[1. M. Duenas, B. Ojeda, A. Salazar, J. A. Mico and I. Failde, A review of chronic pain impact on patients, their social environment and the health care system, J. Pain Res.9 (2016) 457–467; https://doi.org/10.2147/jpr.s10589210.2147/JPR.S105892493502727418853]Search in Google Scholar
[2. B. B. Rahavard, K. D. Candido and N. N. Knezevic, Different pain responses to chronic and acute pain in various ethnic/racial groups, Pain Manag.7 (2017) 427–453; https://doi.org/10.2217/pmt-2017-005610.2217/pmt-2017-005628937312]Search in Google Scholar
[3. R. Cregg, G. Russo, A. Gubbay, R. Branford and H. Sato, Pharmacogenetics of analgesic drugs, Br. J. Pain7 (2013) 189–208; https://doi.org/10.1177/204946371350743910.1177/2049463713507439459016226516523]Search in Google Scholar
[4. A. D. Kaye, A. J. Garcia, O. M. Hall, M. G. Jeha, K. D. Cramer, A. L. Granier, A. Kallurkar, E. M. Cornett and R. D. Urman, Update on the pharmacogenomics of pain management, Pharmacogen. Pers. Med.12 (2019) 125–143; https://doi.org/10.2147/pgpm.s17915210.2147/PGPM.S179152661319231308726]Search in Google Scholar
[5. S. M. Gwaltney-Brant, Chapter 7 – Nutraceuticals in Hepatic Diseases, in Nutraceuticals: Efficacy, Safety and Toxicity (Ed. R. C. Gupta), Elsevier, Inc., Amsterdam 2016, pp. 87–99.10.1016/B978-0-12-802147-7.00007-3]Search in Google Scholar
[6. G. M. Nardi, E. F. Carvalho, S. K. Oliveira, V. K. Nardi, T. C. Gelinski, M. C. Bortoluzzi and M. Maraschin, Ilex paraguariensis promotes orofacial pain relief after formalin injection: involvement of noradrenergic pathway, Pharmacog. Res.8 (2016) 31–55; https://doi.org/10.4103/0974-8490.17864310.4103/0974-8490.178643482110427114689]Search in Google Scholar
[7. F. Pérez-Cano and M. Castell, Flavonoids, Inflammation and immune system, Nutrients8 (2016) 659–663; https://doi.org/10.3390/nu810065910.3390/nu8100659508404527775647]Search in Google Scholar
[8. L. M. D Souza, N. Dartora, C. T. Scoparo, T. R. Cipriani, P. A. J. Gorin, M. Iacomini and G. L. Sassaki, Comprehensive analysis of mate (Ilex paraguariensis) compounds: Development of chemical strategies for matesaponin analysis by mass spectrometry, J. Chromatogr. A1218 (2011) 7307–7315; https://doi.org/10.1016/j.chroma.2011.08.04710.1016/j.chroma.2011.08.04721899851]Search in Google Scholar
[9. N. Dartora, L. M. de Souza, A. P. Santana-Filho, M. Iacomini, A. T. Valduga, P. A. J Gorin and G. L. Sassaki, UPLC-PDA-MS evaluation of bioactive compounds from leaves of Ilex paraguariensis with different growth conditions, treatments and ageing, Food Chem. 129 (2011) 1453–1461; https://doi.org/10.1016/j.foodchem.2011.05.11210.1016/j.foodchem.2011.05.112]Search in Google Scholar
[10. P. G. Santiago, F. M. Gasparotto, K. S. Gebara, F. B. Bacha, F. A. dos Reis Lívero, M. A. Strapazon, E. L. Cardoso Junior, C. A. L. Kassuya, L. M. de Souza and A. Gasparotto Junior, Mechanisms underlying antiatherosclerotic properties of an enriched fraction obtained from Ilex paraguariensis A. St. – Hil., Phytomedicine34 (2017) 162–170; https://doi.org/10.1016/j.phymed.2017.08.01210.1016/j.phymed.2017.08.01228899499]Search in Google Scholar
