. USA 1997 94 3842 384710.1073/pnas.94.8.3842Search in Google Scholar

[58]Pignata C., Fiore M., Guzzetta V., Castaldo A., Sebastio G., Porta F., Guarino A.: Congenital alopecia and nail dystrophy associated with severe functional T-cell immunodeficiency in two sibs. Am. J. Med. Genet., 1996; 65: 167-170 Pignata C. Fiore M. Guzzetta V. Castaldo A. Sebastio G. Porta F. Guarino A. Congenital alopecia and nail dystrophy associated with severe functional T-cell immunodeficiency in two sibs Am. J. Med. Genet 1996 65 167 17010.1002/(SICI)1096-8628(19961016)65:2<167::AID-AJMG17>3.0.CO;2-OSearch in Google Scholar

[59]Mecklenburg L., Nakamura M., Sundberg J.P., Paus R.: The nude mouse skin phenotype: The role of Foxn1 in hair follicle development and cycling. Exp. Mol. Pathol., 2001; 71: 171-178 Mecklenburg L. Nakamura M. Sundberg J.P. Paus R. The nude mouse skin phenotype: The role of Foxn1 in hair follicle development and cycling Exp. Mol. Pathol 2001 71 171 17810.1006/exmp.2001.2386Search in Google Scholar

[60]Kur-Piotrowska A., Kopcewicz M., Kozak L.P., Sachadyn P., Grabowska A., Gawronska-Kozak B.: Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice – a projection for regenerative skin wound healing. BMC Genomics, 2017; 18: 56 Kur-Piotrowska A. Kopcewicz M. Kozak L.P. Sachadyn P. Grabowska A. Gawronska-Kozak B. Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice – a projection for regenerative skin wound healing BMC Genomics 2017 18 5610.1186/s12864-016-3401-zSearch in Google Scholar

[61]Sousounis K., Michel C.S., Bruckskotten M., Maki N., Borchardt T., Braun T., Looso M., Tsonis P.A.: A microarray analysis of gene expression patterns during early phases of newt lens regeneration. Mol. Vis., 2013; 19: 135-145 Sousounis K. Michel C.S. Bruckskotten M. Maki N. Borchardt T. Braun T. Looso M. Tsonis P.A. A microarray analysis of gene expression patterns during early phases of newt lens regeneration Mol. Vis 2013 19 135 145Search in Google Scholar

[62]Heydemann A.: The super super-healing MRL mouse strain. Front. Biol., 2012; 7: 522-538 Heydemann A. The super super-healing MRL mouse strain Front. Biol 2012 7 522 53810.1007/s11515-012-1192-4Search in Google Scholar

[63]Bukowska J., Walendzik K., Kopcewicz M., Cierniak P., Gawronska-Kozak B.: Wnt signaling and the transcription factor Foxn1 contribute to cutaneous wound repair in mice. Connect. Tissue Res., 2021; 62: 238-248 Bukowska J. Walendzik K. Kopcewicz M. Cierniak P. Gawronska-Kozak B. Wnt signaling and the transcription factor Foxn1 contribute to cutaneous wound repair in mice Connect. Tissue Res 2021 62 238 24810.1080/03008207.2019.1688314Search in Google Scholar

[64]Bukowska J., Kopcewicz M., Kur-Piotrowska A., Szostek-Mioduchowska A.Z., Walendzik K., Gawronska-Kozak B.: Effect of TGFβ1, TGFβ3 and keratinocyte conditioned media on functional characteristics of dermal fibroblasts derived from reparative (Balb/c) and regenerative (Foxn1 deficient; nude) mouse models. Cell Tissue Res., 2018; 374: 149-163 Bukowska J. Kopcewicz M. Kur-Piotrowska A. Szostek-Mioduchowska A.Z. Walendzik K. Gawronska-Kozak B. Effect of TGFβ1, TGFβ3 and keratinocyte conditioned media on functional characteristics of dermal fibroblasts derived from reparative (Balb/c) and regenerative (Foxn1 deficient; nude) mouse models Cell Tissue Res 2018 374 149 16310.1007/s00441-018-2836-8613264729637306Search in Google Scholar

[65]Gawronska-Kozak B., Kirk-Ballard H.: Cyclosporin A reduces matrix metalloproteinases and collagen expression in dermal fibroblasts from regenerative FOXN1 deficient (nude) mice. Fibrog. Tissue Repair, 2013; 6: 7 Gawronska-Kozak B. Kirk-Ballard H. Cyclosporin A reduces matrix metalloproteinases and collagen expression in dermal fibroblasts from regenerative FOXN1 deficient (nude) mice Fibrog. Tissue Repair 2013 6 710.1186/1755-1536-6-7363747523547542Search in Google Scholar

[66]Stemmer K., Kotzbeck P., Zani F., Bauer M., Neff C., Müller T.D., Pfluger P.T., Seeley R.J., Divanovic S.: Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice. Int. J. Obes., 2015; 39: 791-797 Stemmer K. Kotzbeck P. Zani F. Bauer M. Neff C. Müller T.D. Pfluger P.T. Seeley R.J. Divanovic S. Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice Int. J. Obes 2015 39 791 79710.1038/ijo.2014.187441275925349057Search in Google Scholar

[67]Donati G., Proserpio V., Lichtenberger B.M., Natsuga K., Sinclair R., Fujiwara H.,Watt F.M.: Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors. Proc. Natl. Acad. Sci. USA, 2014; 111: E1501-E1509 Donati G. Proserpio V. Lichtenberger B.M. Natsuga K. Sinclair R. Fujiwara H.Watt F.M. Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors Proc. Natl. Acad. Sci. USA 2014 111 E1501 E150910.1073/pnas.1312880111399265724706781Search in Google Scholar

[68]Lanzini J., Dargère D., Regazzetti A., Tebani A., Laprévote O., Auzeil N.: Changing in lipid profile induced by the mutation of Foxn1 gene: A lipidomic analysis of Nude mice skin. Biochimie, 2015; 118: 234-243 Lanzini J. Dargère D. Regazzetti A. Tebani A. Laprévote O. Auzeil N. Changing in lipid profile induced by the mutation of Foxn1 gene: A lipidomic analysis of Nude mice skin Biochimie 2015 118 234 24310.1016/j.biochi.2015.09.02926427556Search in Google Scholar