[
1. Herrmann K, Flecknell P: Severity classification of surgical procedures and application of health monitoring strategies in animal research proposals: A retrospective review. Altern to Lab Anim 2018, 46:273–89.10.1177/026119291804600508
]Search in Google Scholar
[
2. Aghashani A, Verstraete FJM, Arzi B: Temporomandibular joint gap arthroplasty in cats. Front Vet Sci 2020, 7.10.3389/fvets.2020.00482743872332903530
]Search in Google Scholar
[
3. Selting KA, Lattimer JC, Hause W, Megan G: Osteochondrodysplasia in a Scottish Fold cat treated with radiation therapy and samarium-153-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetramethylene-phosphonic acid. J Am Anim Hosp Assoc 2019, 55.10.5326/JAAHA-MS-679730870611
]Search in Google Scholar
[
4. Reimann J, Dewey C, Bateman SW, Kerr C, Johnson R: Perioperative analgesic use by Ontario veterinarians, 2012. Can Vet J 2017, 58:149.
]Search in Google Scholar
[
5. Ugwu NE, Eze CA, Udegbunam RI, Nnaji TO: Perioperative analgesic efficacy of constant rate infused tramadol hydrochloride as an adjunct to postoperative ketoprofen in ovariohysterectomized bitches. Indian J Anim Res 2020, 54:627–30.
]Search in Google Scholar
[
6. Donati PA, Tarragona L, Franco JVA, Kreil V, Fravega R, Diaz A, Verdier N, Otero PE: Efficacy of tramadol for postoperative pain management in dogs: systematic review and meta-analysis. Vet Anaesth Analg 2021, 48:283–96.10.1016/j.vaa.2021.01.00333745825
]Search in Google Scholar
[
7. Jimenez TEP, Kukanich B, Joo H, Mealey KL, Grubb TL, Greene SA: Oral coadministration of fluconazole with tramadol markedly increases plasma and urine concentrations of tramadol and the O-desmethyltramadol metabolite in healthy dogs. Drug Metab Dispos 2019, 47:15–25.10.1124/dmd.118.083444629008230366901
]Search in Google Scholar
[
8. Teixeira LG, Martins LR, Schimites PI, Dornelles GL, Aiello G, Oliveira JS, da Silva FC, Brum BTS, Walter TMC, Andrade CM: Evaluation of postoperative pain and toxicological aspects of the use of dipyrone and tramadol in cats. J Feline Med Surg 2020, 22:467–75.10.1177/1098612X1984996931112057
]Search in Google Scholar
[
9. Doostmohammadi M, Rahimi H-R: ADME and toxicity considerations for tramadol: from basic research to clinical implications. Expert Opin Drug Metab Toxicol 2020, 16:627–40.10.1080/17425255.2020.177670032476523
]Search in Google Scholar
[
10. Varrassi G, Hanna M, Macheras G, Montero A, Montes Perez A, Meissner W, Perrot S, Scarpignato C: Multimodal analgesia in moderate-to-severe pain: a role for a new fixed combination of dexketoprofen and tramadol. Curr Med Res Opin 2017, 33:1165–73.10.1080/03007995.2017.131009228326850
]Search in Google Scholar
[
11. Tobias KM, Harvey RC, Byarlay JM: A comparison of four methods of analgesia in cats following ovariohysterectomy. Vet Anaesth Analg 2006, 33:390–8.10.1111/j.1467-2995.2005.00282.x17083611
]Search in Google Scholar
[
12. Miotto K, Cho AK, Khalil MA, Blanco K, Sasaki JD, Rawson R: Trends in tramadol: pharmacology, metabolism, and misuse. Anesth Analg 2017, 124:44–51.10.1213/ANE.000000000000168327861439
]Search in Google Scholar
[
13. Umar Y, Abdalla S, Haque SKM, Moran GS, Ishaq A, Villada WC, Leone JD, Bunster M: Theoretical investigation of the molecular structure, vibrational spectra, and molecular docking of tramadol using density functional theory. J Chinese Chem Soc 2020, 67:62–71.10.1002/jccs.201900051
]Search in Google Scholar
[
14. Lorenz ND, Comerford EJ, Iff I: Long-term use of gabapentin for musculoskeletal disease and trauma in three cats. J Feline Med Surg 2013, 15:507–12.10.1177/1098612X1247082823253881
]Search in Google Scholar
[
15. Pankratz KE, Ferris KK, Griffith EH, Sherman BL: Use of single-dose oral gabapentin to attenuate fear responses in cage-trap confined community cats: a double-blind, placebo-controlled field trial. J Feline Med Surg 2018, 20:535–43.10.1177/1098612X1771939928718700
]Search in Google Scholar
[
16. Mao J, Chen LL: Gabapentin in pain management. Anesth Analg 2000, 91:680–7.10.1213/00000539-200009000-00034
]Search in Google Scholar
[
17. Ghafari MH, Akrami M, Nouralishahi B, Sadegh A: Preoperative gabapentin or clonidine decreases postoperative pain and morphine consumption after abdominal hysterectomy. Res J Biol Sci 2009, 4:458–63.
