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Susceptibility of spike glycoprotein and RNA-dependent RNA polymerase of SARS-CoV-2 to mutation: in silico structural dynamics study

Toluwase Hezekiah Fatoki

Toluwase Hezekiah Fatoki

Department of Biochemistry, Federal University Oye-EkitiOye-Ekiti, Nigeria
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Fatoki, Toluwase Hezekiah
, 
Jude Akinyelu

Jude Akinyelu

Department of Biochemistry, Federal University Oye-EkitiOye-Ekiti, Nigeria
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Akinyelu, Jude
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Oluwafijimi Yomi Adetuyi

Oluwafijimi Yomi Adetuyi

Department of Biochemistry, Federal University Oye-EkitiOye-Ekiti, Nigeria
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Adetuyi, Oluwafijimi Yomi
, 
Temitope Olawale Jeje

Temitope Olawale Jeje

Department of Biochemistry, Federal University Oye-EkitiOye-Ekiti, Nigeria
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Jeje, Temitope Olawale
, 
Uchechukwu Nebo

Uchechukwu Nebo

Department of Microbiology, Federal University Oye-EkitiOye-Ekiti, Nigeria
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Nebo, Uchechukwu
, 
Jesupemi Mercy Fatoki

Jesupemi Mercy Fatoki

Department of Microbiology, Federal University of TechnologyAkure, Nigeria
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Fatoki, Jesupemi Mercy
 e 
Tolulope Mercy Kupolati

Tolulope Mercy Kupolati

Department of Zoology, Ekiti State UniversityAdo-Ekiti, Nigeria
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Kupolati, Tolulope Mercy
  
30 dic 2021
Susceptibility of spike glycoprotein and RNA-dependent RNA polymerase of SARS-CoV-2 to mutation: in silico structural dynamics study's Cover Image
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Pubblicato online: 30 dic 2021
Pagine: 148 - 152
Ricevuto: 02 ott 2021
Accettato: 18 nov 2021
DOI: https://doi.org/10.2478/acb-2021-0020
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© 2021 Toluwase Hezekiah Fatoki et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

FIGURE 1

Structural dynamics of RNA-dependent RNA polymerase (PDB ID: 7BW4, chain A) and its mutant consisting of G228C, P323L, V330E, and D824Y. (A) Superimposition of 10 model structures of 7BW4 from CAB-flex 2.0 server. (B) Superimposition of 10 model structures of 7BW4 mutant from CAB-flex 2.0 server. (C) RMSF of amino acids residues in 7BW4 and 7BW4 mutant. (D) Comparison of model protein structures from Dali Server
Structural dynamics of RNA-dependent RNA polymerase (PDB ID: 7BW4, chain A) and its mutant consisting of G228C, P323L, V330E, and D824Y. (A) Superimposition of 10 model structures of 7BW4 from CAB-flex 2.0 server. (B) Superimposition of 10 model structures of 7BW4 mutant from CAB-flex 2.0 server. (C) RMSF of amino acids residues in 7BW4 and 7BW4 mutant. (D) Comparison of model protein structures from Dali Server

FIGURE 2

Structural dynamics of Spike glycoprotein (PDB ID: 7CAB, chain A). and its mutant consisting of T478K, E484K, N501Y, D614G, and A701V. (A) Superimposition of 10 model structures of 7CAB from CAB-flex 2.0 server. (B) Superimposition of 10 model structures of 7CAB mutant from CAB-flex 2.0 server. (C) RMSF of amino acids residues in 7CAB and 7CAB mutant. (D) Comparison of model protein structures from Dali Server
Structural dynamics of Spike glycoprotein (PDB ID: 7CAB, chain A). and its mutant consisting of T478K, E484K, N501Y, D614G, and A701V. (A) Superimposition of 10 model structures of 7CAB from CAB-flex 2.0 server. (B) Superimposition of 10 model structures of 7CAB mutant from CAB-flex 2.0 server. (C) RMSF of amino acids residues in 7CAB and 7CAB mutant. (D) Comparison of model protein structures from Dali Server
Lingua:
Inglese
Frequenza di pubblicazione:
4 volte all'anno
Argomenti della rivista:
Scienze biologiche, Biologia molecolare, Buiochimica
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