<abstract xmlns="http://www.w3.org/1999/xhtml">

A patient with end-stage renal disease on chronic dialysis was admitted to the hospital for renal transplantation evaluation. Blood type and antibody detection tests were performed. The antibody detection test results were positive. Initial antibody identification studies indicated the presence of a panagglutinin. The patient’s autocontrol was negative. The antibody was subsequently identified by a reference laboratory as anti-Ata (Augustine), which is an extremely rare antibody due to the high prevalence of Ata in the general population. A monocyte monolayer assay (MMA) was performed to assess the clinical significance of the antibody in the event that blood was needed for transfusion, and At(a–) RBCs were not available. The MMA results predicted the antibody to be capable of causing hemolysis <italic>in vivo</italic>. A brief historical review of the incidence and clinical significance of this antibody is included in this case report.
</abstract>

A patient with end-stage renal disease on chronic dialysis was admitted to the hospital for renal transplantation evaluation. Blood type and antibody detection tests were performed. The antibody detection test results were positive. Initial antibody identification studies indicated the presence of a panagglutinin. The patient’s autocontrol was negative. The antibody was subsequently identified by a reference laboratory as anti-Ata (Augustine), which is an extremely rare antibody due to the high prevalence of Ata in the general population. A monocyte monolayer assay (MMA) was performed to assess the clinical significance of the antibody in the event that blood was needed for transfusion, and At(a–) RBCs were not available. The MMA results predicted the antibody to be capable of causing hemolysis in vivo. A brief historical review of the incidence and clinical significance of this antibody is included in this case report.

Anti-Ata in a renal transplant candidate: a case report

Immunohematology

Anti-At in a renal transplant candidate: a case report

{"article-title":{"content":["Anti-At","in a renal transplant candidate: a case report"],"sup":"a"}}

A patient with end-stage renal disease on chronic dialysis was admitted to the hospital for renal transplantation evaluation. Blood type and antibody detection...

Anti-At^a in a renal transplant candidate: a case report

Article Category: article

Pubblicato online: 01 gen 2020

Pagine: 104 - 107

DOI: https://doi.org/10.21307/immunohematology-2020-049

Parole chiave
Augustine blood group system, renal transplantation, monocyte monolayer assay (MMA), polyethylene glycol (PEG), At

© 2020 J. Gao et al., published by Sciendo