]Search in Google Scholar
[
18. Kukkar A, Bali A, Singh N, Jaggi AS: Implications and mechanism of action of gabapentin in neuropathic pain. Arch Pharm Res 2013, 36:237–51.10.1007/s12272-013-0057-y23435945
]Search in Google Scholar
[
19. Siao KT, Pypendop BH, Ilkiw JE: Pharmacokinetics of gabapentin in cats. Am J Vet Res 2010, 71:817–21.10.2460/ajvr.71.7.81720594085
]Search in Google Scholar
[
20. Goich M, Bascuñán A, Faúndez P, Valdés A: Multimodal analgesia for treatment of allodynia and hyperalgesia after major trauma in a cat. J Feline Med Surg Open Reports 2019, 5:2055116919855809.10.1177/2055116919855809658230331245022
]Search in Google Scholar
[
21. Giudice E, Crinò C, Barillaro G, Crupi R, Macrì F, Viganò F, Di Pietro S: Clinical findings in degenerative lumbosacral stenosis in ten dogs—A pilot study on the analgesic activity of tramadol and gabapentin. J Vet Behav 2019, 33:7–15.10.1016/j.jveb.2019.05.004
]Search in Google Scholar
[
22. Nazifi S, Tabrizi AS, Mohammadi S, Erjaee H, Mirzaie A: The effect of tramadol and meloxicam, alone and in combination on oxidative stress status in dogs. Comp Clin Path 2019, 28:1055–60.10.1007/s00580-019-02927-w
]Search in Google Scholar
[
23. Guedes AGP, Meadows JM, Pypendop BH, Johnson EG, Zaffarano B: Assessment of the effects of gabapentin on activity levels and owner-perceived mobility impairment and quality of life in osteoarthritic geriatric cats. J Am Vet Med Assoc 2018, 253:579–85.10.2460/javma.253.5.57930110208
]Search in Google Scholar
[
24. Nicácio IPGA, Stelle ABF, Bruno TS, Nicácio GM, Costa Jr JS, Cassu RN: Comparison of intraperitoneal ropivacaine and ropivacaine–dexmedetomidine for postoperative analgesia in cats undergoing ovariohysterectomy. Vet Anaesth Analg 2020, 47:396–404.10.1016/j.vaa.2020.01.00732199795
]Search in Google Scholar
[
25. Bhalla RJ, Trimble TA, Leece EA, Vettorato E: Comparison of intramuscular butorphanol and buprenorphine combined with dexmedetomidine for sedation in cats. J Feline Med Surg 2018, 20:325–31.10.1177/1098612X1770961228548551
]Search in Google Scholar
[
26. Benito J, Monteiro BP, Beauchamp G, Lascelles BDX, Steagall P V: Evaluation of interobserver agreement for postoperative pain and sedation assessment in cats. J Am Vet Med Assoc 2017, 251:544–51.10.2460/javma.251.5.54428828950
