Transporter |
|
SLCO1B1 |
A388G rs2306283 |
ATV |
Indian |
A: 43G: 57 |
177 DL |
Greater LDL reduction (AA) |
[14] |
SIM |
Thai |
AA: 7.7AG: 34.8GG: 57.5 |
391 DL |
NS |
[10] |
RSV |
Chinese |
AA: 6.3AG: 35.8GG: 57.9 |
291 DL |
NS |
[11] |
RSV, SIM |
Chinese Han |
AA: 4.8AG: 35.1GG: 60.1 |
247 CAD, HCVD |
NS |
[12] |
T521C rs4149056 |
SIM |
Thai |
TT: 78.5TC: 19.4CC: 2.1 |
391 DL |
NS |
[10] |
RSV |
Chinese |
TT: 75.4TC: 22.8CC: 1.8 |
291 DL |
NS |
[11] |
RSV, SIM |
Chinese Han |
TT: 74.7TC: 23.3CC: 2.0 |
247 CAD, HCVD |
NS |
[12] |
G> A rs4149081 |
RSV, SIM |
Chinese Han |
GG: 22.7GA: 53.4AA: 23.9 |
247 CAD, HCVD |
Greater LDL reduction (A allele) |
[12] |
C463A rs11045819 |
ATV |
Indian |
C: 97A: 3 |
177 DL |
NS |
[14] |
T89595C rs4363657 |
SIM |
Thai |
TT: 41.2TC: 43.2CC: 15.6 |
391 DL |
NS |
[10] |
SLC10A1 |
*2 rs2296651 |
RSV |
Chinese |
*1*1: 84.0*1*2: 14.9*2*2: 1.1 |
291 DL |
NS |
[11] |
ABCA1 |
R219K |
PRV |
Chinese |
RK: 46.6RR: 38.3KK: 15.1 |
365 CAD |
Greater HDL increment (KK) |
[26] |
ABCC2 |
−24 C>T rs717620 |
SIM |
Chinese Han |
GG: 60.7GA: 31.4AA: 7.9 |
318 DL |
Low response of HDL elevation (A allele) |
[17] |
ATV |
Chinese Han |
NA |
318 HCVD |
Significant different in percentage of LDL change |
[18]# |
ABCB1 |
G2677T rs2032582 |
ATV |
Indian |
G: 35T: 65 |
177 DL |
Greater LDL reduction (T allele) |
[14] |
C3435T rs1045642 |
ATV |
Indian |
C: 39T: 61 |
177 DL |
Greater LDL reduction (T allele) |
[14] |
rs2235013, rs2235033, rs1128503, rs10276036 |
ATV |
Chinese Han |
NA |
318 HCVD |
Significant different in percentage of LDL change |
[18]# |
ABCG2 |
C421A rs2231142 |
RSV |
Chinese |
CC: 46.8CA: 39.1AA: 14.1 |
291 DL |
Lower LDL reduction (CC) |
[11] |
RSV |
Chinese |
CC: 50CA: 35.7AA: 14.3 |
386 HCVD, FH, RA |
Greater LDL reduction (AA/CA) |
[20] |
RSV |
Chinese Han |
CC: 51.8CA: 35.4AA: 12.8 |
305 DL |
Greater LDL reduction (AA) |
[21] |
G34A rs2231137 |
RSV |
Chinese |
GG: 46.7GA: 43.2AA: 10.1 |
386 HCVD, FH, RA |
Greater LDL reduction (GG) |
[20] |
ABCG5 |
rs6720173 |
ATV |
Indian |
C: 75G: 25 |
177 DL |
NS |
[14] |
ABCG8 |
rs4148222 |
ATV |
Chinese Han |
CC: 44.9CT: 43TT: 12.1 |
107 DL |
Lower baseline HDL (CC) |
[22] |
D18H rs11887534 |
ATV |
Indian |
DD: 88.7DH, HH: 11.3 |
213 CAD; 220 H |
NS |
[25] |
C1199A |
ATV |
Chinese Han |
CC: 75.1CA, AA: 24.9 |
181 DL |
NS |
[23] |
