This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Noor S, Zubair M, Ahmad J. Diabetic foot ulcer—a review on pathophysiology, classification and microbial etiology. Diabetes Metab Syndr. 2015; 9:192–9.NoorSZubairMAhmadJDiabetic foot ulcer—a review on pathophysiology, classification and microbial etiology20159192910.1016/j.dsx.2015.04.00725982677Search in Google Scholar
Arshad M, Arshad S, Arshad S, Abbas H. The quality of life in patients with diabetic foot ulcers. J Diab Metab. 2020; 11:e101. doi: 10.35248/2155-6156.20.11.e101.ArshadMArshadSArshadSAbbasHThe quality of life in patients with diabetic foot ulcers202011e10110.35248/2155-6156.20.11.e101Open DOISearch in Google Scholar
Haghdoost A, Rezazadeh Kermani M, Sadghirad B, Baradaran H. Prevalence of type 2 diabetes in the Islamic Republic of Iran: systematic review and meta-analysis. Eastern Mediterr Health J. 2009: 15:591–9.HaghdoostARezazadeh KermaniMSadghiradBBaradaranHPrevalence of type 2 diabetes in the Islamic Republic of Iran: systematic review and meta-analysis200915591910.26719/2009.15.3.591Search in Google Scholar
Shafiee S, Raz A, Adibi N, Mansouri M, Annabestani Z, Mirzaeezadeh Z, et al. Assessment of the relationship between -1562C>T allele of MMP9 gene promoter with diabetic foot ulcer in type 2 diabetic patients referred to the clinic of diabetes & metabolic diseases. Iranian J Diabetes Metabol. 2018; 17:49–56. [in Persian; English title and abstract]ShafieeSRazAAdibiNMansouriMAnnabestaniZMirzaeezadehZAssessment of the relationship between -1562C>T allele of MMP9 gene promoter with diabetic foot ulcer in type 2 diabetic patients referred to the clinic of diabetes & metabolic diseases2018174956[in Persian; English title and abstract]Search in Google Scholar
Weledji EP, Fokam P. Treatment of the diabetic foot – to amputate or not? BMC Surg. 2014; 14:83. doi: 10.1186/1471-2482-14-83WeledjiEPFokamPTreatment of the diabetic foot – to amputate or not?2014148310.1186/1471-2482-14-83421899325344293Open DOISearch in Google Scholar
Cao Y, Gang X, Sun C, Wang G. Mesenchymal stem cells improve healing of diabetic foot ulcer. J Diabetes Res. 2017; 2017:9328347. doi: 10.1155/2017/9328347CaoYGangXSunCWangGMesenchymal stem cells improve healing of diabetic foot ulcer201720179328347.10.1155/2017/9328347536620128386568Open DOISearch in Google Scholar
Guo J, Dardik A, Fang K, Huang R, Gu Y. Meta-analysis on the treatment of diabetic foot ulcers with autologous stem cells. Stem Cell Res Ther. 2017; 8:228. doi: 10.1186/s13287-017-0683-2GuoJDardikAFangKHuangRGuYMeta-analysis on the treatment of diabetic foot ulcers with autologous stem cells2017822810.1186/s13287-017-0683-2564417129037219Open DOISearch in Google Scholar
Shu X, Shu S, Tang S, Yang L, Liu D, Li K, et al. Efficiency of stem cell based therapy in the treatment of diabetic foot ulcer: a meta-analysis. Endocr J. 2018; 65:403–13.ShuXShuSTangSYangLLiuDLiKEfficiency of stem cell based therapy in the treatment of diabetic foot ulcer: a meta-analysis2018654031310.1507/endocrj.EJ17-042429353870Search in Google Scholar
Heublein H, Bader A, Giri S. Preclinical and clinical evidence for stem cell therapies as treatment for diabetic wounds. Drug Discov Today. 2015; 20:703–17.HeubleinHBaderAGiriSPreclinical and clinical evidence for stem cell therapies as treatment for diabetic wounds2015207031710.1016/j.drudis.2015.01.00525603421Search in Google Scholar
Meamar R, Nasr-Esfahani MH, Mousavi SA, Basiri K. Stem cell therapy in amyotrophic lateral sclerosis. J Clin Neurosci. 2013; 20:1659–63.MeamarRNasr-EsfahaniMHMousaviSABasiriKStem cell therapy in amyotrophic lateral sclerosis20132016596310.1016/j.jocn.2013.04.02424148693Search in Google Scholar
Blumberg SN, Berger A, Hwang L, Pastar I, Warren SM, Chen W. The role of stem cells in the treatment of diabetic foot ulcers. Diabetes Res Clin Pract. 2012; 96:1–9.BlumbergSNBergerAHwangLPastarIWarrenSMChenWThe role of stem cells in the treatment of diabetic foot ulcers2012961910.1016/j.diabres.2011.10.03222142631Search in Google Scholar
Ariyanti AD, Zhang J, Marcelina O, Nugrahaningrum DA, Wang G, Kasim V, Wu S. Salidroside-pretreated mesenchymal stem cells enhance diabetic wound healing by promoting paracrine function and survival of mesenchymal stem cells under hyperglycemia. Stem Cells Transl Med. 2019; 8:404–14.AriyantiADZhangJMarcelinaONugrahaningrumDAWangGKasimVWuSSalidroside-pretreated mesenchymal stem cells enhance diabetic wound healing by promoting paracrine function and survival of mesenchymal stem cells under hyperglycemia201984041410.1002/sctm.18-0143643160730624028Search in Google Scholar
Holm JS, Toyserkani NM, Sorensen JA. Adipose-derived stem cells for treatment of chronic ulcers: current status. Stem Cell Res Ther. 2018; 9:142. doi: 10.1186/s13287-018-0887-0HolmJSToyserkaniNMSorensenJAAdipose-derived stem cells for treatment of chronic ulcers: current status2018914210.1186/s13287-018-0887-0595237029764508Open DOISearch in Google Scholar