]Search in Google Scholar
[
27. Slatter DH: Textbook of small animal surgery. 2nd edition. Philadelphia, USA: Elsevier Health Sciences; 2003,.
]Search in Google Scholar
[
28. Brondani JT, Luna LSP, Beier SL, Minto BW, Padovani CR: Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy. J Feline Med Surg 2009, 11:420–9.10.1016/j.jfms.2008.10.00219233698
]Search in Google Scholar
[
29. Brondani JT, Mama KR, Luna SPL, Wright BD, Niyom S, Ambrosio J, Vogel PR, Padovani CR: Validation of the English version of the UNESP-Botucatu multidimensional composite pain scale for assessing postoperative pain in cats. BMC Vet Res 2013, 9:1–15.10.1186/1746-6148-9-143372203223867090
]Search in Google Scholar
[
30. de Sousa MVP, Ferraresi C, de Magalhães AC, Yoshimura EM, Hamblin MR: Building, testing and validating a set of home-made von Frey filaments: A precise, accurate and cost effective alternative for nociception assessment. J Neurosci Methods 2014, 232:1–5.10.1016/j.jneumeth.2014.04.017413663724793398
]Search in Google Scholar
[
31. Van Haaften KA, Forsythe LRE, Stelow EA, Bain MJ: Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination. J Am Vet Med Assoc 2017, 251:1175–81.10.2460/javma.251.10.117529099247
]Search in Google Scholar
[
32. Bradbrook C, Clark L: State of the art analgesia—Recent developments pharmacological approaches to acute pain management in dogs and cats: Part 2. Vet J 2018, 236:62–7.10.1016/j.tvjl.2018.04.00929871752
]Search in Google Scholar
[
33. Arumugam S, Lau CSM, Chamberlain RS: Use of preoperative gabapentin significantly reduces postoperative opioid consumption: a meta-analysis. J Pain Res 2016, 9:631.10.2147/JPR.S112626502621427672340
]Search in Google Scholar
[
34. Alayed N, Alghanaim N, Tan X, Tulandi T: Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstet Gynecol 2014, 123:1221–9.10.1097/AOG.000000000000028924807337
]Search in Google Scholar
[
35. Yu L, Ran B, Li M, Shi Z: Gabapentin and pregabalin in the management of postoperative pain after lumbar spinal surgery: a systematic review and meta-analysis. Spine (Phila Pa 1976) 2013, 38:1947–52.10.1097/BRS.0b013e3182a69b9023921329
]Search in Google Scholar
[
36. Han C, Li X, Jiang H, Ma J, Ma X: The use of gabapentin in the management of postoperative pain after total knee arthroplasty: a PRISMA-compliant meta-analysis of randomized controlled trials. Medicine (Baltimore) 2016, 95:e3883.10.1097/MD.0000000000003883490768127281103
]Search in Google Scholar
[
37. Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J: The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis. Anesth Analg 2012, 115:428–42.10.1213/ANE.0b013e318249d36e22415535
]Search in Google Scholar
[
38. Wagner AE, Mich PM, Uhrig SR, Hellyer PW: Clinical evaluation of perioperative administration of gabapentin as an adjunct for postoperative analgesia in dogs undergoing amputation of a forelimb. J Am Vet Med Assoc 2010, 236:751–6.10.2460/javma.236.7.75120367041
]Search in Google Scholar
[
39. Vettorato E, Corletto F: Gabapentin as part of multi-modal analgesia in two cats suffering multiple injuries. Vet Anaesth Analg 2011, 38:518–20.10.1111/j.1467-2995.2011.00638.x21831060
]Search in Google Scholar
[
40. Ménigaux C, Adam F, Guignard B, Sessler DI, Chauvin M: Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. Anesth Analg 2005, 100:1394.10.1213/01.ANE.0000152010.74739.B8135138215845693
]Search in Google Scholar
[
41. Merola I, Mills DS: Systematic review of the behavioural assessment of pain in cats. J Feline Med Surg 2016, 18:60–76.10.1177/1098612X1557872525972247
]Search in Google Scholar
[
42. Reid J, Scott EM, Calvo G, Nolan AM: Definitive Glasgow acute pain scale for cats: validation and intervention level. Vet Rec 2017, 108.10.1136/vr.10420828130405
]Search in Google Scholar
[
43. Bruera E, Belzile M, Pituskin E, Fainsinger R, Darke A, Harsanyi Z, Babul N, Ford I: Randomized, double-blind, cross-over trial comparing safety and efficacy of oral controlled-release oxycodone with controlled-release morphine in patients with cancer pain. J Clin Oncol 1998, 16:3222–9.10.1200/JCO.1998.16.10.32229779695
]Search in Google Scholar
[
44. Mills DS, Demontigny-Bédard I, Gruen M, Klinck MP, McPeake KJ, Barcelos AM, Hewison L, Van Haevermaet H, Denenberg S, Hauser H: Pain and problem behavior in cats and dogs. Animals 2020, 10:318.10.3390/ani10020318707113432085528
]Search in Google Scholar
[
45. Dobbins S, Brown NO, Shofer FS: Comparison of the effects of buprenorphine, oxymorphone hydrochloride, and ketoprofen for postoperative analgesia after onychectomy or onychectomy and sterilization in cats. J Am Anim Hosp Assoc 2002, 38:507–14.10.5326/0380507
]Search in Google Scholar
[
46. Fox SM, Mellor DJ, Firth EC, Hodge H, Lawoko CRO: Changes in plasma cortisol concentrations before, during and after analgesia, anaesthesia and anaesthesia plus ovariohysterectomy in bitches. Res Vet Sci 1994, 57:110–8.10.1016/0034-5288(94)90091-4
]Search in Google Scholar
[
47. Balmer T V, Irvine D, Jones RS, Roberts MJ, Sungsby L, Taylor PM, Waterman AE, Waters C: Comparison of carprofen and pethidine as postoperative analgesics in the cat. J Small Anim Pract 1998, 39:158–64.10.1111/j.1748-5827.1998.tb03623.x9577756
]Search in Google Scholar
[
48. Martins TL, Kahvegian MAP, Noel-Morgan J, Leon-Román MA, Otsuki DA, Fantoni DT: Comparison of the effects of tramadol, codeine, and ketoprofen alone or in combination on postoperative pain and on concentrations of blood glucose, serum cortisol, and serum interleukin-6 in dogs undergoing maxillectomy or mandibulectomy. Am J Vet Res 2010, 71:1019–26.10.2460/ajvr.71.9.101920807140
]Search in Google Scholar
[
49. Grisneaux E, Pibarot P, Dupuis J, Blais D: Comparison of ketoprofen and carprofen administered prior to orthopedic surgery for control of postoperative pain in dogs. J Am Vet Med Assoc 1999, 215:1105–10.