rs11887534, rs4148217, rs4148214, rs17606027, rs4952689, rs4953028 |
ATV |
Chinese Han |
- |
107 DL |
NS |
[22] |
Haplotypes |
V |
Chinese |
GCGACTGCC: 34.0GCGATCGCC: 28.3GCGATTGCC: 8.9ATTATCGAC: 5.3 |
386 DL |
Greater LDL reduction (ATTATCGAC haplotype) |
[24] |
|
Cytochrome P450 and related enzymes |
|
CYP2C9 |
rs1934967 |
V |
Chinese |
CC: 66.2CT: 30.1TT: 3.7 |
386 DL |
NS |
[24] |
*1 |
RSV |
Chinese |
*1*1: 90.4*1*3, *3*3: 9.6 |
218 DL |
Greater TC and LDL reduction (*1*3/*3*3) |
[33] |
*3 rs1057910 |
RSV |
Chinese |
*1*1: 93.8*1*3: 5.8*3*3: 0.4 |
291 DL |
NS |
[11] |
CYP2C19 |
*2 (rs4244285; |
ATV |
Chinese Han |
NA |
192 IS |
NS |
[32] |
*3 (rs4986893) |
RSV |
Chinese |
*1*1: 37.2*1*2, *1*3: 54.4*2*2, *2*3: 8.4 |
291 DL |
NS |
[11] |
rs10786172 |
V |
Chinese |
AA: 65.9AG: 30.2GG: 3.9 |
386 DL |
NS |
[24] |
*1 |
RSV |
Chinese |
*1*1, *1*2, *1*3: 51*2*2, *2*3, *3*3: 49 |
49 H |
Greater TG reduction (poor metabolisers: *2*2/*2*3/*3*3) |
[34] |
CYP2D6 |
*10(C188T) |
SIM |
Chinese (Ningxia Hui) |
CC: 33CT: 39TT: 28 |
200 DL |
Greater TC and LDL reduction (CC) |
[35] |
*10 rs1065852 |
ATV |
Chinese Han |
GG: 16.7GA: 49.5AA: 33.8 |
192 IS |
Greater LDL reduction (G allele) |
[32] |
CYP3A4 |
rs2242480 |
ATV |
Chinese Han |
CC: 51.0CT: 44.3TT: 4.7 |
192 IS |
Greater LDL reduction (C allele) |
[32] |
*1G |
SIM |
Chinese |
*1*1: 53.4*1*1G: 39.9*1G*1G: 6.7 |
273 DL |
NS |
[30] |
SIM, ATV |
Chinese |
*1*1: 49.31–52.3*1*1G: 40.70–45.6*1G*1G: 5.07–7.1 |
423 DL |
Greater TC reduction (*1G*1G) with ATV; NS with SIM |
[31] |
*22rs35599367 |
SIM |
Chinese |
No variant allele |
273 DL |
NA |
[30] |
rs2740574 |
ATV |
Indian |
A: 97G: 3 |
177 DL |
Greater LDL reduction (AA) |
[14] |
rs4986910 |
ATV |
Indian |
T: 99C: 1 |
177 DL |
NS |
[14] |
CYP3A5 |
*3 6986G>Ars776746 |
SIM |
Chinese |
*1*1: 6.7*1*3: 39.8*3*3: 53.5 |
273 DL |
NS |
[30] |
ATV |
Chinese |
*1*1: 4.5*1*3: 43.5*3*3: 52.0 |
179 DL |
NS |
[36] |
ATV |
Indian |
A: 26G: 74 |
177 DL |
NS |
[14] |
rs4646450, rs3800959, rs776746 |
ATV |
Chinese Han |
- |
107 DL |
NS |
[22] |
CYP3AP1 |
*3-44G>Ars217718 |
SIM |
Chinese Han |
*3*3: 44.4*1*3: 46.0*1*1: 9.6 |
202 DL |
Greater LDL reduction (*3*3 women) |
[37] |
ATV |
Chinese Han |
*3*3: 54.8*1*3: 41.8*1*1: 3.4 |
177 DL |
Greater TC reduction (*3*3 women) |
[37] |
CYP4F2 |
rs2108622 |
ATV |
Chinese Han |
NA |
192 IS |
NS |
