Clinical Observations and Safety Profile of Oral Herbal Products, Souroubea and Platanus Spp; a Pilot-Toxicology Study in Dogs

1. Sherman BL, Mills DS: Canine anxieties and phobias: an update on separation anxiety and noise aversions. The Veterinary clinics of North America Small animal practice 2008, 38(5):1081-1106, vii.10.1016/j.cvsm.2008.04.012Search in Google Scholar

2. S hull-Selcer EA, Stagg W: Advances in the understanding and treatment of noise phobias. The Veterinary clinics of North America Small animal practice 1991, 21(2):353-367.10.1016/S0195-5616(91)50038-3Search in Google Scholar

3. D reschel NA: The effects of fear and anxiety on health and lifespan in pet dogs. Applied Animal Behaviour Science 2010, 125:157-162.10.1016/j.applanim.2010.04.003Search in Google Scholar

4. J oseph A. Araujoa b, Christina de Riveraa,b, Jennifer L. Ethierb, Gary M. Landsbergb,c,, Sagi Denenbergc SA, Norton W. Milgrama, : Anxitane tablets reduce fear of human beings in a model of anxiety-related behavior. Journal of Veterinary Behavior 2010, 5:268-275.10.1016/j.jveb.2010.02.003Search in Google Scholar

5. M ullally M, Kramp K, Cayer C, Saleem A, Ahmed F, McRae C, Baker J, Goulah A, Otorola M, Sanchez P et al: Anxiolytic activity of a supercritical carbon dioxide extract of Souroubea sympetala (Marcgraviaceae). Phytotherapy research : PTR 2011, 25(2):264-270.10.1002/ptr.3246Search in Google Scholar

6. C ayer C: In vivo behavioural characterization of anxiolytic botanicals: Souroubea sympetala. University of Ottawa, Ottawa: University of Ottawa, Ottawa; 2011.Search in Google Scholar

7. P isha E, Chai H, Lee IS, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CW, Fong HH, Kinghorn AD, Brown DM et al: Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nature medicine 1995, 1(10):1046-1051.10.1038/nm1095-1046Search in Google Scholar

8. S imone Fulda M, Klaus-Michael Debatin: Betulinic acid induces apoptosis through a direct effect on mitochondria in meuroectodermal tumors. Medical and Pediatric Oncology 2000, 35:616-618.10.1002/1096-911X(20001201)35:6<616::AID-MPO27>3.0.CO;2-NSearch in Google Scholar

9. F ujioka T, Kashiwada Y, Kilkuskie RE, Cosentino LM, Ballas LM, Jiang JB, Janzen WP, Chen IS, Lee KH: Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. Journal of natural products 1994, 57(2):243-247.10.1021/np50104a008Search in Google Scholar

10. Kashiwada Y, Hashimoto F, Cosentino LM, Chen CH, Garrett PE, Lee KH: Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents. Journal of medicinal chemistry 1996, 39(5):1016-1017.10.1021/jm950922qSearch in Google Scholar

11. Mukherjee PK, Saha K, Das J, Pal M, Saha BP: Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera. Planta medica 1997, 63(4):367-369.10.1055/s-2006-957705Search in Google Scholar

12. Chandramu C, Manohar RD, Krupadanam DG, Dashavantha RV: Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytotherapy research : PTR 2003, 17(2):129-134.10.1002/ptr.108812601674Search in Google Scholar

13. DP. L: Development and Validation of a Body Condition Score System for Dogs. Canine Practice 1997, 22:10-15.Search in Google Scholar

14. Smith RD, Ristic M, Huxsoll DL, Baylor RA: Platelet kinetics in canine ehrlichiosis: evidence for increased platelet destruction as the cause of thrombocytopenia. Infection and immunity 1975, 11(6):1216-1221.10.1128/iai.11.6.1216-1221.19754152021140846Search in Google Scholar

15. Romero LE, Meneses AI, Salazar L, Jimenez M, Romero JJ, Aguiar DM, Labruna MB, Dolz G: First isolation and molecular characterization of Ehrlichia canis in Costa Rica, Central America. Research in veterinary science 2011, 91(1):95-97. 10.1016/j.rvsc.2010.07.02120723954Search in Google Scholar