Recommendations of the Polish Society of Epileptology for the treatment of epileptic seizure in adult patients in Poland: an update
, , , e | 27 mar 2019
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Article Category: research-article
Pubblicato online: 27 mar 2019
Pagine: 9 - 16
Ricevuto: 13 mar 2019
Accettato: 14 mar 2019
DOI: https://doi.org/10.21307/joepi-2019-002
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© 2019 Joanna Jędrzejczak et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Recommendation for the choice of AEDs in monotherapy and add-on treatment in adults with epilepsy according to seizure type
| Type of seizure | Monotherapy/Alternative monotherapy I – Line Drugs | Add-on therapy II – Line Drugs | Add-on therapy III – Line Drugs |
|---|---|---|---|
| Focal (Focal onset) | CBZ, GBP, LEV, LTG, OXC, VPA | CBZ, GBP, LCM, LEV, LTG, PGB, OXC, TPM, VPA | BRI, ESL, PB, PHT, PER, RFN, TGB, VGB, ZNS |
| Primary generalized tonicclonic (Generalized onset motor tonic-clonic) | LEV, LTG, VPA | CLB, LEV, LTG, TPM, VPA | |
| Myoclonic (Generalized onset motor myoclonic) | VPA | LEV, LTG, TPM, VPA | CLB, CLN, ZNS, piracetam (In Dravet Syndrome to consider: CBD and STR) |
| Generalized atonic/tonic (Generalized onset motor atonic/tonic) | VPA | LTG To consider: TPM | RFN (In Lennox-Gastaut Syndrome to consider: CBD) |
| Absence (Generalized onset non-motor) | ESM, VPA | ESM, LTG, TPM, VPA | CLB, CLN, LEV, ZNS |
The new International League Against Epilepsy 2017 operational classification of seizure types (basic version) (Fisher et al., 2017a)
| FOCAL ONSET | GENERALIZED ONSET | UNKNOWN ONSET | |
|---|---|---|---|
| Aware | Impaired awareness | Impaired awareness | |
| Tonic-clonic other motor | Tonic-clonic other motor | ||
| Focal to bilateral tonic-clonic | Unclassified | ||