<abstract xmlns="http://www.w3.org/1999/xhtml">Little is known about the pharmacological activities of <italic>Iris adriatica</italic> (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using <italic>Mycobacterium smegmatis</italic> mc2 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L−1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone, responsible for the resistance-modulatory activity of this plant.</abstract>

Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc2 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L−1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone, responsible for the resistance-modulatory activity of this plant.

Phenolic compounds of <italic>Iris adriatica</italic> and their antimycobacterial effects

Institute of Pharmaceutical Sciences, Department of Pharmacognosy

Faculty of Science, Department of Biology (Botany)

Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry

Grigore T. Popa University of Medicine and Pharmacy Iasi

Department of Pharmacognosy with Medicinal Plant Unit

Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Botany

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Phenolic compounds of  and their antimycobacterial effects

Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a...

Phenolic compounds of Iris adriatica and their antimycobacterial effects

Pubblicato online: 21 ott 2019

Pagine: 673 - 681

Accettato: 17 mar 2019

DOI: https://doi.org/10.2478/acph-2019-0037

Parole chiave
Radix Iridis, phenolic compounds, resistance modulation, ethidium bromide, MIC

© 2019 Sandra Ochensberger et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Phenolic compounds of Iris adriatica and their antimycobacterial effects

Pubblicato online: 21 ott 2019

Pagine: 673 - 681

Accettato: 17 mar 2019

DOI: https://doi.org/10.2478/acph-2019-0037

Parole chiaveRadix Iridis, phenolic compounds, resistance modulation, ethidium bromide, MIC

© 2019 Sandra Ochensberger et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
Radix Iridis, phenolic compounds, resistance modulation, ethidium bromide, MIC