Qin HL, Zhu XH, Zhang B, Zhou L, Wang WY. Clinical evaluation of human umbilical cord mesenchymal stem cell transplantation after angioplasty for diabetic foot. Exp Clin Endocrinol Diabetes. 2016; 124:497–503.QinHLZhuXHZhangBZhouLWangWYClinical evaluation of human umbilical cord mesenchymal stem cell transplantation after angioplasty for diabetic foot201612449750310.1055/s-0042-10368427219884Search in Google Scholar
Davey GC, Patil SB, O’Loughlin A, O’Brien T. Mesenchymal stem cell-based treatment for microvascular and secondary complications of diabetes mellitus. Front Endocrinol (Lausanne). 2014; 5:86. doi: 10.3389/fendo.2014.00086DaveyGCPatilSBO’LoughlinAO’BrienTMesenchymal stem cell-based treatment for microvascular and secondary complications of diabetes mellitus201458610.3389/fendo.2014.00086404767924936198Open DOISearch in Google Scholar
Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR. A stem cell molecular signature. Science. 2002; 298(5593):601–4.IvanovaNBDimosJTSchanielCHackneyJAMooreKALemischkaIRA stem cell molecular signature20022985593601410.1126/science.107382312228721Search in Google Scholar
Arwert EN, Hoste E, Watt FM. Epithelial stem cells, wound healing and cancer. Nature Rev Cancer. 2012; 12:170–80.ArwertENHosteEWattFMEpithelial stem cells, wound healing and cancer2012121708010.1038/nrc321722362215Search in Google Scholar
Li Z, Hu X, Zhong JF. Mesenchymal stem cells: characteristics, function, and application. Stem Cells Int. 2019; 2019:8106818. doi: 10.1155/2019/8106818LiZHuXZhongJFMesenchymal stem cells: characteristics, function, and application20192019810681810.1155/2019/8106818643137230956675Open DOISearch in Google Scholar
Banijamali RS, Soleimanjahi H, Soudi S, Karimi H, Abdoli A, Khorrami SMS, Zandi K. Kinetics of oncolytic reovirus T3D replication and growth pattern in mesenchymal stem cells. Cell J. 2020; 22:283–92.BanijamaliRSSoleimanjahiHSoudiSKarimiHAbdoliAKhorramiSMSZandiKKinetics of oncolytic reovirus T3D replication and growth pattern in mesenchymal stem cells20202228392Search in Google Scholar
Dash NR, Dash SN, Routray P, Mohapatra S, Mohapatra PC. Targeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells. Rejuvenation Res. 2009; 12:359–66.DashNRDashSNRoutrayPMohapatraSMohapatraPCTargeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells2009123596610.1089/rej.2009.087219929258Search in Google Scholar
Patel AN, Bartlett CE, Ichim TE. Mesenchymal Stem Cells. In: Perin EC, Miller LW, Taylor D, Willerson JT, editors. Stem cell and gene therapy for cardiovascular disease. Amsterdam: Elsevier Academic Press; 2016, p. 139–50.PatelANBartlettCEIchimTEMesenchymal Stem CellsIn:PerinECMillerLWTaylorDWillersonJTeditors.AmsterdamElsevier Academic Press20161395010.1016/B978-0-12-801888-0.00011-4Search in Google Scholar
Kong P, Xie X, Li F, Liu Y, Lu Y. Placenta mesenchymal stem cell accelerates wound healing by enhancing angiogenesis in diabetic Goto-Kakizaki (GK) rats. Biochem Biophys Res Commun. 2013; 438:410–9.KongPXieXLiFLiuYLuYPlacenta mesenchymal stem cell accelerates wound healing by enhancing angiogenesis in diabetic Goto-Kakizaki (GK) rats2013438410910.1016/j.bbrc.2013.07.08823899518Search in Google Scholar
Wang Y, Dan Q, Wang Q, Zhou N, Jin X, Hou Z, et al. [Human umbilic mesenchymal stromal cells repairs diabetic foot in rats associated with VEGF expressional change]. Sichuan Da Xue Xue Bao Yi Xue Ban [J Sichuan Univ. Med Sci Edition]. 2014; 45:29–33. [article in Chinese, English Abstract]WangYDanQWangQZhouNJinXHouZ[Human umbilic mesenchymal stromal cells repairs diabetic foot in rats associated with VEGF expressional change]2014452933[article in Chinese, English Abstract]Search in Google Scholar
Son W-S, Park HJ, Lee C-J, Kim S-N, Song SU, Park G, Lee Y-W. Supercritical drying of vascular endothelial growth factor in mesenchymal stem cells culture fluids. J Supercritical Fluids. 2020; 157:104710. doi: 10.1016/j.supflu.2019.104710SonW-SParkHJLeeC-JKimS-NSongSUParkGLeeY-WSupercritical drying of vascular endothelial growth factor in mesenchymal stem cells culture fluids2020157104710.10.1016/j.supflu.2019.104710Open DOISearch in Google Scholar
Shen L, Zeng W, Wu Y-X, Hou C-L, Chen W, Yang M-C, et al. Neurotrophin-3 accelerates wound healing in diabetic mice by promoting a paracrine response in mesenchymal stem cells. Cell Transplant. 2013; 22:1011–21.ShenLZengWWuY-XHouC-LChenWYangM-CNeurotrophin-3 accelerates wound healing in diabetic mice by promoting a paracrine response in mesenchymal stem cells20132210112110.3727/096368912X657495Search in Google Scholar
Tsyb A, Petrov V, Konoplyannikov A, Saypina E, Lepechina L, Kalsina SS, et al. In vitro inhibitory effect of mesenchymal stem cells on zymosan-induced production of reactive oxygen species. Bull Exp Biol Med. 2008; 146:158–64.TsybAPetrovVKonoplyannikovASaypinaELepechinaLKalsinaSSIn vitro inhibitory effect of mesenchymal stem cells on zymosan-induced production of reactive oxygen species20081461586410.1007/s10517-008-0238-8Search in Google Scholar
