<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Oral solid dosage forms are most frequently administered with a glass of water which empties from the stomach relatively fast, but with a certain variability in its emptying kinetics. The purpose of this study was thus to simulate different individual water gastric emptying (GE) patterns in an <italic>in vitro</italic> glass-bead flow-through dissolution system. Further, the effect of GE on the dissolution of model drugs from immediate-release tablets was assessed by determining the amount of dissolved drug in the samples pumped out of the stomach compartment. Additionally, different HCl solutions were used as dissolution media to assess the effect of the variability of pH of the gastric fluid on the dissolution of three model drugs: paracetamol, diclofenac sodium, and dipyridamole. The difference in fast and slow GE kinetics resulted in different dissolution profiles of paracetamol in all studied media. For diclofenac sodium and dipyridamole tablets, the effect of GE kinetics was well observed only in media, where the solubility was not a limiting factor. Therefore, GE kinetics of co-ingested water influences the drug release from immediate-release tablets, however, in certain cases, other parameters influencing drug dissolution can partly or fully hinder the expression of this effect.</p>
</abstract>

Oral solid dosage forms are most frequently administered with a glass of water which empties from the stomach relatively fast, but with a certain variability in its emptying kinetics. The purpose of this study was thus to simulate different individual water gastric emptying (GE) patterns in an in vitro glass-bead flow-through dissolution system. Further, the effect of GE on the dissolution of model drugs from immediate-release tablets was assessed by determining the amount of dissolved drug in the samples pumped out of the stomach compartment. Additionally, different HCl solutions were used as dissolution media to assess the effect of the variability of pH of the gastric fluid on the dissolution of three model drugs: paracetamol, diclofenac sodium, and dipyridamole. The difference in fast and slow GE kinetics resulted in different dissolution profiles of paracetamol in all studied media. For diclofenac sodium and dipyridamole tablets, the effect of GE kinetics was well observed only in media, where the solubility was not a limiting factor. Therefore, GE kinetics of co-ingested water influences the drug release from immediate-release tablets, however, in certain cases, other parameters influencing drug dissolution can partly or fully hinder the expression of this effect.

Forecasting the effect of water gastric emptying patterns on model drug release in an <italic>in vitro</italic> glass-bead flow-through system

Faculty of Pharmacy Department of Biopharmaceutics and Pharmacokinetics

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Forecasting the effect of water gastric emptying patterns on model drug release in an  glass-bead flow-through system

Oral solid dosage forms are most frequently administered with a glass of water which empties from the stomach relatively fast, but with a certain variability...

Forecasting the effect of water gastric emptying patterns on model drug release in an in vitro glass-bead flow-through system

Pubblicato online: 30 mag 2024

Pagine: 269 - 287

Accettato: 13 feb 2024

DOI: https://doi.org/10.2478/acph-2024-0016

Parole chiave
water gastric emptying, gastric pH, glass-bead dissolution system, immediate-release tablets

© 2024 Tjaša Felicijan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Forecasting the effect of water gastric emptying patterns on model drug release in an in vitro glass-bead flow-through system

Pubblicato online: 30 mag 2024

Pagine: 269 - 287

Accettato: 13 feb 2024

DOI: https://doi.org/10.2478/acph-2024-0016

Parole chiavewater gastric emptying, gastric pH, glass-bead dissolution system, immediate-release tablets

© 2024 Tjaša Felicijan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
water gastric emptying, gastric pH, glass-bead dissolution system, immediate-release tablets