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European Pharmaceutical Journal
Volume 70 (2023): Numero 1 (December 2023)
Accesso libero
Experimental evaluation of the nonselective and selective TMEM16 family calcium-activated chloride channel blockers in the airways
J. Mažerik
J. Mažerik
,
L. Smieško
L. Smieško
,
L. Fedorová
L. Fedorová
e
E. Gondáš
E. Gondáš
| 30 set 2023
European Pharmaceutical Journal
Volume 70 (2023): Numero 1 (December 2023)
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Article Category:
Original Paper
Pubblicato online:
30 set 2023
Pagine:
1 - 7
Ricevuto:
19 mag 2023
Accettato:
14 ago 2023
DOI:
https://doi.org/10.2478/afpuc-2023-0016
Parole chiave
calcium-activated chloride channels
,
TMEM16A channel
,
cough reflex
,
bronchoconstriction
,
mucociliary clearance
,
guinea pigs
© 2023 J. Mažerik et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1.
Comparison of the changes in the number of AC-induced coughs by OVA sensitization and different treatments. Tested drugs were administered by inhalation (A, B) or intraperitoneally (C, D). The measurements of response on the inhalation of substances were performed after 60 and 120 min, and the effect when they were administered intraperitoneally was evaluated after 60 and 240 min. For the statistical analysis, one-way ANOVA and Bonferroni post hoc test were used.*p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001 versus negative control group (saline); +p ≤ 0.05, ++p ≤ 0.01, and +++p ≤ 0.001 negative control group versus positive control group (codeine).
Figure 2.
Comparison of sRaw values in healthy OVA-sensitized guinea pigs treated with TMEM16 blockers and control drugs when challenged with inhalational histamine and methacholine. The substances were administered by inhalation or intraperitoneally.#p ≤ 0.05 versus salbutamol; for further explanation of statistical analysis, see legend to Fig. 1.
Figure 3.
Results of CBF analysis. The changes in values were monitored on samples obtained from healthy and OVA-sensitized, untreated animals and 100 μl of substances was administered directly to the samples in the same concentration that was used for inhalation. B-benzbromarone, A01-CaCCinh-A01, OVAS-negative control saline tested in sensitized airways, OVAB-benzbromarone tested in sensitized airways, and OVAA01-CaCCinh-A01 tested in sensitized airways. */+ p ≤ 0.05, one-way ANOVA and Bonferroni posthoc test.