<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>In this study, the neuroprotective potential of arbutin (100 µmol L<sup>−1</sup>) pre-treatment and post-treatment against oxygen/ glucose deprivation (OGD) and reoxygenation (R) induced ischemic injury in cultured rat cortical neurons was explored. The OGD (60 min) and reoxygenation (24 h) treatment significantly (<italic>p</italic> &lt; 0.001) compromised the antioxidant defence in cultured neurons. Subsequently, an increase (<italic>p</italic> &lt; 0.001) in lipid peroxidation and inflammatory cytokines (tumour necrosis factor-α and nuclear factor kappa-B) declined neuron survival. In pre- and post-condition experiments, treatment with arbutin enhanced both survival (<italic>p</italic> &lt; 0.01) and integrity (<italic>p</italic> &lt; 0.05) of cultured neurons. Results showed that arbutin protects (<italic>p</italic> &lt; 0.05) against peroxidative changes, inflammation, and enhanced the antioxidant activity (<italic>e.g.,</italic> glutathione, superoxide dismutase and catalase) in cultured neurons subjected to OGD/R. It can be inferred that arbutin could protect against ischemic injuries and stroke. The anti-ischemic activity of arbutin can arrest post-stroke damage to the brain.</p>
</abstract>

In this study, the neuroprotective potential of arbutin (100 µmol L−1) pre-treatment and post-treatment against oxygen/ glucose deprivation (OGD) and reoxygenation (R) induced ischemic injury in cultured rat cortical neurons was explored. The OGD (60 min) and reoxygenation (24 h) treatment significantly (p < 0.001) compromised the antioxidant defence in cultured neurons. Subsequently, an increase (p < 0.001) in lipid peroxidation and inflammatory cytokines (tumour necrosis factor-α and nuclear factor kappa-B) declined neuron survival. In pre- and post-condition experiments, treatment with arbutin enhanced both survival (p < 0.01) and integrity (p < 0.05) of cultured neurons. Results showed that arbutin protects (p < 0.05) against peroxidative changes, inflammation, and enhanced the antioxidant activity (e.g., glutathione, superoxide dismutase and catalase) in cultured neurons subjected to OGD/R. It can be inferred that arbutin could protect against ischemic injuries and stroke. The anti-ischemic activity of arbutin can arrest post-stroke damage to the brain.

Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons

Department of Anesthesia and Perioperative Medicine

Shanghai Fourth People’s Hospital, Affiliated to Tongji University

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

In this study, the neuroprotective potential of arbutin (100 µmol L−1) pre-treatment and post-treatment against oxygen/ glucose deprivation (OGD) and...

Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons

Pubblicato online: 30 ago 2021

Pagine: 123 - 134

Accettato: 13 gen 2021

DOI: https://doi.org/10.2478/acph-2022-0002

Parole chiave
arbutin, cerebral ischemia, inflammation, oxidative stress

© 2022 Jingjing Tan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons

Pubblicato online: 30 ago 2021

Pagine: 123 - 134

Accettato: 13 gen 2021

DOI: https://doi.org/10.2478/acph-2022-0002

Parole chiavearbutin, cerebral ischemia, inflammation, oxidative stress

© 2022 Jingjing Tan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
arbutin, cerebral ischemia, inflammation, oxidative stress