Pan G, Mu Y, Hou L, Liu J. Examining the therapeutic potential of various stem cell sources for differentiation into insulin-producing cells to treat diabetes. Ann Endocrinol (Paris). 2019; 80:47–53.PanGMuYHouLLiuJExamining the therapeutic potential of various stem cell sources for differentiation into insulin-producing cells to treat diabetes201980475310.1016/j.ando.2018.06.1084Search in Google Scholar
Wan J, Xia L, Liang W, Liu Y, Cai Q. Transplantation of bone marrow-derived mesenchymal stem cells promotes delayed wound healing in diabetic rats. J Diabetes Res. 2013; 2013:647107. doi: 10.1155/2013/647107WanJXiaLLiangWLiuYCaiQTransplantation of bone marrow-derived mesenchymal stem cells promotes delayed wound healing in diabetic rats20132013647107.10.1155/2013/647107Open DOISearch in Google Scholar
Wang L, Wang F, Zhao L, Yang W, Wan X, Yue C, Mo Z. Mesenchymal stem cells coated by the extracellular matrix promote wound healing in diabetic rats. Stem Cells Int. 2019; 2019:9564869. doi: 10.1155/2019/9564869. [Erratum: doi: 10.1155/2019/9581478]WangLWangFZhaoLYangWWanXYueCMoZMesenchymal stem cells coated by the extracellular matrix promote wound healing in diabetic rats201920199564869.10.1155/2019/9564869[Erratum: doi: 10.1155/2019/9581478]Open DOISearch in Google Scholar
Debin L, Youzhao J, Ziwen L, Xiaoyan L, Zhonghui Z, Bing C. Autologous transplantation of bone marrow mesenchymal stem cells on diabetic patients with lower limb ischemia. J Med Colleges PLA. 2008; 23:106–15.DebinLYouzhaoJZiwenLXiaoyanLZhonghuiZBingCAutologous transplantation of bone marrow mesenchymal stem cells on diabetic patients with lower limb ischemia2008231061510.1016/S1000-1948(08)60031-3Search in Google Scholar
Jain P, Perakath B, Ranjan Jesudason M, Nayak S. The effect of autologous bone marrow-derived cells on healing chronic lower extremity wounds: results of a randomized controlled study. Ostomy Wound Manage. 2011; 57:38–34.JainPPerakathBRanjan JesudasonMNayakSThe effect of autologous bone marrow-derived cells on healing chronic lower extremity wounds: results of a randomized controlled study2011573834Search in Google Scholar
Liu Z, Yu D, Xu J, Li X, Wang X, He Z, Zhao T. Human umbilical cord mesenchymal stem cells improve irradiation-induced skin ulcers healing of rat models. Biomed Pharmacother. 2018; 101:729–36.LiuZYuDXuJLiXWangXHeZZhaoTHuman umbilical cord mesenchymal stem cells improve irradiation-induced skin ulcers healing of rat models20181017293610.1016/j.biopha.2018.02.09329524881Search in Google Scholar
Kirana S, Stratmann B, Prante C, Prohaska W, Koerperich H, Lammers D, et al. Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients. Int J Clin Pract. 2012; 66:384–93.KiranaSStratmannBPranteCProhaskaWKoerperichHLammersDAutologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients2012663849310.1111/j.1742-1241.2011.02886.x22284892Search in Google Scholar
Lu D, Chen B, Liang Z, Deng W, Jiang Y, Li S, et al. Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial. Diabetes Res Clin Pract. 2011; 92:26–36.LuDChenBLiangZDengWJiangYLiSComparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial201192263610.1016/j.diabres.2010.12.01021216483Search in Google Scholar
Vojtaššák J, Danišovič L, Kubeš M, Bakoš D, Jarabek L, Uličná M, Blaško M. Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot. Neuroendocrinol Lett. 2006; 27(Suppl 2):134–7.VojtaššákJDanišovičLKubešMBakošDJarabekLUličnáMBlaškoMAutologous biograft and mesenchymal stem cells in treatment of the diabetic foot200627Suppl 21347Search in Google Scholar
Wu Q, Lei X, Chen L, Zheng Y, Huang H, Qian C, Liang Z. Autologous platelet-rich gel combined with in vitro amplification of bone marrow mesenchymal stem cell transplantation to treat the diabetic foot ulcer: a case report. Ann Transl Med. 2018; 6:307. doi: 10.21037/atm.2018.07.12WuQLeiXChenLZhengYHuangHQianCLiangZAutologous platelet-rich gel combined with in vitro amplification of bone marrow mesenchymal stem cell transplantation to treat the diabetic foot ulcer: a case report2018630710.21037/atm.2018.07.12612320630211195Open DOISearch in Google Scholar
Li X-Y, Zheng Z-H, Li X-Y, Guo J, Zhang Y, Li H, et al. Treatment of foot disease in patients with type 2 diabetes mellitus using human umbilical cord blood mesenchymal stem cells: response and correction of immunological anomalies. Curr Pharm Des. 2013; 19:4893–9.LiX-YZhengZ-HLiX-YGuoJZhangYLiHTreatment of foot disease in patients with type 2 diabetes mellitus using human umbilical cord blood mesenchymal stem cells: response and correction of immunological anomalies2013194893910.2174/1381612811319999032623343120Search in Google Scholar
Qin H-L, He K-W, Bin G, Ji Y-L, Huang Y-C, Wang S-Q, et al. Human umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation. Zhongguo Zuzhi Gongcheng Yanjiu [Chinese J Tissue Eng Res]. 2013; 17:2544–51.QinH-LHeK-WBinGJiY-LHuangY-CWangS-QHuman umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation201317254451Search in Google Scholar