[11. H. A. Twaij, A. Kery and N. K. Al-Khazraji, Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala, J. Ethnopharmacol. 9 (1983) 299–314; https://doi.org/10.1016/0378-8741(83)90037-510.1016/0378-8741(83)90037-5]Search in Google Scholar
[12. K. Manda and A. L. Bhatia, Role of β-carotene against acetaminophen-induced hepatotoxicity in mice, Nutr. Res. 23 (2003) 1097–1103; https://doi.org/10.1016/S0271-5317(03)00103-910.1016/S0271-5317(03)00103-9]Search in Google Scholar
[13. R. Koster, M. Anderson and E. J. De-Beer, Acetic acid for analgesic screening, Fed. Proc. 18 (1959) 412–418.]Search in Google Scholar
[14. H. C. Holland and E. A. Weldon, A note on a new technique of recording ambulation in the open field test and its validation, Acta Psychol. 28 (1968) 293–300; https://doi.org/10.1016/0001-6918(68)90020-610.1016/0001-6918(68)90020-6]Search in Google Scholar
[15. M. M. Campos, E. S. Fernandes, J. Ferreira, L. B. Bortolaza, A. R. Santos and J. B. Calixto, Pharmacological and neurochemical evidence for antidepressant-like effects of herbal product Catuama, Pharmacol. Biochem. Behav.78 (2004) 757–764; https://doi.org/10.1016/j.pbb.2004.05.02410.1016/j.pbb.2004.05.02415301932]Search in Google Scholar
[16. L. Bravo, L. Goya and E. Lecumberri, LC/MS characterization of phenolic constituents of mate (Ilex paraguariensis, St. Hil.) and its antioxidant activity compared to commonly beverages, Food Res. Int.40 (2007) 393–405; https://doi.org/10.1016/j.foodchem.2011.05.11210.1016/j.foodchem.2011.05.112]Search in Google Scholar
[17. M. Carini, R. M. Facino, G. Aldini, M. Calloni and L. Colombo, Characterization of phenolic antioxidants from mate (Ilex paraguariensis) by liquid chromatography mass spectrometry and liquid chromatography tandem mass spectrometry, Rapid Commun. Mass Spectrom. 12 (1998) 1813–1919; https://doi.org/10.1002/(SICI)1097-0231(19981130)12:22<1813::AID-RCM379>3.0.CO;2-%23]Search in Google Scholar
[18. L. M. Souza, T. R. Cipriani, C. F. Sant’Ana, M. Iacomini, P. A. J. Gorin and G. L. Sassaki, Heart-cutting two-dimensional (size exclusion x reversed phase) liquid chromatography–mass spectrometry analysis of flavonol glycosides from leaves of Maytenus ilicifolia, J. Chromatogr. A1216 (2009) 99–105; https://doi.org/10.1016/j.chroma.2008.11.03210.1016/j.chroma.2008.11.03219062030]Search in Google Scholar
[19. F. Andrade, C. A. C. Albuquerque, M. Maraschin and E. Silva, Safety assessment of yerba mate (Ilex paraguariensis) dried extract: Results of acute and 90 days subchronic toxicity studies in rats and rabbits, Food Chem. Toxicol. 50 (2012) 328–334; https://doi.org/10.1016/j.fct.2011.08.02]Search in Google Scholar
[20. W. R. Sousa, B. H. L. B. Lourenço, M. P. Reis, G. Donadel, M. A. A. Marques, E. L. Cardozo Junior, E. Jacomassi, S. T. Belettini, F. A. R. Lívero and A. Gasparotto Junior, Evaluation of reproductive toxicology of aqueous extract of yerba mate (Ilex paraguariensis A. St.-Hil.), a traditional South American beverage, J. Med. Food.22 (2019) 97–101; https://doi.org/10.1089/jmf.2018.006010.1089/jmf.2018.006030335566]Search in Google Scholar
