<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Lung silicosis is a serious pulmonary disease caused by an exposure of lung to inhaled silicon dioxide (SiO<sub>2</sub>) or silica. Although pathomechanisms of the disease have not been fully elucidated, oxidative stress has been recognized as a fundamental factor triggering a fibrotizing inflammation leading to irreversible changes in lung tissue. Based on this knowledge, therapeutic potential of various antioxidants has been intensively discussed. Among them, N-acetylcysteine with its multiple anti-inflammatory and antioxidant actions and a long-term experience with its clinical use in various diseases appears as a very promising choice. The purpose of this article is to review the therapeutic effects of N-acetylcysteine particularly in relation to a lung injury and to point out a potential of N-acetylcysteine in the treatment of lung silicosis.</p>
</abstract>

Lung silicosis is a serious pulmonary disease caused by an exposure of lung to inhaled silicon dioxide (SiO2) or silica. Although pathomechanisms of the disease have not been fully elucidated, oxidative stress has been recognized as a fundamental factor triggering a fibrotizing inflammation leading to irreversible changes in lung tissue. Based on this knowledge, therapeutic potential of various antioxidants has been intensively discussed. Among them, N-acetylcysteine with its multiple anti-inflammatory and antioxidant actions and a long-term experience with its clinical use in various diseases appears as a very promising choice. The purpose of this article is to review the therapeutic effects of N-acetylcysteine particularly in relation to a lung injury and to point out a potential of N-acetylcysteine in the treatment of lung silicosis.

What is a Therapeutic Potential of N-Acetylcysteine in Lung Silicosis?

Department of Physiology, Jessenius Faculty of Medicine in Martin

Acta Medica Martiniana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"What is a Therapeutic Potential of N-Acetylcysteine in Lung Silicosis?"}

Lung silicosis is a serious pulmonary disease caused by an exposure of lung to inhaled silicon dioxide (SiO2) or silica. Although pathomechanisms of the...

What is a Therapeutic Potential of N-Acetylcysteine in Lung Silicosis?

Pubblicato online: 27 dic 2021

Pagine: 80 - 89

Ricevuto: 29 ott 2021

Accettato: 29 nov 2021

DOI: https://doi.org/10.2478/acm-2021-0011

Parole chiave
silica, lung silicosis, oxidative stress, N-acetylcysteine, antioxidants

© 2021 Adamcakova Jana et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

What is a Therapeutic Potential of N-Acetylcysteine in Lung Silicosis?

Pubblicato online: 27 dic 2021

Pagine: 80 - 89

Ricevuto: 29 ott 2021

Accettato: 29 nov 2021

DOI: https://doi.org/10.2478/acm-2021-0011

Parole chiavesilica, lung silicosis, oxidative stress, N-acetylcysteine, antioxidants

© 2021 Adamcakova Jana et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
silica, lung silicosis, oxidative stress, N-acetylcysteine, antioxidants