Han S-K, Kim H-R, Kim W-K. The treatment of diabetic foot ulcers with uncultured, processed lipoaspirate cells: a pilot study. Wound Repair Regen. 2010; 18:342–8.HanS-KKimH-RKimW-KThe treatment of diabetic foot ulcers with uncultured, processed lipoaspirate cells: a pilot study201018342810.1111/j.1524-475X.2010.00593.x20492632Search in Google Scholar
Lee HC, An SG, Lee HW, Park J-S, Cha KS, Hong TJ, et al. Safety and effect of adipose tissue-derived stem cell implantation in patients with critical limb ischemia: a pilot study. Circ J. 2012; 76:1750–60.LeeHCAnSGLeeHWParkJ-SChaKSHongTJSafety and effect of adipose tissue-derived stem cell implantation in patients with critical limb ischemia: a pilot study20127617506010.1253/circj.CJ-11-113522498564Search in Google Scholar
Masłowski L, Paprocka M, Czyżewska-Buczyńska A, Bielawska-Pohl A, Duś D, Grendziak R, et al. Autotransplantation of the adipose tissue-derived mesenchymal stem cells in therapy of venous stasis ulcers. Arch Immunol Ther Exp (Warsz). 2020; 68:5. doi: 10.1007/s00005-020-00571-9MasłowskiLPaprockaMCzyżewska-BuczyńskaABielawska-PohlADuśDGrendziakRAutotransplantation of the adipose tissue-derived mesenchymal stem cells in therapy of venous stasis ulcers202068510.1007/s00005-020-00571-932060631Open DOISearch in Google Scholar
Marino G, Moraci M, Armenia E, Orabona C, Sergio R, De Sena G, et al. Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease. J Surg Res. 2013; 185:36–44.MarinoGMoraciMArmeniaEOrabonaCSergioRDe SenaGTherapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease2013185364410.1016/j.jss.2013.05.02423773718Search in Google Scholar
Moon K-C, Suh H-S, Kim K-B, Han S-K, Young K-W, Lee J-W, Kim M-H. Potential of allogeneic adipose-derived stem cell–hydrogel complex for treating diabetic foot ulcers. Diabetes. 2019; 68:837–46.MoonK-CSuhH-SKimK-BHanS-KYoungK-WLeeJ-WKimM-HPotential of allogeneic adipose-derived stem cell–hydrogel complex for treating diabetic foot ulcers2019688374610.2337/db18-069930679183Search in Google Scholar
Viswanathan C, Shetty P, Sarang S, Cooper K, Ghosh D, Bal A. Role of combination cell therapy in non-healing diabetic ulcers in patients with severe peripheral arterial disease – a preliminary report on five cases. J Diabetic Foot Complications. 2013; 5:1–14.ViswanathanCShettyPSarangSCooperKGhoshDBalARole of combination cell therapy in non-healing diabetic ulcers in patients with severe peripheral arterial disease – a preliminary report on five cases20135114Search in Google Scholar
Tanaka R, Masuda H, Kato S, Imagawa K, Kanabuchi K, Nakashioya C, et al. Autologous G-CSF-mobilized peripheral blood CD34+ cell therapy for diabetic patients with chronic nonhealing ulcer. Cell Transplant. 2014; 23:167–79.TanakaRMasudaHKatoSImagawaKKanabuchiKNakashioyaCAutologous G-CSF-mobilized peripheral blood CD34+ cell therapy for diabetic patients with chronic nonhealing ulcer2014231677910.3727/096368912X65800723107450Search in Google Scholar
Xu SM, Liang T. Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene. Exp Ther Med. 2016; 11:283–8.XuSMLiangTClinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene201611283810.3892/etm.2015.2888472710026889255Search in Google Scholar
Stiner R, Alexander M, Liu G, Liao W, Liu Y, Yu J, et al. Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes. Cell Tissue Res. 2019; 378:155–62.StinerRAlexanderMLiuGLiaoWLiuYYuJTransplantation of stem cells from umbilical cord blood as therapy for type I diabetes20193781556210.1007/s00441-019-03046-231209568Search in Google Scholar
Lopes L, Setia O, Aurshina A, Liu S, Hu H, Isaji T, et al. Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research. Stem Cell Res Ther. 2018; 9:188. doi: 10.1186/s13287-018-0938-6LopesLSetiaOAurshinaALiuSHuHIsajiTStem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research2018918810.1186/s13287-018-0938-6604225429996912Open DOISearch in Google Scholar
Abdal Dayem A, Lee SB, Kim K, Lim KM, Jeon T-I, Seok J, Cho S-G. Production of mesenchymal stem cells through stem cell reprogramming. Int J Mol Sci. 2019; 20:1922. doi: 10.3390/ijms20081922Abdal DayemALeeSBKimKLimKMJeonT-ISeokJChoS-GProduction of mesenchymal stem cells through stem cell reprogramming201920192210.3390/ijms20081922651465431003536Open DOISearch in Google Scholar
Lau T, Lam F, Lau K, Chan Y, Lee K, Sahota D, et al. Pharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer. J Ethnopharmacol. 2009; 123:155–62.LauTLamFLauKChanYLeeKSahotaDPharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer20091231556210.1016/j.jep.2009.02.01019429355Search in Google Scholar
Watt SM, Gullo F, van der Garde M, Markeson D, Camicia R, Khoo CP, Zwaginga JJ. The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential. Br Med Bull. 2013; 108:25–53.WattSMGulloFvan der GardeMMarkesonDCamiciaRKhooCPZwagingaJJThe angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential2013108255310.1093/bmb/ldt031384287524152971Search in Google Scholar