[21. T. R. Pasquali, S. M. D. Macedo, S. S. Roman, V. Dal Prá, R. L. Cansian, A. J. Mossi, V. J. Oliveira and M. A. Mazzuti, Acute toxicity and anti-inflammatory effects of supercritical extracts of Ilex paraguariensis, Afr. J. Pharm. Pharmacol. 5 (2011) 1162–1169; https://doi.org/10.5897/AJPP11.234]Search in Google Scholar
[22. S. H. Jang, M. A. Hossain, J. S. Lee, Md. A. Reza, S. P. Lee, J. Kang and S-C. Park, Hepatoprotective effects of Ilex paraguariensis st. Hilaire (yerba mate) extract in rats, Indian J. Trad. Know.17 (2018) 707–715.]Search in Google Scholar
[23. M. R. McGill, The past and present of serum aminotransferases and the future of liver injury bio-markers, EXCLI J.15 (2016) 817–828; https://doi.org/10.17179/excli2016-800]Search in Google Scholar
[24. D. Burukoglu, C. Baycu, F. Taplamacioglu, E. Sahin and E. Bektur, Effects of nonsteroidal anti-inflammatory meloxicam on stomach, kidney, and liver of rats, Toxicol. Ind. Health32 (2014) 980–986; https://doi.org/10.1177/074823371453848410.1177/074823371453848424958741]Search in Google Scholar
[25. V. Noriega, H. F. Miranda, J. C. Prieto, R. Sotomayor-Zárate and F. Sierralta, Involvement of NO in antinociception of NSAIDS in murine formalin hind paw assay, Drug Res.70 (2020) 145–150; https://doi.org/10.1055/a-1095-541810.1055/a-1095-541832000276]Search in Google Scholar
[26. A. Barden, M. Phillips, E. Mas, L. M. Hill, I. Mowat, P. Loh, T. Corcoran and T. A. Mori, Effects of antiemetic doses of dexamethasone on plasma mediators of inflammation resolution and pain after surgery in women, Prostag. Other Lip. Med.149 (2020) Article ID 106427; https://doi.org/10.1016/j.pros-taglandins.2020.106427]Search in Google Scholar
[27. T. M. Z. Alhouzani, M. Saleem, S. Khadka, S. M. M. Al-Subari, D. B. Shrestha, M. Rizvi and I. A. Butt, Toxicity profiles of commonly used anti-inflammatory drugs in geriatrics, Europasian J. Med. Sci.2 (2020) 2 (issue 3, 10 pages); https://doi.org/10.46405/ejms.v2i2.10710.46405/ejms.v2i2.107]Search in Google Scholar
[28. R. H. Patil, M. N. Kumar, K.M. Kiran, R. Nagesh, K. Kavya, R. L. Babu, G. T. Ramesh and S. C. Sharma, Dexamethasone inhibits inflammatory response via down regulation of AP-1 transcription factor in human lung epithelial cells, Gene645 (2018) 85–94; https://doi.org/10.1016/j.gene.2017.12.02410.1016/j.gene.2017.12.024]Search in Google Scholar
[29. R. S. Barreto, J. S. Quintans, R. K. L. Amarante, T. S. Nascimento, R. S. Amarante, A. S. Barreto, E. W. M. Pereira, M. C. Duarte, H. D. M. Coutinho and I. R. A. Menezes, Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (–)-α-bisabolol, its main compound, in mice, J. Ethnopharmacol.191 (2016) 9–18; https://doi.org/10.1016/j.jep.2016.06.02210.1016/j.jep.2016.06.022]Search in Google Scholar
[30. S. Hunskaar and K. Hole, The formalin test in mice – dissociation between inflammatory and non inflammatory pain, Pain30 (1987) 103–114; https://doi.org/10.1016/0304-3959(87)90088-110.1016/0304-3959(87)90088-1]Search in Google Scholar
