Accesso libero

Effect of Saffron Extract, Astaxanthin, and Carnosic Acid on the Levels of Matrix Metalloproteinase-9 and on Body Weight Changes in Arthritis Experiments

M Chrastina

M Chrastina

  • Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of SciencesBratislava, Slovakia
  • Jessenius Faculty of Medicine in Martin, Department of Pharmacology, Comenius University in BratislavaMartin, Slovakia
Cerca questo autore su
Sciendo|Google Scholar
Chrastina, M
, 
S Póništ

S Póništ

Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of SciencesBratislava, Slovakia
Cerca questo autore su
Sciendo|Google Scholar
Póništ, S
, 
F Dráfi

F Dráfi

Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of SciencesBratislava, Slovakia
Cerca questo autore su
Sciendo|Google Scholar
Dráfi, F
, 
K Švík

K Švík

Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of SciencesBratislava, Slovakia
Cerca questo autore su
Sciendo|Google Scholar
Švík, K
, 
S Khademnematolahi

S Khademnematolahi

  • Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of SciencesBratislava, Slovakia
  • Faculty of Natural Sciences, Department of Animal Physiology and Ethology, Comenius University in BratislavaBratislava, Slovakia
Cerca questo autore su
Sciendo|Google Scholar
Khademnematolahi, S
, 
K Pružinská

K Pružinská

  • Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of SciencesBratislava, Slovakia
  • Jessenius Faculty of Medicine in Martin, Department of Pharmacology, Comenius University in BratislavaMartin, Slovakia
Cerca questo autore su
Sciendo|Google Scholar
Pružinská, K
, 
A Tchorbanov

A Tchorbanov

The Stephan Angeloff Institute of Microbiology (SAIM), Bulgarian Academy of SciencesSofia, Bulgaria
Cerca questo autore su
Sciendo|Google Scholar
Tchorbanov, A
 e 
K Bauerová

K Bauerová

Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of SciencesBratislava, Slovakia
Cerca questo autore su
Sciendo|Google Scholar
Bauerová, K
  
03 mar 2023
Effect of Saffron Extract, Astaxanthin, and Carnosic Acid on the Levels of Matrix Metalloproteinase-9 and on Body Weight Changes in Arthritis Experiments's Cover Image
INFORMAZIONI SU QUESTO ARTICOLO
Articolo precedente
Articolo Successivo
Cita
Scarica la copertina
Categoria dell'articolo: Original Paper
Pubblicato online: 03 mar 2023
Pagine: 26 - 33
Ricevuto: 15 feb 2022
Accettato: 05 ott 2022
DOI: https://doi.org/10.2478/afpuc-2022-0016
Parole chiave
© 2022 Martin C et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Extract of Crocus sativus: Change of body weight and levels of MMP-9 in plasma (x: HC vs. AA, *: AA vs. treated groups).
Extract of Crocus sativus: Change of body weight and levels of MMP-9 in plasma (x: HC vs. AA, *: AA vs. treated groups).

Figure 2

Astaxanthin: Change of body weight and levels of MMP-9 in plasma (x: HC vs. AA, *: AA vs. treated groups).
Astaxanthin: Change of body weight and levels of MMP-9 in plasma (x: HC vs. AA, *: AA vs. treated groups).

Figure 3

Carnosic acid: Change of body weight and levels of MMP-9 in plasma (x: HC vs. AA, *: AA vs. treated groups).
Carnosic acid: Change of body weight and levels of MMP-9 in plasma (x: HC vs. AA, *: AA vs. treated groups).

Summary of experimental design of three different experiments (a, b, and c)_

Group Treatment Peroral dose
Group 1 a, b, c: healthy controls (HC) Vehiculum 0.5 ml daily
Group 2 a, b, c: adjuvant arthritis (AA) untreated Vehiculum 0.5 ml daily
Group 3 a, b, c: AA + treatment Methotrexate (M) 0.3 mg/kg twice a week
Group 4 a: AA + treatment Saffron extract (SF1) 25 mg/kg daily
Group 5 a: AA + treatment Saffron extract (SF2) 50 mg/kg daily
Group 6 a: AA + treatment SF1+ M 25 mg/kg + 0.3 mg/kg
Group 7 a: AA + treatment SF2 + M 50 mg/kg + 0.3 mg/kg
Group 4 b: AA + treatment Astaxanthin (AS1) 1 mg/kg daily
Group 5 b: AA + treatment Astaxanthin (AS2) 5 mg/kg daily
Group 4 c: AA + treatment Carnosic acid (C) 100 mg/kg daily
Group 5 c: AA + treatment C + M 100 mg/kg + 0.3 mg/kg
Lingua:
Inglese
Frequenza di pubblicazione:
2 volte all'anno
Argomenti della rivista:
Farmacia, Farmacia, altro
Feed RSS della rivista