Zhao Q-S, Xia N, Zhao N, Li M, Bi C-L, Zhu Q, et al. Localization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats. Int J Biol Sci. 2014; 10:80–9.ZhaoQ-SXiaNZhaoNLiMBiC-LZhuQLocalization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats20141080910.7150/ijbs.7237387959424391454Search in Google Scholar
Zhou N, Wang Q-P, Jin X-F, Hou Z-L, Peng B-K, Dan Q-Q, Wang T-H. [Effect of human umbilici mesenchymal stromal cells implantation on the BDNF expression in diabetic foot rats]. Sichuan Da Xue Xue Bao Yi Xue Ban [J Sichuan Univ. Med Sci Edition]. 2013; 44:931–4. [article in Chinese, English Abstract]ZhouNWangQ-PJinX-FHouZ-LPengB-KDanQ-QWangT-H[Effect of human umbilici mesenchymal stromal cells implantation on the BDNF expression in diabetic foot rats]2013449314[article in Chinese, English Abstract]Search in Google Scholar
You H-J, Namgoong S, Han S-K, Jeong S-H, Dhong E-S, Kim W-K. Wound-healing potential of human umbilical cord blood–derived mesenchymal stromal cells in vitro—a pilot study. Cytotherapy. 2015; 17:1506–13.YouH-JNamgoongSHanS-KJeongS-HDhongE-SKimW-KWound-healing potential of human umbilical cord blood–derived mesenchymal stromal cells in vitro—a pilot study20151715061310.1016/j.jcyt.2015.06.01126212609Search in Google Scholar
Qin H-L, He K-W, Gao B, Ji Y-L, Huang Y-C, Wang S-Q, et al. Human umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation. Chinese J Tissue Eng Res. 2013; 17:2544–51.QinH-LHeK-WGaoBJiY-LHuangY-CWangS-QHuman umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation201317254451Search in Google Scholar
Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002; 13:4279–95.ZukPAZhuMAshjianPDe UgarteDAHuangJIMizunoHHuman adipose tissue is a source of multipotent stem cells20021342799510.1091/mbc.e02-02-010513863312475952Search in Google Scholar
Wu Q, Chen B, Liang Z. Mesenchymal stem cells as a prospective therapy for the diabetic foot. Stem Cells Int. 2016; 2016:4612167. doi: 10.1155/2016/4612167WuQChenBLiangZMesenchymal stem cells as a prospective therapy for the diabetic foot201620164612167.10.1155/2016/4612167510275027867398Open DOISearch in Google Scholar
Nambu M, Ishihara M, Kishimoto S, Yanagibayashi S, Yamamoto N, Azuma R, et al. Stimulatory effect of autologous adipose tissue-derived stromal cells in an atelocollagen matrix on wound healing in diabetic db/db mice. J Tissue Eng. 2011; 2011:158105. doi: 10.4061/2011/158105NambuMIshiharaMKishimotoSYanagibayashiSYamamotoNAzumaRStimulatory effect of autologous adipose tissue-derived stromal cells in an atelocollagen matrix on wound healing in diabetic db/db mice2011201115810510.4061/2011/158105313605921772956Open DOISearch in Google Scholar
Yang M, Sheng L, Zhang TR, Li Q. Stem cell therapy for lower extremity diabetic ulcers: where do we stand? Biomed Res Int. 2013; 2013:462179. doi: 10.1155/2013/462179YangMShengLZhangTRLiQStem cell therapy for lower extremity diabetic ulcers: where do we stand?20132013462179.10.1155/2013/462179361308523586040Open DOISearch in Google Scholar
Hassan WU, Greiser U, Wang W. Role of adipose-derived stem cells in wound healing. Wound Repair Regen. 2014; 22:313–25.HassanWUGreiserUWangWRole of adipose-derived stem cells in wound healing2014223132510.1111/wrr.1217324844331Search in Google Scholar
Kim YJ, Kim HK, Cho HH, Bae YC, Suh KT, Jung JS. Direct comparison of human mesenchymal stem cells derived from adipose tissues and bone marrow in mediating neovascularization in response to vascular ischemia. Cell Physiol Biochem. 2007; 20:867–76.KimYJKimHKChoHHBaeYCSuhKTJungJSDirect comparison of human mesenchymal stem cells derived from adipose tissues and bone marrow in mediating neovascularization in response to vascular ischemia2007208677610.1159/00011044717982269Search in Google Scholar
Ikegame Y, Yamashita K, Hayashi S-I, Mizuno H, Tawada M, You F, et al. Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. Cytotherapy. 2011; 13:675–85.IkegameYYamashitaKHayashiS-IMizunoHTawadaMYouFComparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy2011136758510.3109/14653249.2010.54912221231804Search in Google Scholar
Jiang X-Y, Lu D-B, Chen B. Progress in stem cell therapy for the diabetic foot. Diabetes Res Clin Pract. 2012; 97:43–50.JiangX-YLuD-BChenBProgress in stem cell therapy for the diabetic foot201297435010.1016/j.diabres.2011.12.01122221581Search in Google Scholar
Kim S-W, Zhang H-Z, Guo L, Kim J-M, Kim MH. Amniotic mesenchymal stem cells enhance wound healing in diabetic NOD/SCID mice through high angiogenic and engraftment capabilities. PLoS One. 2012; 7:e41105. doi: 10.1371/journal.pone.0041105KimS-WZhangH-ZGuoLKimJ-MKimMHAmniotic mesenchymal stem cells enhance wound healing in diabetic NOD/SCID mice through high angiogenic and engraftment capabilities20127e4110510.1371/journal.pone.0041105339888922815931Open DOISearch in Google Scholar