[32] |
PPARA |
A>G rs4823613 |
SIM |
Chinese |
AA: 57.4AG: 37.4GG: 5.2 |
273 DL |
NS |
[30] |
POR |
*28 |
ATV |
Chinese |
CC: 31.8CT: 53.1TT: 15.1 |
179 DL |
Lower mean LDL (TT) |
[36] |
|
Apolipoproteins |
|
APOA5 |
T-1131C rs662799 |
V |
Chinese |
TT: 46.7TC: 46.7CC: 6.6 |
195 DL, HCVD |
Greater LDL reduction (TT);Greater HDL and TG reduction (TT; only ATV & SIM) |
[44] |
RSV |
Chinese |
TT: 47.8TC: 41.3CC: 10.9 |
386 DL, FH |
NS |
[45] |
APOE |
E2/E3/E4 rs7412, rs429358 |
RSV |
Chinese |
E2E2, E2E3: 8.7E3E3: 69.0E4E4, E4E3: 22.3 |
386 DL, FH |
NS |
[45] |
SIM |
Thai |
E2E2, E2E4: 0E2E3: 14.22E3E3: 62.22E3E4: 20.44E4E4: 3.11 |
225 DL |
Greater TC and LDL reduction (APOE2, APOE3 carriers) |
[47] |
rs4420638 |
RSV |
Chinese |
AA: 77.2AG: 20.7GG: 2.1 |
386 HCVD, FH, RA |
Greater LDL reduction (AA/AG) |
[20] |
APOA1 |
G75A |
PRV |
Chinese |
GG: 45.8AA: 14.5GA: 39.7 |
97 DL |
Greater TC and LDL reduction (AA/GA) |
[48] |
|
3-hydroxy-3-methyl-glutaryl-coenzyme A reductase |
|
HMGCR |
rs3931914 |
V |
Chinese |
GG: 47.4GC: 42.5CC: 10.1 |
386 DL |
NS |
[24] |
rs12916 |
V |
Chinese |
CC: 30.1CT: 50.9TT: 19.0 |
386 DL |
Greater LDL reduction (CT/TT) |
[24] |
Haplotypes |
V |
Chinese |
GCGTTCA: 44.2CCGTCCA: 23.5GTGACTA: 19.1CCATCCA: 7.4 |
386 DL |
Higher LDL (CCGTCCA haplotype) |
[24] |
rs3846662 |
ATV |
Korean |
GG: 54.2AA: 45.8 |
24 H |
Higher LDL (GG) |
[50] |
|
LDL receptor and related genes |
|
LDLR |
rs1433099 |
RSV |
Chinese |
CC: 52.5CT: 40.0TT: 7.5 |
386 HCVD, FH, RA |
Greater LDL reduction (CC/CT) |
[20] |
PCSK9 |
I474Vrs562556 |
SIM |
Thai |
II: 96.4IV: 3.6VV: 0 |
225 DL |
Greater LDL reduction (IV) |
[47] |
R46L rs11591147;E670G rs505151 |
SIM |
Thai |
NA |
225 DL |
NA |
[47] |
SREBF1 |
rs9902941 |
V |
Chinese |
CC: 84.4CT: 15.1TT: 0.5 |
386 DL |
Greater LDL reduction (CT/TT) |
[24] |
|
Enzymes involved in cholesterol elimination and reverse cholesterol transport |
|
CYP7A1 |
A-204C rs3808607 |
ATV |
Indian |
A: 59C: 41 |
177 DL |
Greater LDL reduction (AA) |
[14] |
ATV |
Chinese Han |
GG: 34.6GT: 50.5TT: 15.0 |
107 DL |
NS |
[22] |
ATV |
Chinese Han |
AA: 30.4AC: 47.0CC: 22.6 |
181 DL |
Greater TG reduction (AA) |
[23] |
rs4738687 |
V |
Chinese |
TT: 42.4TC: 42.1CC: 15.5 |
386 DL |
NS |
[24] |
rs2162459 |
V |
Chinese |
GG: 31.8GA: 49.9AA: 18.3 |
386 DL |
NS |
[24] |
ATV |
Chinese Han |
GG: 23.4GA: 54.2AA: 22.4 |
