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The Monoclonal Gammopathies of Renal Significance

Kleinova Patricia

Kleinova Patricia

  • Transplant-Nephrology Department, University Hospital Martin
  • Clinic of Internal Medicine I., University Hospital Martin and Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaMartin, Slovakia
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Patricia, Kleinova
, 
Blichova Timea

Blichova Timea

  • Transplant-Nephrology Department, University Hospital Martin
  • Clinic of Internal Medicine I., University Hospital Martin and Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaMartin, Slovakia
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Timea, Blichova
, 
Beliancinova Monika

Beliancinova Monika

  • Transplant-Nephrology Department, University Hospital Martin
  • Clinic of Internal Medicine I., University Hospital Martin and Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaMartin, Slovakia
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Monika, Beliancinova
, 
Vnucak Matej

Vnucak Matej

  • Transplant-Nephrology Department, University Hospital Martin
  • Clinic of Internal Medicine I., University Hospital Martin and Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaMartin, Slovakia
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Matej, Vnucak
, 
Granak Karol

Granak Karol

  • Transplant-Nephrology Department, University Hospital Martin
  • Clinic of Internal Medicine I., University Hospital Martin and Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaMartin, Slovakia
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Karol, Granak
 e 
Dedinska Ivana

Dedinska Ivana

  • Transplant-Nephrology Department, University Hospital Martin
  • Clinic of Internal Medicine I., University Hospital Martin and Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaMartin, Slovakia
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Ivana, Dedinska
  
31 ago 2024
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Pubblicato online: 31 ago 2024
Pagine: 92 - 99
Ricevuto: 03 giu 2024
Accettato: 27 giu 2024
DOI: https://doi.org/10.2478/acm-2024-0012
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© 2024 Kleinova Patricia et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

Diagnostic algorithm for AKI (12)
Diagnostic algorithm for AKI (12)

Fig. 2

Diagnostic algorithm for CKD (12)
Diagnostic algorithm for CKD (12)

Diagnostic criteria for multiple myeloma (11)

Criteria Definition
Sixty % 60 % plasma cell infiltration in bone marrow
Light chain FLC κ/λ ratio > 100
MRI > 1 focal bone lesion
Calcium Hypercalcemia > 2.75 mmol/l or > 0.25 mmol/l above upper limit of normal
Renal insufficiency Creatinine > 173 μmol/l or creatinine clearence < 40ml/min
Anemia Hb < 100 g/l or > 20g/l below lower limit of normal
Bone lesions ≥ 1 osteolysis on skeletal radiography: X-ray, CT or PET/CT

Interpretation of the determination FLC (1,2)

Parameter FLC κappa FLC λambda κ/λ ratio
Normal ratio 3,3 – 19,4 mg/l 5,5 – 26,3 mg/l 0,26 – 1,65
Monoclonal gammopathy increased normal/decreased increased
Monoclonal gammopathy normal/decreased increased decreased
Bi/oligoclonal diseases increased increased varied*
Polyclonal diseases increased increased normal
Renal injury increased increased slightly increased
Reference values – nephrological patients**

0,46 – 2.62 (45 – 59)

0.48 – 3.38 (30 – 44)

0.54 – 3.30 (< 30)
Bone marrow suppression decreased decreased normal
Lingua:
Inglese
Frequenza di pubblicazione:
3 volte all'anno
Argomenti della rivista:
Medicina, Medicina clinica, Medicina interna, Cardiologia
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