Bura A, Planat-Benard V, Bourin P, Silvestre J-S, Gross F, Grolleau J-L, et al. Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia. Cytotherapy. 2014; 16:245–57.BuraAPlanat-BenardVBourinPSilvestreJ-SGrossFGrolleauJ-LPhase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia2014162455710.1016/j.jcyt.2013.11.01124438903Search in Google Scholar
Kato Y, Iwata T, Washio K, Yoshida T, Kuroda H, Morikawa S, et al. Creation and transplantation of an adipose-derived stem cell (ASC) sheet in a diabetic wound-healing model. J Vis Exp. 2017:e54539. doi: 10.3791/54539KatoYIwataTWashioKYoshidaTKurodaHMorikawaSCreation and transplantation of an adipose-derived stem cell (ASC) sheet in a diabetic wound-healing model2017e5453910.3791/54539561401528809824Open DOISearch in Google Scholar
Shingyochi Y, Orbay H, Mizuno H. Adipose-derived stem cells for wound repair and regeneration. Expert Opin Biol Ther. 2015; 15:1285–92.ShingyochiYOrbayHMizunoHAdipose-derived stem cells for wound repair and regeneration20151512859210.1517/14712598.2015.105386726037027Search in Google Scholar
Ito K, Bonora M, Ito K. Metabolism as master of hematopoietic stem cell fate. Int J Hematol. 2019; 109:18–27.ItoKBonoraMItoKMetabolism as master of hematopoietic stem cell fate2019109182710.1007/s12185-018-2534-z631806430219988Search in Google Scholar
Huo Y, Li B-Y, Lin Z-F, Wang W, Jiang X-X, Chen X, et al. MYSM1 is essential for maintaining hematopoietic stem cell (HSC) quiescence and survival. Med Sci Monit. 2018; 24:2541–9.HuoYLiB-YLinZ-FWangWJiangX-XChenXMYSM1 is essential for maintaining hematopoietic stem cell (HSC) quiescence and survival2018242541910.12659/MSM.906876593994829694335Search in Google Scholar
Haspel RL, Miller KB. Hematopoietic stem cells: source matters. Curr Stem Cell Res Ther. 2008; 3:229–36.HaspelRLMillerKBHematopoietic stem cells: source matters200832293610.2174/15748880878673403319075753Search in Google Scholar
Seita J, Weissman IL. Hematopoietic stem cell: self-renewal versus differentiation. Wiley Interdiscip Rev Syst Biol Med. 2010; 2:640–53.SeitaJWeissmanILHematopoietic stem cell: self-renewal versus differentiation201026405310.1002/wsbm.86295032320890962Search in Google Scholar
Hossle JP, Seger RA, Steinhoff D. Gene therapy of hematopoietic stem cells: strategies for improvement. News Physiol Sci. 2002; 17:87–92.HossleJPSegerRASteinhoffDGene therapy of hematopoietic stem cells: strategies for improvement2002178792Search in Google Scholar
Kanji S, Das M, Aggarwal R, Lu J, Joseph M, Pompili VJ, Das H. Nanofiber-expanded human umbilical cord blood–derived CD 34+ cell therapy accelerates cutaneous wound closure in NOD/SCID mice. J Cell Mol Med. 2014; 18:685–97.KanjiSDasMAggarwalRLuJJosephMPompiliVJDasHNanofiber-expanded human umbilical cord blood–derived CD 34+ cell therapy accelerates cutaneous wound closure in NOD/SCID mice2014186859710.1111/jcmm.12217398193924455991Search in Google Scholar
Körbling M, Katz RL, Khanna A, Ruifrok AC, Rondon G, Albitar M, et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med. 2002; 346:738–46.KörblingMKatzRLKhannaARuifrokACRondonGAlbitarMHepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells20023467384610.1056/NEJMoa346100211882729Search in Google Scholar
Kirby GTS, Mills SJ, Cowin AJ, Smith LE. Stem cells for cutaneous wound healing. Biomed Res Int. 2015; 2015:285869. doi: 10.1155/2015/285869KirbyGTSMillsSJCowinAJSmithLEStem cells for cutaneous wound healing2015201528586910.1155/2015/285869446827626137471Open DOISearch in Google Scholar
Sietsema WK, Kawamoto A, Takagi H, Losordo DW. Autologous CD34+ cell therapy for ischemic tissue repair. Circ J. 2019; 83:1422–30.SietsemaWKKawamotoATakagiHLosordoDWAutologous CD34+ cell therapy for ischemic tissue repair20198314223010.1253/circj.CJ-19-024031178469Search in Google Scholar
Barcelos LS, Duplaa C, Kränkel N, Graiani G, Invernici G, Katare R, et al. Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circ Res. 2009; 104:1095–102.BarcelosLSDuplaaCKränkelNGraianiGInverniciGKatareRHuman CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling2009104109510210.1161/CIRCRESAHA.108.192138282101419342601Search in Google Scholar
Chotinantakul K, Dechsukhum C, Dejjuy D, Leeanansaksiri W. Enhancement of wound closure in diabetic mice by ex vivo expanded cord blood CD34+ cells. Cell Mol Biol Lett. 2013; 18:263–83.ChotinantakulKDechsukhumCDejjuyDLeeanansaksiriWEnhancement of wound closure in diabetic mice by ex vivo expanded cord blood CD34+ cells2013182638310.2478/s11658-013-0089-9627598223666595Search in Google Scholar
Lewis P, Silajdžić E, Brison DR, Kimber SJ. Embryonic stem cells. In: Gimble JM, Marolt Preson D, Oreffo R, Wolbank S, Redl H, editors. Cell engineering and regeneration. Redl H, series editor. Reference Series in Biomedical Engineering. Cham: Springer Nature Switzerland; 2020, p. 315–65.LewisPSilajdžićEBrisonDRKimberSJEmbryonic stem cellsIn:GimbleJMMarolt PresonDOreffoRWolbankSRedlHeditors.RedlHseries editor.ChamSpringer Nature Switzerland20203156510.1007/978-3-319-08831-0_19Search in Google Scholar