107 DL |
NS |
[22] |
rs8192870 |
ATV |
Chinese Han |
TT: 51.4TG: 44.9GG: 3.7 |
107 DL |
Greater LDL reduction (TT) |
[22] |
rs1457042, rs6997473, rs11786580, rs8192879 |
ATV |
Chinese Han |
- |
107 DL |
NS |
[22] |
rs3824260 |
SIM |
Chinese Han |
GG: 37.5GA: 44.3AA: 18.2 |
420 DL |
Lower LDL reduction (AA)Higher HDL reduction (GG) |
[53] |
CETP |
TaqIB |
SIM |
Thai |
B1B1:4B1B2: 83.6B2B2: 12.4 |
225 DL |
Greater TC and LDL reduction (B1 carriers) |
[47] |
LPL |
C1421G |
RSV |
Chinese |
CC: 76.7CG: 22.2GG: 1.1 |
386 HCVD, FH, RA |
Greater LDL reduction (CG/GG) |
[20] |
LCAT |
rs255052 |
RSV |
Chinese |
GG: 82.9GA: 16.6AA: 0.5 |
386 HCVD, FH, RA |
Greater LDL reduction (GG) |
[20] |
|
Other genes |
|
MMP9 |
C1562T rs3918242 |
SIM |
Chinese |
CC: 71.3CT: 26.0TT: 2.7 |
264 CAD |
Greater LDL reduction (TT) |
[71] |
EL |
2037T/C rs3744843 |
RSV |
Chinese |
TT: 56.2CT: 38.8CC: 5.0 |
121 CAD |
NS |
[76] |
2237 G/A rs3744841 |
RSV |
Chinese |
GG: 38.0GA: 49.6AA: 12.4 |
121 CAD |
NS |
[76] |
FMO3 |
Val257Met |
RSV |
Chinese |
GG: 59.5GA: 34.5AA: 6.0 |
386 HCVD, FH, RA |
Greater LDL reduction (GG) |
[20] |
PON1 |
Q192R |
SIM |
Chinese |
QQ: 23.7QR: 53.4RR: 22.9 |
236 CAD |
Greater HDL increment (RR) |
[64] |
TIMD4-HAVCR1 |
rs1501908 |
ATV |
Chinese Han |
CC: 51.0CG: 40.1GG: 8.9 |
724 H, CAD, IS |
Lower TC and LDL level (G allele) |
[69] |
rs12522248 |
ATV |
Chinese Han |
TT: 70.4TC: 26.2CC: 3.4 |
724 H, CAD, IS |
Lower TC and LDL level (C allele) |
[69] |
rs2036402 |
ATV |
Chinese Han |
TT: 79.3TC: 19.5CC: 1.2 |
724 H, CAD, IS |
Lower TC and LDL level (TC) |
[69] |
LEP |
G2548A |
SIM |
Chinese |
AA: 40.1GA: 54.2GG: 5.7 |
212 DL |
NS |
[61] |
LEPR |
Q223R |
SIM |
Chinese |
RR: 78.3QR: 21.7QQ: 0% |
212 DL |
Greater TC and TC reduction (RR) |
[61] |
A223G |
SIM |
Chinese |
GG: 74.0AG: 23.4AA: 2.6 |
312 CAD |
Lower HDL increment (AA) |
[62] |
FXR |
G-1Trs56163822 |
RSV |
Chinese |
GG: 81.6GT: 17.7TT: 0.7 |
385 DL |
Greater TC and LDL reduction (T allele) |
[66] |
SCAP |
A2386G |
RSV |
Indian |
AA: 36.6AG: 31.7GG:31.7 |
63 DL |
Greater TC and LDL reduction (G allele) |
[67] |
TNF-α |
C-857T |
U |
Japanese |
CC: 71.7CT, TT: 28.3 |
322 T2DM |
Higher LDL and resistant to statin (T allele) |
[70] |
NCAN/CILP2/PBX4 |
rs16996148 |
RSV |
Chinese |
GG: 81.5GT: 18.5 |
386 HCVD, FH, RA |
Greater LDL reduction (GG) |
[20] |