[31. S. M. A. Bahamonde, M. L. Flores, O. L. Cordoba, C. A. Taira and S. Gorzalczany, Antinociceptive and anti-inflammatory activities of an aqueous extract of Chiliotrichum diffusum, Rev. Bras. Farmacog. 23 (2013) 699–705; https://doi.org/10.1590/S0102-695X201300500005110.1590/S0102-695X2013005000051]Search in Google Scholar
[32. D. W. Lim, J. G. Kim, T. Han, S. K. Jung, E. Y. Lim, D. Han and Y. T. Kim, Analgesic Effect of Ilex paraguariensis extract on postoperative and neuropathic pain in rats, Biol. Pharm. Bull. 38 (2015) 1573–1579; https://doi.org/10.1248/bpb.b15-0036010.1248/bpb.b15-0036026228736]Search in Google Scholar
[33. G. E. Lombardo, S. Cirmi, L. Musumeci, S. Pergolizzi, A. Maugeri, C. Russo, C. Mannucci, G. Calapai and M. Navarra, Mechanisms underlying the anti-inflammatory activity of bergamot essential oil and its antinociceptive effects, Plants9 (2020) 704–720; https://doi.org/10.3390/plants906070410.3390/plants9060704735601532492797]Search in Google Scholar
[34. E. Tamaddonfard, S. Tamaddonfard and S. Cheraghiyan, Effects of intracerebroventricular injection of vitamin B12 on formalin-induced muscle pain in rats: role of cyclooxygenase pathway and opioid receptors, Vet. Res. Forum9 (2018) 329–335; https://doi.org/10.30466/vrf.2018.33104]Search in Google Scholar
[35. E. F. Carvalho, S. K. Oliveira, V. K. Nardi, T. C. Gelinski, M. C. Bortoluzzi, M. Maraschin and G. M. Nardi, Ilex paraguariensis promotes orofacial pain relief after formalin injection: involvement of noradrenergic pathway, Pharmacogn. Res. 8 (2016) 31–37; https://doi.org/10.4103/0974-8490.17864310.4103/0974-8490.178643482110427114689]Search in Google Scholar
[36. W. A. Kukula-Koch and J. Widelski, Chapter 9 – Alkaloids, in Pharmacognosy, Elsevier Inc., Amsterdam 2017, pp. 163–198.10.1016/B978-0-12-802104-0.00009-3]Search in Google Scholar
[37. E. H. Al-Khateeb, G. A. Al-Assi, A. K. Shakya, N. Al-Rawi and N. Shalan, Antioxidant potential of Pistacia Vera L. fruit hull, Anchusa Strigosa flowers and Ilex Paraguariensis A. St.-Hil. leaves extract, Orient. J. Chem.35 (2019) 982–986; https://doi.org/10.13005/ojc/35030910.13005/ojc/350309]Search in Google Scholar
[38. R. P. Barcelos, F. D. Lima, N. R. de Carvalho, G. Bresciani and L. F. Royes, Caffeine effects on systemic metabolism, oxidative-inflammatory pathways, and on exercise performance, Nutr. Res.80 (2020) 1–17; https://doi.org/10.1016/j.nutres.2020.05.00510.1016/j.nutres.2020.05.00532589582]Search in Google Scholar
[39. C. H. Blum-Silva, V. C. Chaves, E. P. Schenkel, G. C. Coelho and F. H. Reginatto, The influence of leaf age on methylxanthines, total phenolic content, and free radical scavenging capacity of Ilex paraguariensis aqueous extracts, Rev. Bras. Farmacog.25 (2015) 1–6; https://doi.org/10.1016/j.bjp.2015.01.00210.1016/j.bjp.2015.01.002]Search in Google Scholar
[40. C. F. Silva, P. Nardin, M. Grings, J. N. Uecker, J. H. Cerqueira, J. A. Rincón, R. T. Abib, A. Schneider, C. C. Barros, R. Andreazza and S. Pieniz, Evaluation of the redox state of Wistar Rats submitted to high-fat diet supplemented with infusion of Ilex paraguariensis, Braz. Arch. Biol. Technol.61 (2018) e18161189 (14 pages); https://doi.org/10.1590/1678-4324-201816118910.1590/1678-4324-2018161189]Search in Google Scholar