Lee KB, Choi J, Cho S-B, Chung J-Y, Moon E-S, Kim N-S, Han H-J. Topical embryonic stem cells enhance wound healing in diabetic rats. J Orthop Res. 2011; 29:1554–62.LeeKBChoiJChoS-BChungJ-YMoonE-SKimN-SHanH-JTopical embryonic stem cells enhance wound healing in diabetic rats20112915546210.1002/jor.2138521469178Search in Google Scholar
Loretelli C, Nasr MB, Giatsidis G, Bassi R, Lancerotto L, D’Addio F, et al. Embryonic stem cell extracts improve wound healing in diabetic mice. Acta Diabetol. 2020: 57:883–90.LoretelliCNasrMBGiatsidisGBassiRLancerottoLD’AddioFEmbryonic stem cell extracts improve wound healing in diabetic mice2020578839010.1007/s00592-020-01500-032124076Search in Google Scholar
Lee MJ, Kim J, Lee KI, Shin JM, Chae JI, Chung HM. Enhancement of wound healing by secretory factors of endothelial precursor cells derived from human embryonic stem cells. Cytotherapy. 2011; 13:165–78.LeeMJKimJLeeKIShinJMChaeJIChungHMEnhancement of wound healing by secretory factors of endothelial precursor cells derived from human embryonic stem cells2011131657810.3109/14653249.2010.51263221235296Search in Google Scholar
Clark RAF, Lanigan JM, DellaPelle P, Manseau E, Dvorak HF, Colvin RB. Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization. J Invest Dermatol. 1982; 79:264–9.ClarkRAFLaniganJMDellaPellePManseauEDvorakHFColvinRBFibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization198279264910.1111/1523-1747.ep125000756752288Search in Google Scholar
Mohib K, Allan D, Wang L. Human embryonic stem cell-extracts inhibit the differentiation and function of monocyte-derived dendritic cells. Stem Cell Rev Rep. 2010; 6:611–21.MohibKAllanDWangLHuman embryonic stem cell-extracts inhibit the differentiation and function of monocyte-derived dendritic cells201066112110.1007/s12015-010-9185-720711689Search in Google Scholar
Gorecka J, Kostiuk V, Fereydooni A, Gonzalez L, Luo J, Dash B, et al. The potential and limitations of induced pluripotent stem cells to achieve wound healing. Stem Cell Res Ther. 2019; 10:87. doi: 10.1186/s13287-019-1185-1GoreckaJKostiukVFereydooniAGonzalezLLuoJDashBThe potential and limitations of induced pluripotent stem cells to achieve wound healing2019108710.1186/s13287-019-1185-1641697330867069Open DOISearch in Google Scholar
Bian X, Ma K, Zhang C, Fu X. Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases. Stem Cell Res Ther. 2019; 10:158. doi: 10.1186/s13287-019-1276-zBianXMaKZhangCFuXTherapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases20191015810.1186/s13287-019-1276-z654572131159859Open DOISearch in Google Scholar
Yoshida Y, Yamanaka S. Recent stem cell advances: induced pluripotent stem cells for disease modeling and stem cell–based regeneration. Circulation. 2010; 122:80–7.YoshidaYYamanakaSRecent stem cell advances: induced pluripotent stem cells for disease modeling and stem cell–based regeneration201012280710.1161/CIRCULATIONAHA.109.88143320606130Search in Google Scholar
Singh VK, Kalsan M, Kumar N, Saini A, Chandra R. Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery. Front Cell Dev Biol. 2015; 3:2. doi: 10.3389/fcell.2015.00002SinghVKKalsanMKumarNSainiAChandraRInduced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery20153210.3389/fcell.2015.00002431377925699255Open DOISearch in Google Scholar
Baraniak PR, McDevitt TC. Stem cell paracrine actions and tissue regeneration. Regen Med. 2010; 5:121–43.BaraniakPRMcDevittTCStem cell paracrine actions and tissue regeneration201051214310.2217/rme.09.74283327320017699Search in Google Scholar
Clayton ZE, Tan RP, Miravet MM, Lennartsson K, Cooke JP, Bursill CA, et al. Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model. Biosci Rep. 2018; 38:BSR20180563. doi: 10.1042/BSR20180563ClaytonZETanRPMiravetMMLennartssonKCookeJPBursillCAInduced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model201838BSR20180563.10.1042/BSR20180563606665729976773Open DOISearch in Google Scholar
Itoh M, Umegaki-Arao N, Guo Z, Liu L, Higgins CA, Christiano AM. Generation of 3D skin equivalents fully reconstituted from human induced pluripotent stem cells (iPSCs). PLoS One. 2013; 8:e77673. doi: 10.1371/journal.pone.0077673ItohMUmegaki-AraoNGuoZLiuLHigginsCAChristianoAMGeneration of 3D skin equivalents fully reconstituted from human induced pluripotent stem cells (iPSCs)20138e7767310.1371/journal.pone.0077673379568224147053Open DOISearch in Google Scholar
Gerami-Naini B, Smith A, Maione AG, Kashpur O, Carpinito G, Veves A, et al. Generation of induced pluripotent stem cells from diabetic foot ulcer fibroblasts using a nonintegrative Sendai virus. Cell Reprogram. 2016; 18:214–23.Gerami-NainiBSmithAMaioneAGKashpurOCarpinitoGVevesAGeneration of induced pluripotent stem cells from diabetic foot ulcer fibroblasts using a nonintegrative Sendai virus2016182142310.1089/cell.2015.0087496476027328415Search in Google Scholar