]Search in Google Scholar
[
50. Evangelista MC, Silva RA, Cardozo LB, Kahvegian MAP, Rossetto TC, Matera JM, Fantoni DT: Comparison of preoperative tramadol and pethidine on postoperative pain in cats undergoing ovariohysterectomy. BMC Vet Res 2014, 10:1–8.10.1186/s12917-014-0252-1420019625310968
]Search in Google Scholar
[
51. Möllenhoff A, Nolte I, Kramer S: Anti-nociceptive efficacy of carprofen, levomethadone and buprenorphine for pain relief in cats following major orthopaedic surgery. J Vet Med Ser A 2005, 52:186–98.10.1111/j.1439-0442.2005.00710.x15882404
]Search in Google Scholar
[
52. Lu D-Z, Fan H-G, Jiang S, Tan L-J, Yu S-M, Zhang L-S, Ma K, Wang H-B: Anaesthesia and cardiopulmonary effects of tiletamine-zolazepam/xylazine/tramadol and its effects on nitric oxide, plasma endothelin, 6-keto-PGF 1α and thromboxanes B 2 in miniature pigs. Acta Vet Brno 2013, 82:103–7.10.2754/avb201382010103
]Search in Google Scholar
[
53. Srithunyarat T, Höglund O V, Hagman R, Olsson U, Stridsberg M, Lagerstedt A-S, Pettersson A: Catestatin, vasostatin, cortisol, temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale and visual analog scale for stress and pain behavior in dogs before and after ovariohysterectomy. BMC Res Notes 2016, 9:1–9.10.1186/s13104-016-2193-1496973327484122
]Search in Google Scholar
[
54. Robertson SA, Lascelles BDX, Taylor PM, Sear JW: PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration 1. J Vet Pharmacol Ther 2005, 28:453–60.10.1111/j.1365-2885.2005.00677.x16207308
]Search in Google Scholar
[
55. Lascelles BDX, Robertson SA: Use of thermal threshold response to evaluate the antinociceptive effects of butorphanol in cats. Am J Vet Res 2004, 65:1085–9.10.2460/ajvr.2004.65.108515334842
]Search in Google Scholar
[
56. Lopez DJ, Hayes GM, Fefer G, McCalla SA, LaLonde-Paul DF, Flanders JA, Sumner JP: Effect of subcutaneous closure technique on incisional complications and postoperative pain in cats undergoing midline celiotomy: A randomized, blinded, controlled trial. Vet Surg 2020, 49:321–8.10.1111/vsu.1334431664719
]Search in Google Scholar
[
57. Monteiro BP, Klinck MP, Moreau M, Guillot M, Steagall PVM, Edge DK, Pelletier J, Martel-Pelletier J, Gauvin D, Del Castillo JR: Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis. Vet Anaesth Analg 2016, 43:643–51.10.1111/vaa.1236026913836
]Search in Google Scholar
[
58. Slingsby LS, Watterman-Pearson AE: Comparison between meloxicam and carprofen for postoperative analgesia after feline ovariohysterectomy. J Small Anim Pract 2002, 43:286–9.10.1111/j.1748-5827.2002.tb00074.x12137147
]Search in Google Scholar
