<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (<bold>4a-j</bold>). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.</p></abstract>

Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.

Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety

Department of Chemistry, Canara Engineering College, Benjanapadavu Mangalore-574219, Karnataka, India

PG Department of Medicinal Chemistry SDM College, Ujire-574240, Karnataka India

Acta Pharmaceutica

Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich...

Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety

Pubblicato online: 10 lug 2013

Pagine: 231 - 239

DOI: https://doi.org/10.2478/acph-2013-0016

Parole chiave
imidazole derivatives, Mannich bases, oxadiazole, antibacterial activity, antifungal activity

This content is open access.

Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety

Pubblicato online: 10 lug 2013

Pagine: 231 - 239

DOI: https://doi.org/10.2478/acph-2013-0016

Parole chiaveimidazole derivatives, Mannich bases, oxadiazole, antibacterial activity, antifungal activity

This content is open access.

Parole chiave
imidazole derivatives, Mannich bases, oxadiazole, antibacterial activity, antifungal activity