Zheng Y, Ji S, Wu H, Tian S, Zhang Y, Wang L, et al. Topical administration of cryopreserved living micronized amnion accelerates wound healing in diabetic mice by modulating local microenvironment. Biomaterials. 2017; 113:56–67.ZhengYJiSWuHTianSZhangYWangLTopical administration of cryopreserved living micronized amnion accelerates wound healing in diabetic mice by modulating local microenvironment2017113566710.1016/j.biomaterials.2016.10.03127810642Search in Google Scholar
Lv Y, Ge L, Zhao Y. Effect and mechanism of SHED on ulcer wound healing in Sprague-Dawley rat models with diabetic ulcer. Am J Transl Res. 2017; 9:489–98.LvYGeLZhaoYEffect and mechanism of SHED on ulcer wound healing in Sprague-Dawley rat models with diabetic ulcer2017948998Search in Google Scholar
Badillo AT, Redden RA, Zhang L, Doolin EJ, Liechty KW. Treatment of diabetic wounds with fetal murine mesenchymal stromal cells enhances wound closure. Cell Tissue Res. 2007; 329:301–11.BadilloATReddenRAZhangLDoolinEJLiechtyKWTreatment of diabetic wounds with fetal murine mesenchymal stromal cells enhances wound closure20073293011110.1007/s00441-007-0417-317453245Search in Google Scholar
da Silva LP, Santos TC, Rodrigues DB, Pirraco RP, Cerqueira MT, Reis RL, et al. Stem cell-containing hyaluronic acid-based spongy hydrogels for integrated diabetic wound healing. J Invest Dermatol. 2017; 137:1541–51.da SilvaLPSantosTCRodriguesDBPirracoRPCerqueiraMTReisRLStem cell-containing hyaluronic acid-based spongy hydrogels for integrated diabetic wound healing201713715415110.1016/j.jid.2017.02.97628259681Search in Google Scholar
Kwon DS, Gao X, Liu YB, Dulchavsky DS, Danyluk AL, Bansal M, et al. Treatment with bone marrow-derived stromal cells accelerates wound healing in diabetic rats. Int Wound J. 2008; 5:453–63.KwonDSGaoXLiuYBDulchavskyDSDanylukALBansalMTreatment with bone marrow-derived stromal cells accelerates wound healing in diabetic rats200854536310.1111/j.1742-481X.2007.00408.x385290718593394Search in Google Scholar
Ho JH, Tseng T-C, Ma W-H, Ong W-K, Chen Y-F, Chen M-H, et al. Multiple intravenous transplantations of mesenchymal stem cells effectively restore long-term blood glucose homeostasis by hepatic engraftment and β-cell differentiation in streptozocin-induced diabetic mice. Cell Transplant. 2012; 21:997–1009.HoJHTsengT-CMaW-HOngW-KChenY-FChenM-HMultiple intravenous transplantations of mesenchymal stem cells effectively restore long-term blood glucose homeostasis by hepatic engraftment and β-cell differentiation in streptozocin-induced diabetic mice201221997100910.3727/096368911X60361122004871Search in Google Scholar
Acosta L, Hmadcha A, Escacena N, Pérez-Camacho I, de la Cuesta A, Ruiz-Salmeron R, et al. Adipose mesenchymal stromal cells isolated from type 2 diabetic patients display reduced fibrinolytic activity. Diabetes. 2013: 62:4266–9.AcostaLHmadchaAEscacenaNPérez-CamachoIde la CuestaARuiz-SalmeronRAdipose mesenchymal stromal cells isolated from type 2 diabetic patients display reduced fibrinolytic activity2013624266910.2337/db13-0896383706124043757Search in Google Scholar
Wang Y, Han Z-B, Song Y-P, Han ZC. Safety of mesenchymal stem cells for clinical application. Stem Cells Int. 2012; 2012:652034. doi: 10.1155/2012/652034WangYHanZ-BSongY-PHanZCSafety of mesenchymal stem cells for clinical application2012201265203410.1155/2012/652034336328222685475Open DOISearch in Google Scholar
Rubio D, Garcia-Castro J, Martín MC, de la Fuente R, Cigudosa JC, Lloyd AC, et al. Spontaneous human adult stem cell transformation. Cancer Res. 2005; 65:3035–9.RubioDGarcia-CastroJMartínMCde la FuenteRCigudosaJCLloydACSpontaneous human adult stem cell transformation2005653035910.1158/0008-5472.CAN-04-419415833829Search in Google Scholar
de la Fuente R, Bernad A, Garcia-Castro J, Martín MC, Cigudosa JC. Retraction: Spontaneous human adult stem cell transformation. Cancer Res. 2010; 70:6682.de la FuenteRBernadAGarcia-CastroJMartínMCCigudosaJCRetraction: Spontaneous human adult stem cell transformation201070668210.1158/0008-5472.CAN-10-245120710046Search in Google Scholar
Yang S-S, Kim N-R, Park K-B, Do Y-S, Roh K, Kang K-S, et al. A phase I study of human cord blood-derived mesenchymal stem cell therapy in patients with peripheral arterial occlusive disease. Int. J Stem Cells. 2013; 6:37–44.YangS-SKimN-RParkK-BDoY-SRohKKangK-SA phase I study of human cord blood-derived mesenchymal stem cell therapy in patients with peripheral arterial occlusive disease20136374410.15283/ijsc.2013.6.1.37384100224298372Search in Google Scholar
Qi L, Ahmadi AR, Huang J, Chen M, Pan B, Kuwabara H, et al. Major improvement in wound healing through pharmacologic mobilization of stem cells in severely diabetic rats. Diabetes. 2020; 69:699–712.QiLAhmadiARHuangJChenMPanBKuwabaraHMajor improvement in wound healing through pharmacologic mobilization of stem cells in severely diabetic rats20206969971210.2337/db19-090731974141Search in Google Scholar